review

Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates

Andrea L. Suárez, Jamison D. Feramisco, John Koo , Martin Steinhoff

Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course defined by symptomatic flares and remissions. The mechanisms of disease exacerbation are still poorly understood. Clinical occurrence of atopic dermatitis is often associated with psychological stress. In response to stre ...

investigative

IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis

Stephan Nobbe, Piotr Dziunycz , Beda Mühleisen , Janine Bilsborough, Stacey R. Dillon, Lars E. French, Günther F.L. Hofbauer

Interleukin-31 (IL-31) is a recently discovered cytokine expressed in many human tissues, and predominantly by activated CD4+ T cells. IL-31 signals through a heterodimeric receptor consisting of IL-31 receptor alpha (IL-31RA) and oncostatin M receptor beta (OSMR). Earlier studies have shown involvement of IL-31 and its receptor components IL-31RA and OSMR in atopic dermatitis, pruritus and Th2-we ...

editorial

New Section Editors, One-Year Experience of Open Access and Now Also Apps for iPad and iPhone

Anders Vahlquist and Agneta Andersson

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