Content

Content - Volume 99, Issue 1

Editor's choice in this issue

INVESTIGATIVE REPORT
Mortality in Patients with Bullous Pemphigoid: A Retrospective Cohort Study, Systematic Review and Meta-analysis
Khalaf Kridin, Wesal Shihade, Reuven Bergman
- A 3.4-fold excess mortality and 27% 1-year mortality rate were recognized among Israeli patients with BP.
- The pooled estimate for 1-year mortality in BP patients is 23.5% worldwide.
- The pooled estimate for 1-year mortality is significantly higher in European cohorts relative to American and Asian ones.

Figure legend: Survival among all patients diagnosed with BP throughout 2000-2015 compared with expected survival.
Pages: 72-77
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CLINICAL REPORT
Rosacea and Demodicosis: Little-known Diagnostic Signs and Symptoms
Fabienne M.N. Forton, Viviane De Maertelaer
Papulopustular rosacea and demodicosis are common facial skin conditions that can be difficult to diagnose clinically. In addition to well-known signs, such as vascular signs, papules and ocular involvement, we show that other signs and symptoms (discreet facial follicular scales, dandruff, folliculitis on the scalp, facial or scalp pruritus) are also frequently present. Their detection should encourage dermatologists to perform a Demodex density test to ensure correct diagnosis.
Pages: 47-52
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All articles

