Content - Volume 74, Issue 3

The immunohistochemical localization of p53 protein was examined in skin tissue sections, including normal vascular endothelial cells and the skin tissue sections from lesions of granuloma telangiectaticum with proliferation of vascular endothelial cells and malignant hemangioendothelioma, a malignant tumor originated from vascular endothelial cells. It was found that p53 protein was positive in 2 ...

Proliferation of mast cells can give rise to many clinical manifestations in patients, and an association with hematological disorders has been pointed out. The study was initiated to determine whether patients with mastocytosis show a clinical progression in relation to bone marrow cell parameters analyzed. During a median follow-up period of 5.5 years, 10 patients with mastocytosis were re-exami ...

The aim of this study was to standardize the recording technique of the SERVO MED Ep 1C to determine the rest time required for human subjects to obtain stabilized values of transepidermal water loss (TEWL). Measurements of TEWL were performed on the flexor side of the forearm in healthy volunteers. First, different sites were tested on different days to study intra- and inter-individual variation ...

Patients with nickel allergy and different types of eczema with and without atopy were given a single oral dose of nickel sulfate. Blood levels and urinary excretion were determined by atomic absorption spectrophotometry. Urinary excretion of nickel was found to be dependent on age, decreasing with increasing age. When difference in age between the eczema groups was taken into account, the level o ...

The disaccharide contents of chondroitinase-digestible glycosaminoglycans extracted from a 6-mm punch biopsy of the forearm skin were determined using high-performance liquid chromatography after 1-phenyl-3-methyl-5-pyrasolone labelling. In 9 patients with systemic sclerosis, the amounts of both the main disaccharide unit of dermatan sulfate and chondroitin sulfate C increased significantly, as co ...

The epidermal Langerhans' cells are dendritic cells of the skin capable of triggering cutaneous immune responses. They possess the membrane antigens required to this effect: class II histocompatibility antigen, CD1a and CD4; the latter acts as receptor for the human immunodeficiency virus. The skin is the organ primarily affected by Kaposi's sarcoma (KS). In epidemic KS, the local immunologic cond ...

In tall animals dependent tissues are stiffer to prevent oedema formation in the upright posture, but whether the same adaptation is operating in man is not known. Skin elasticity and distensibility were measured in vivo in 18 young and 15 aged individuals in the morning before getting up (baseline) and 12 h later. In young individuals skin was stiffer (less distensible) and less elastic in the ac ...

Normal microcirculation of the lower extremity is characterized by the venoarteriolar vasoconstriction reflex and the disappearance of vasomotion in the dependent position. Patients with sickle cell disease are prone to develop ischemic leg ulcers at an early age. Dysfunction of the microcirculation might promote the development of leg ulcers in patients with sickle cell disease. Using laser Doppl ...

The venoarteriolar vasoconstriction reflex plays a major role in the prevention of leg oedema in the upright position in man. We studied the venoarteriolar vasoconstriction reflex with laser Doppler flowmetry in young (21 subjects, age 17-27) and very old (20 subjects, age 75-100) healthy volunteers. In the group of young volunteers, after lowering of the lower extremity 50 cm below the heart leve ...

There is no single immunoelectron microscopical method for invariably effective localization of both intracellular and extracellular antigens. We describe a simple and practicable immunogold technique that can be used to localize various skin basement membrane zone antigens at the ultrastructural level. Small pieces of skin were incubated with primary antibodies recognizing epitopes on a range of ...

Photodynamic therapy consists of the combination of photosensitizers absorbing light in the visible spectral region and irradiation with light of corresponding wavelengths. We analysed its effects in comparison to PUVA treatment on cell lines MyLA and HuT78, established from patients with cutaneous T cell lymphomas. Proliferation was reduced to 50% by exposure to 7.5 J/cm2 UV-A (= ED50). This effe ...

he authors report a 39-year-old man who developed a phalangeal osteomyelitis of the right thumb in consequence of nail biting. Cultures grew Staphylococcus aureus. Treatment with intravenous teicoplamine 400 mg/day for 3 weeks resulted in complete cure of infection.

We report a patient with an inflammatory linear verrucous epidermal naevus (ILVEN) coexisting with an auto-immune lymphocytic thyroiditis. The occurrence of two epithelial inflammatory processes could be linked and raises the question of auto-immune involvement in the inflammatory part of ILVEN. Moreover, expression of a membrane antigen, OKM5, usually assigned to antigen-presenting cells, especia ...

The copper vapour laser has in theory qualities which make it interesting in the treatment of cutaneous vascular malformations. In order to study the clinical effect of the copper vapour laser and to compare its effect with the effect of the argon laser, we treated 38 patients with port-wine stain or facial telangiectasia with the copper vapour laser. Thirty-one patients were evaluated and of thes ...

Heat therapy of cutaneous diseases has been used for decades. During the last years several kinds of energy sources, including electromagnetic energy from radiofrequency, microwaves and sonic energy from ultrasound, have been used to produce local hyperthermia. The general principle of this treatment is based on the fact that disease tissue which is being treated is more sensitive to the effects o ...

A 55-year-old teacher had had painful subcutaneous swellings on both her arms for 6 years, after receiving intramuscular multivitamin injections for generalized weakness. She did not have fever, constitutional or systemic symptoms. Cutaneous examination revealed ill-defined, subcutaneous, firm, globular, indurated, tender swellings with central softening on both the arms. There was no systemic inv ...

Pachydermodactyly is a rare and benign form of digital fibromatosis with only a few cases described in the literature. We report two cases of pachydermodactyly affecting young men. In one of them a knuckle pad was found, and the fibromatous thickening of the skin affected not only the finger joints but also the dorsum of the hands. This case can be included in the particular clinical form named pa ...

We report a case of acquired immunodeficiency syndrome with pruritic papular eruption. The patient, a hemophiliac, presented with generalized pruritic, skin-colored papules and nodules. The chronic lesions were excoriated and hyper-pigmented. The eosinophil count was elevated, but IgE was normal. The lesions and pruritus responded only to ultraviolet B phototherapy. While the mechanism is not know ...

Generalized normolipemic plane xanthomatosis is a rare cutaneous disorder, frequently associated with reticuloendothelial diseases and some disorders with inflammation. Relapsing polychondritis is also a rare disease that shows an association with various immune-mediated diseases. We report a case of generalized normolipemic plane xanthomatosis associated with relapsing polychondritis in a 56-year ...

A case of recurrent generalized lichen nitidus is reported. The eruptions developed in the proliferative phase of the menstrual cycle, but there has been a marked improvement after administration of estrogen and progesterone for the treatment of amenorrhea. Hormonal factors may play a role in the development of lichenoid tissue reaction in the lesions of this disease.

We have developed a technique through which we can multiply melanocytes in culture from a small specimen of normally pigmented buttock skin and reimplant them into depigmented sites of vitiligo. To date, 90 patients have benefited in our hands from such autologous transplantation of pigment cells. Often we have an excess of cells which we would like to store for later use in the event a patient re ...

Comment on Cutaneous paraneoplastic syndromes. [Acta Derm Venereol. 1993]

Comment on Multiple milia during treatment with acitretin for mycosis fungoides. [Acta Derm Venereol. 1993]