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Acta Dermato-Venereologica
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The Potential Role of Impaired Notch Signalling in Atopic DermatitisReview
The Potential Role of Impaired Notch Signalling in Atopic Dermatitis
Bodo C. Melnik

This review presents recent evidence of impaired Notch signalling in atopic dermatitis (AD), which is proposed to represent the “a-topic” defect linking both epidermal and immunological barrier dysfunctions in AD. AD epidermis exhibits a marked deficiency of Notch receptors. Mouse models with genetically suppressed Notch signalling exhibit dry skin, signs of scratching, skin barrier abnormalitie ...


Gender Differences in Itch and Pain-related Sensations Provoked by Histamine, Cowhage and CapsaicinInvestigative Report
Gender Differences in Itch and Pain-related Sensations Provoked by Histamine, Cowhage and Capsaicin
Elisabeth M. Hartmann, Herman O. Handwerker, Clemens Forster

Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects. Sensory qualities were assessed by questionnaire; intensities and time courses of the “itching” and “burning” sensation were measured alternately, but continuously on a VAS. In addition, axon reflexes were assessed. Only histamine and capsaicin pro ...


Cutaneous Leishmaniasis in Syria: Clinical Features, Current Status and the Effects of WarClinical Report
Cutaneous Leishmaniasis in Syria: Clinical Features, Current Status and the Effects of War
Kinan Hayani, Anwar Dandashli, Elke Weisshaar

Cutaneous leishmaniasis (CL) is a worldwide disease caused by an infection with the protozoan parasite Leishmania transmitted via sand flies. It is endemic in many of the poorest countries of all continents. “Aleppo boil” is one of the recognised names given to this disease in the medical literature. Although CL used to be well-controlled and well-documented in Syria, its incidence has dramatica ...


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New release of full articles

Short communication - 2014-12-11
Localised Dominant Dystrophic Epidermolysis Bullosa with a Novel de Novo Mutation in COL7A1 Diagnosed by Next-generation Sequencing
Makoto Nagai, Hiroshi Nagai, Chiharu Tominaga, Yoshiko Sakaguchi, Orie Jitsukawa, Noriko Ohgo, Chikako Nishigori, Kiyofumi Yamanishi

Quiz - 2014-12-05
A Painful Nodule On The Leg: A Quiz
Fernando Cammisuli, Vito Catania, Maria Rita Nasca, Andrea Failla, Giuseppe Micali

Short communication - 2014-12-03
Disseminated Primary Cutaneous CD8+ Small/Medium-sized Pleomorphic T-cell Lymphoma Responding to Hydroxychloroquine
Valerie C. Amann, Jil Dreier, Desislava Ignatova, Jivko Kamarashev, Katrin Kerl, Werner Kempf, Steve Pascolo, Reinhard Dummer, Antonio Cozzio, Emmanuella Guenova

Short communication - 2014-12-03
A Male with Group B Streptococcal Necrotizing Fasciitis at Multiple Sites Secondary to Multifocal Septic Arthritis
Hiroshi Umemura, Keita Hiragushi, Susumu Sasaki, Hiroko Doi, Naofumi Shiota, Koji Kabutan, Kenji Asagoe

Clinical Report - 2014-12-02
Incidence, Serum IgE and TARC/CCL17 Levels in Atopic Dermatitis Associated with Other Allergic Diseases: An Update from the Ishigaki Cohort
Satoshi Takeuchi, Hitokazu Esaki, Norihiro Furusyo, Sayaka Hayashida, Kazuhiko Yamamura, Gaku Tsuji, Masaki Takemura, Jun Hayashi, Masutaka Furue

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ISI Impact Factor 2013: 4.244

No. 5 among the world's dermatological journals – highest in Europe!

An international peer-reviewed journal for clinical and experimental research in the field of dermatology and venereology.

Published by a Non-Profit Organization

Topics: Atopic dermatitis and contact allergy, facial dermatoses and adnexal disorders, new treatments, psoriasis and genodermatoses, psychodermatology, sexually transmitted diseases, skin biology and inflammation, skin cancer and pigmentation, skin immunology and lymphoma, urticaria and itch, wound healing and tissue repair


The official Journal of:
International Forum for the Study of Itch
European Society for Dermatology and Psychiatry

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