EDITORIAL
Change of Editor-in-Chief
Anders Vahlquist and Agneta Andersson
Abstract is missing (Editorial)
Page: 3
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COMMENTARY
Predatory Journals in Dermatology: A Hidden Danger
Guy Shalom
Abstract is missing (Commentary)
Pages: 4-4
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REVIEW
Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review
Elisabeth B.M. Petersen, Lone Skov, Jacob P. Thyssen, Peter Jensen
The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, ...
Pages: 5-11
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SPECIAL REPORT
Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis
Solam Lee, Young Bin Lee, Sung Jay Choe, Won-Soo Lee
Treatment of male androgenetic alopecia with 5α-reductase inhibitors is efficacious. However, the risk of adverse sexual effects remains controversial. This systematic review and meta-analysis investigated the risk of adverse sexual effects due to treatment of androgenetic alopecia in male patients with finasteride, 1 mg/day, or dutasteride, 0.5 mg/day. Fifteen randomized double-blinded placebo-c ...
Pages: 12-17
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CLINICAL REPORT
Prevalence of Psoriasis and Psoriatic Arthritis and Patient Perceptions of Severity in Sweden, Norway and Denmark: Results from the Nordic Patient Survey of Psoriasis and Psoriatic Arthritis
Kjersti Danielsen, Albert Duvetorp, Lars Iversen, Mikkel Østergaard, Oliver Seifert, Kåre Steinar Tveit, Lone Skov
Optimal clinical management of psoriasis and psoriatic arthritis (PsA) Optimal clinical management of psoriasis and psoriatic arthritis (PsA) requires understanding of the impact on patients. The NORdic PAtient survey of Psoriasis and PsA (NORPAPP) aimed to obtain current data on disease prevalence and patient perceptions in Sweden, Denmark and Norway. Among 22,050 individuals questioned, the repo ...
Pages: 18-25
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CLINICAL REPORT
Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria
Heleen J. de Groot, Marcel F. Jonkman, Hendri H. Pas, Gilles F.H. Diercks
Mechanobullous epidermolysis bullosa acquisita (mEBA) can have a clinical presentation that is very similar to other blistering diseases, such as porphyria cutanea tarda (PCT) and pseudoporphyria. Direct immunofluorescence is an important feature in the diagnosis of mEBA, although features that overlap with PCT and pseudoporphyria have been reported. This retrospective observational study investig ...
Pages: 26-32
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CLINICAL REPORT
Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation
Ignacio Gómez-Martín, Sara Moreno, Xavier Duran, Ramon M. Pujol, Sonia Segura
Pink flat skin lesions on the legs in elderly people represent a diagnostic challenge due to the paucity of clinical and dermoscopic evidence. A prospective study of 114 pink flat lesions on the legs of 85 elderly patients was performed to describe the utility of reflectance confocal microscopy in this clinical context. Evaluation of clinical, dermoscopic and confocal parameters and calculation of ...
Pages: 33-40
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CLINICAL REPORT
Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study
Jung-Won Shin, Chang-Hun Huh, Min-Woo Kim, Ji-Su Lee, Ohsang Kwon, Soyun Cho, Hyun-sun Park
Treatment of alopecia totalis and alopecia universalis is often challenging and unsatisfactory. Recently, Janus kinase inhibitor has shown promising results. The aim of this study is to compare the efficacy and tolerability of oral tofacitinib and conventional modalities for treating refractory alopecia totalis/universalis. A total of 74 patients (18 treated with tofacitinib, 26 treated with conve ...
Pages: 41-46
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CLINICAL REPORT
Rosacea and Demodicosis: Little-known Diagnostic Signs and Symptoms
Fabienne M.N. Forton, Viviane De Maertelaer
Papulopustular rosacea and demodicosis are characterized by non-specific symptoms, which can make clinical diagnosis difficult. This retrospective study of 844 patients assessed the diagnostic importance of clinical signs and symptoms that are poorly recognized as being associated with these conditions. In addition to well-known signs (vascular signs (present in 80% of patients), papules (39%), pu ...
Pages: 47-52
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CLINICAL REPORT
Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial
Ofir Artzi, Eli Sprecher, Amir Koren, Joseph N. Mehrabi, Oren Katz, Yuval Hilerowich
Conventional treatment of cutaneous leishmaniasis often leaves permanent scars with frequent psychosocial sequelae. The aim of this study was to compare the efficacy, safety, associated pain and final cosmetic outcome of fractional carbon dioxide (CO2) laser followed by topical application of sodium stibogluconate vs. sodium stibogluconate injections for the treatment of cutaneous leishmaniasis. A ...
Pages: 53-57
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INVESTIGATIVE REPORT
Knowledge and Influence of Predatory Journals in Dermatology: A Pan-Austrian Survey
Georg Richtig, Markus Richtig, Wolfram Hoetzenecker, Werner Saxinger, Bernhard Lange-Asschenfeldt, Andreas Steiner, Robert Strohal, Christian Posch, Johann W. Bauer, Robert R. Müllegger, Teresa Deinlein, Norbert Sepp, Beatrix Volc-Platzer, Van Anh Nguyen, Matthias Schmuth, Christoph Hoeller, Gudrun Pregartner, Erika Richtig
The aim of this study was to assess the knowledge and influence of predatory journals in the field of dermatology in Austria. A total of 286 physicians (50.5% men) completed a questionnaire. The vast majority of subjects read scientific articles (n = 281, 98.3%) and took them into consideration in their clinical decision-making (n = 271, 98.5% of participants that regularly read scientific ...
Pages: 58-62
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INVESTIGATIVE REPORT
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin
Lydia Brandl, Daniela Hartmann, Thomas Kirchner, Antje Menssen
Deregulated Hedgehog signalling is a driver of basal cell carcinomas. One effector of the Hedgehog pathway is n-MYC. c/n-MYC proteins, NAMPT and DBC1 are linked to SIRT1 in a positive feedback loop that may contribute to tumorigenesis of basal cell carcinoma. In 5 basal cell carcinoma types immunohistochemistry revealed n-MYC, NAMPT and SIRT1 expression. DBC1 was homogenously expressed in all epit ...
Pages: 63-71
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INVESTIGATIVE REPORT
Mortality in Patients with Bullous Pemphigoid: A Retrospective Cohort Study, Systematic Review and Meta-analysis
Khalaf Kridin, Wesal Shihade, Reuven Bergman
