Content - Volume 78, Issue

After years of therapeutic triviality, we now have drugs with a major effect on onychomycosis, and, paradoxically, their very success will lead to the development of more such drugs. This note is concerned with improving their assessment by rationalising the way in which efficacy is measured. The need for this will be apparent to anyone who has had to review studies of antifungal drugs for onycho ...

Cutaneous microdialysis is a method of measuring endogenous and exogenous compounds in the dermal interstitial fluid. The microdialysis probe is inserted in the dermis using a guide cannula. The insertion trauma was studied in dorsal forearm skin in a total of 28 human healthy volunteers. Twenty-four volunteers received local anaesthesia (Xylocain® 10 mg/ml) in both fore-arms and a microdialysis ...

Microdialysis is a method by which compounds can be studied in the extracellular space in skin, in vivo . The microdialysis probe is inserted in the dermis using a guide cannula. It is expected that intradermal oedema associated with insertion trauma as well as the probe depth can influence the results of microdialysis studies. The aim of the present study was to assess the effects of insertion ...

Corticosteroids are one of the most frequently prescribed local therapeutic treatments. Their potency and bioavailability are tested with different methods. One of the most accepted methods is the skin-blanching test designed by McKenzie. In this study we investigated whether the skin-blanching test designed by McKenzie for screening topically active corticosteroids, producing vasoconstriction, i ...

Endoglin is a glycoprotein which is predominantly expressed on endothelial cells. It is upregulated under inflammatory conditions as well as in skin lesions where endothelial cell proliferation occurs. Endoglin has the capacity to bind transforming growth factor beta (TGF-β) and can reduce the bioavailability of TGF-β. TGF-β has a growth-inhibiting effect on keratinocytes and a restraining inf ...

Endothelins (ETs), in addition to their systemical activities, exert important functions at the skin level, such as increase of keratinocyte proliferation, neo-angiogenesis and leukocyte chemotaxis, which are among the main characteristics of psoriasis. To assess a possible ET-1 involvement in plaque-type psoriasis, ET-1 determinations were carried out in 15 sera and 8 lesional and non-lesional b ...

Atopic dermatitis skin tends to be easily irritated and appears dry. These clinical peculiarities correspond to impaired barrier function and to increased transepidermal water loss (TEWL) values. A few studies suggest that a reduced amount of total ceramides (especially of ceramide 1) is responsible for functional abnormalities of the skin of atopic dermatitis patients. The aim of this study was ...

5-S-Cysteinyldopa (5SCD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) are formed during biosynthesis of melanins. They are used as indicators of pigment formation and markers of melanoma progression in adults and could possibly be used as markers of activity, growth and even malignant transformation in large pigmented naevi in children. We investigated the urinary excretion of these ...

Whether the impact of skin biological age on cytokine expression is a result of this tissue's proliferation potential or not is an important issue in dermatology. We investigated these questions by monitoring cytokine marker mRNA expression from human skin samples from healthy groups of individuals. The skin samples studied represented three age groups: fetal (17-21 weeks), young (18-35 years) an ...

Cyclosporine is efficacious in short-term treatment of various eczematous disorders. In a follow-up study we have evaluated the long-term efficacy of cyclosporine in 75 patients, who in previous studies had been treated with cyclosporine for chronic actinic dermatitis (6 patients), atopic dermatitis (42 patients) and chronic hand eczema (27 patients), 4, 2 and 1 year after the initial treatment, ...

Thirty patients without obvious skin disease but with subjective skin symptoms related to work with visual display units (VDUs) and 32 healthy persons were single-blind-tested with a solution of 5% lactic acid and pure water on their cheeks. Thirteen of the patients and 6 control persons reacted positively as "stingers" (p 0.05) in this objective test of sensitive skin. The reason why some patien ...

Early treatment of recrudescent herpes labialis over the symptomatic area has been claimed to inhibit the clinical signs of recrudescent herpes labialis. Electronic infrared thermography can both recognise the prodromal phase and identify the area requiring drug therapy. Our objective was to use infrared thermography to identify prodromal herpes and follow the response to topical acyclovir cream ...

The free-running ruby laser has recently been introduced for removal of unwanted hair growth. It is assumed that the mode of action of ruby laser depilation is that of selective photothermolysis of the melanin-rich structures. The present data reflects our results of ruby treatment of 133 patients attending a dermatological laser clinic for hair removal. When success of the laser treatment was de ...

The presence of 9 common preservatives was investigated in 100 moisturizers by high-performance liquid chromatography. According to the manufacturers/suppliers 88 of the 100 moisturizers contained at least one of the 9 preservatives. This information was erroneous in 9 cases (10.2%). When the moisturizers were investigated for the presence of the 9 preservatives which should not be present in the ...

Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility that some cases of Rowell's syndrome may be manifestations of subacute lupus eryt ...

Detergent enzymes may cause skin irritation and occasionally hypersensitivity reactions. The potential hazards of these enzymes have led some physicians to advise atopic dermatitis patients against the use of enzyme-enriched detergents. A three-phased randomised, double-blind, cross-over experiment was designed to question this recommendation. Each period was of 1 month's duration. In the first p ...

Urine samples from 467 men living in the Stockholm area were tested with the polymerase chain reaction (PCR), Roche Amplicor, and with an enzyme-linked immunosorbent assay, Syva MicroTrak EIA, for detection of Chlamydia trachomatis . The predictive value of urine versus urethral samples was subsequently compared on a second urethral sample from 25 C. trachomatis -positive cases. The urethral sa ...

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