There is little consensus regarding mortality data in bullous pemphigoid (BP). The aim of this study was to evaluate mortality among a relatively large cohort of Israeli patients with BP and to perform a meta-analysis synthesizing existing data on 1-year mortality rates of patients with BP. This retrospective cohort study of 287 patients diagnosed with BP between 2000 and 2015 compared the mortali ...
Pages: 72-77
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INVESTIGATIVE REPORT
Granular IgA Deposits in the Skin of Patients with Coeliac Disease: Is it Always Dermatitis Herpetiformis?
Veronica Bonciolini, Emiliano Antiga, Beatrice Bianchi, Elena Del Bianco, Alessandra Ninci, Vincenza Maio, Nicola Pimpinelli, Marzia Caproni
Coeliac disease is an immune-mediated enteropathy driven by gluten, which can be associated with dermatitis herpetiformis. The presence of granular IgA deposits, detected by direct immunofluorescence, is the hallmark of dermatitis herpetiformis; nevertheless, IgA deposits have also been demonstrated in healthy skin of patients with coeliac disease. The main objective of this study was to investiga ...
Pages: 78-83
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INVESTIGATIVE REPORT
Identification of a Single Nucleotide Polymorphism in NFKBIA with Different Effects on Psoriatic Arthritis and Cutaneous Psoriasis in China
Qing Zhao, Yonghu Sun, Xi’an Fu, Zhenzhen Wang, Gongqi Yu, Zhenhua Yue, Yaru Wang, Huimin Zhang, Chuan Wang, Hong Liu, Qing Yang, Furen Zhang
Genome-wide association studies have recently identified a number of non-major histocompatibility complex regions associated with psoriatic arthritis. However, data on Chinese patients with psoriatic arthritis and the differences between psoriatic arthritis and cutaneous psoriasis are limited. This study genotyped 12 single nucleotide polymorphisms in 379 patients with psoriatic arthritis, 376 wit ...
Pages: 84-88
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INVESTIGATIVE REPORT
A Myxoid Fibrotic Reaction Pattern is Associated with Metastatic Risk in Cutaneous Squamous Cell Carcinoma
Eugenia Hernández-Ruiz, Inmaculada Hernández-Muñoz, Emili Masferrer, Carla Ferrándiz-Pulido, Evelyn Andrades, Javier Gimeno, Xavier Duran, Vicente García-Patos, Ramon M. Pujol, Agusti Toll
Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carci ...
Pages: 89-94
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SHORT COMMUNICATION
Acquired Partial Lipodystrophy Associated with Anti-Mi-2 Antibody-positive Adult-onset Dermatomyositis
Ken Shiraishi, Mikiko Tohyama, Koji Sayama
Abstract is missing (Short communication)
Pages: 95-96
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SHORT COMMUNICATION
Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome
Ryoko Kimura, Kazunari Sugita, Hiroyuki Goto, Osamu Yamamoto
Abstract is missing (Short Communication)
Pages: 97-98
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SHORT COMMUNICATION
Langerhans Cell Histiocytosis with Lymph Node Involvement Presenting as Erythroderma
Huiqin Zhu, Yannan Ma, Ling Sun, Rongxin Zhang, Li Lv, Aoxue Wang
Abstract is missing (Short communication)
Pages: 99-100
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SHORT COMMUNICATION
Evaluation of Single Nucleotide Variants in Ethiopian Patients with Atopic Dermatitis
Samina Asad, Isabel Tapia-Páez, Andrea Montano Montes, Carl-Fredrik Wahlgren, Kassahun D. Bilcha, Magnus Nordenskjöld, Maria Bradley
Abstract is missing (Short communication)
Pages: 101-102
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SHORT COMMUNICATION
Increase in FoxP3-positive Cells and Their Contacts with Mast Cells in Köbner-negative Patients with Psoriasis after Tape-stripping
Mireille-Maria Suttle, Riikka-Liisa Ritanen, Ilkka T. Harvima
Abstract is missing (Short communication)
Pages: 103-104
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SHORT COMMUNICATION
Novel Compound Heterozygous Mutations in RAG1 in a Patient with Cutaneous Lymphoproliferative Disease
Cong-cong Xu, Ming Zhi Chen, Jing-shu Xiong, Lu Gan, Ying Zhang, Hao Chen, Jian-Fang Sun
Abstract is missing (Short Communication
Pages: 105-106
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SHORT COMMUNICATION
Unresectable Non-metastatic Primary Melanoma: Complete Remission Following Treatment with Anti-Programmed-cell-death-receptor 1
Coralie Lheure, Caroline Hoffmann, Nora Kramkimel, Julie Plée, Nathalie Franck, Clélia Vanhaecke, Gabrielle Goldman-Lévy, Guillaume Bataillon, Diane Damotte, Nicolas Dupin, Selim Aractingi, Florent Grange, Sarah Guégan
Abstract is missing (Short communication)
Pages: 107-108
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SHORT COMMUNICATION
Intergluteal Contour Deformity in Hidradenitis Suppurativa
Maria Letizia Musumeci, Giulia Capuzzo, Barbara Cammisuli, Antonio Pesce, Alessandra Scilleta, Giuseppe Micali
Abstract is missing (Short communication)
Pages: 109-110
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SHORT COMMUNICATION
A Case of Ankyloblepharon-ectodermal Defects-cleft Lip/Palate-syndrome with Choanal Atresia and Skin Erosions: Phenotypic Variability of TP63-related Disorders
Luana Niculescu, Matias Wagner, Dominik S. Westphal, Marcus Fischer, Walter Mihatsch, Anke Prothmann, Thomas Ruzicka, Andreas Wollenberg, Hans Wolff, Heinrich Schmidt, Kathrin A. Giehl
Abstract is missing (Short communication)
Pages: 111-112
Abstract  PDF
SHORT COMMUNICATION
Schöpf-Schulz-Passarge Syndrome: Previously Unreported WNT10A Genotype and Phenotypes in 9 Family Members
Corinna E. Zimmermann, Muhidien Soufi, Volker Ruppert, Juergen R. Schaefer, Helmut von Domarus
Abstract is missing (Short communication)
Pages: 113-114
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SHORT COMMUNICATION
A Postzygotic ATP2A2 Novel Mutation Identified by Next-generation Sequencing in Mosaic Darier Disease
Liliana Guerra, Cristina Pedicelli, Vittoria Proto, Angelo Giuseppe Condorelli, Cinzia Mazzanti, Daniele Castiglia
Abstract is missing (Short Communication)
Pages: 115-116
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SHORT COMMUNICATION
Two Novel Mutations in the ERCC8 Gene in a Patient with Ultraviolet-sensitive Syndrome
Yue Li, Luyao Zheng, Fuying Chen, Zhirong Yao, Ming Li
Abstract is missing (Short communication)
Pages: 117-118
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QUIZ
Bizarre Pigmented Lesion on the Scalp: A Quiz
Giuseppe Micali, Anna Elisa Verzì, Elisabetta D'Agata, Francesco Lacarrubba
Abstract is missing (Quiz)
Pages: 119-120
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QUIZ
Rapidly Growing Tumour on the Forearm of an 83-year-old Woman: A Quiz
Chakib El Habnouni, Hélène Cornillier, Valérie Tauveron, Serge Guyetant, Annabel Maruani
Abstract is missing (Quiz)
Pages: 121-122
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QUIZ
Disseminated Erythematous Papules and Pustules: A Quiz
Yasuyuki Fujita, Chihiro Shiiya, Yuka Inamura-Takashima, Toshifumi Nomura, Akihiko Shibaki, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 123-124
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