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INVESTIGATIVE REPORT
Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin
Lydia Brandl, Daniela Hartmann, Thomas Kirchner, Antje Menssen
Deregulated Hedgehog signalling is a driver of basal cell carcinomas. One effector of the Hedgehog pathway is n-MYC. c/n-MYC proteins, NAMPT and DBC1 are linked to SIRT1 in a positive feedback loop that may contribute to tumorigenesis of basal cell carcinoma. In 5 basal cell carcinoma types immunohistochemistry revealed n-MYC, NAMPT and SIRT1 expression. DBC1 was homogenously expressed in all epit ...
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SHORT COMMUNICATION
A Case of Ankyloblepharon-ectodermal Defects-cleft Lip/palate-syndrome with Choanal Atresia and Skin Erosions: Phenotypic Variability of TP63-related Disorders
Luana Niculescu, Matias Wagner, Dominik S. Westphal, Marcus Fischer, Walter Mihatsch, Anke Prothmann, Thomas Ruzicka, Andreas Wollenberg, Hans Wolff, Heinrich Schmidt, Kathrin A. Giehl
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
A Myxoid Fibrotic Reaction Pattern is Associated with Metastatic Risk in Cutaneous Squamous Cell Carcinoma
Eugenia Hernández-Ruiz, Inmaculada Hernández-Muñoz, Emili Masferrer, Carla Ferrándiz-Pulido, Evelyn Andrades, Javier Gimeno, Xavier Duran, Vicente García-Patos, Ramon M. Pujol, Agusti Toll
Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carci ...
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SHORT COMMUNICATION
Acquired Partial Lipodystrophy Associated with Anti-Mi-2 Antibody-positive Adult-onset Dermatomyositis
Ken Shiraishi, Mikiko Tohyama, Koji Sayama
Abstract is missing (Short communication)
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REVIEW
Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review
Elisabeth B.M. Petersen, Lone Skov, Jacob P. Thyssen, Peter Jensen
The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, ...
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CLINICAL REPORT
Prevalence of Psoriasis and Psoriatic Arthritis and Patient Perceptions of Severity in Sweden, Norway and Denmark: Results from the Nordic Patient Survey of Psoriasis and Psoriatic Arthritis
Kjersti Danielsen, Albert Duvetorp, Lars Iversen, Mikkel Østergaard, Oliver Seifert, Kåre Steinar Tveit, Lone Skov
Optimal clinical management of psoriasis and psoriatic arthritis (PsA) Optimal clinical management of psoriasis and psoriatic arthritis (PsA) requires understanding of the impact on patients. The NORdic PAtient survey of Psoriasis and PsA (NORPAPP) aimed to obtain current data on disease prevalence and patient perceptions in Sweden, Denmark and Norway. Among 22,050 individuals questioned, the repo ...
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SPECIAL REPORT
Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis
Solam Lee, Young Bin Lee, Sung Jay Choe, Won-Soo Lee
Treatment of male androgenetic alopecia with 5α-reductase inhibitors is efficacious. However, the risk of adverse sexual effects remains controversial. This systematic review and meta-analysis investigated the risk of adverse sexual effects due to treatment of androgenetic alopecia in male patients with finasteride, 1 mg/day, or dutasteride, 0.5 mg/day. Fifteen randomized double-blinded placebo-c ...
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CLINICAL REPORT
Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation
Ignacio Gómez-Martín, Sara Moreno, Xavier Duran, Ramon M. Pujol, Sonia Segura
Pink flat skin lesions on the legs in elderly people represent a diagnostic challenge due to the paucity of clinical and dermoscopic evidence. A prospective study of 114 pink flat lesions on the legs of 85 elderly patients was performed to describe the utility of reflectance confocal microscopy in this clinical context. Evaluation of clinical, dermoscopic and confocal parameters and calculation of ...
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INVESTIGATIVE REPORT
Identification of a Single Nucleotide Polymorphism in NFKBIA with Different Effects on Psoriatic Arthritis and Cutaneous Psoriasis in China
Qing Zhao, Yonghu Sun, Xi’an Fu, Zhenzhen Wang, Gongqi Yu, Zhenhua Yue, Yaru Wang, Huimin Zhang, Chuan Wang, Hong Liu, Qing Yang, Furen Zhang
Genome-wide association studies have recently identified a number of non-major histocompatibility complex regions associated with psoriatic arthritis. However, data on Chinese patients with psoriatic arthritis and the differences between psoriatic arthritis and cutaneous psoriasis are limited. This study genotyped 12 single nucleotide polymorphisms in 379 patients with psoriatic arthritis, 376 wit ...
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SHORT COMMUNICATION
Unresectable Non-metastatic Primary Melanoma: Complete Remission Following Treatment with Anti-Programmed-cell-death-receptor 1
Coralie Lheure, Caroline Hoffmann, Nora Kramkimel, Julie Plée, Nathalie Franck, Clélia Vanhaecke, Gabrielle Goldman-Lévy, Guillaume Bataillon, Diane Damotte, Nicolas Dupin, Selim Aractingi, Florent Grange, Sarah Guégan
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Langerhans Cell Histiocytosis with Lymph Node Involvment Presenting as Erythroderma
Huiqin Zhu, Yannan Ma, Ling Sun, Rongxin Zhang, Li Lv, Aoxue Wang
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Two Novel Mutations in the ERCC8 Gene in a Patient with Ultraviolet-sensitive Syndrome
Yue Li, Luyao Zheng, Fuying Chen, Zhirong Yao, Ming Li
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Granular IgA Deposits in the Skin of Patients with Coeliac Disease: Is it Always Dermatitis Herpetiformis?
Veronica Bonciolini, Emiliano Antiga, Beatrice Bianchi, Elena Del Bianco, Alessandra Ninci, Vincenza Maio, Nicola Pimpinelli, Marzia Caproni
Coeliac disease is an immune-mediated enteropathy driven by gluten, which can be associated with dermatitis herpetiformis. The presence of granular IgA deposits, detected by direct immunofluorescence, is the hallmark of dermatitis herpetiformis; nevertheless, IgA deposits have also been demonstrated in healthy skin of patients with coeliac disease. The main objective of this study was to investiga ...
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SHORT COMMUNICATION
A Postzygotic ATP2A2 Novel Mutation Identified by Next-generation Sequencing in Mosaic Darier Disease
Liliana Guerra, Cristina Pedicelli, Vittoria Proto, Angelo Giuseppe Condorelli, Cinzia Mazzanti, Daniele Castiglia
Abstract is missing (Short Communication)
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QUIZ
Disseminated Erythematous Papules and Pustules: A Quiz
Yasuyuki Fujita, Chihiro Shiiya, Yuka Inamura-Takashima, Toshifumi Nomura, Akihiko Shibaki, Hiroshi Shimizu
Abstract is missing (Quiz)
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CLINICAL REPORT
Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study
Liv Kroona, Marléne Isaksson, Camilla Ahlgren, Jakob Dahlin, Magnus Bruze, Gunnar Warfvinge
Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch-tested patients at the Malmö clinic, for the period 1996 to 2016, w ...
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SHORT COMMUNICATION
Diagnostic Value of T-SPOT.TB Test in Cutaneous Mycobacterial Infections
Yanqing Chen, Haiqin Jiang, Wenyue Zhang, Zhiming Chen, Youming Mei, Hao Chen, Ying Shi, Wei Gao, Lei Wang, Santosh Chokkakula, Hongsheng Wang
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Clinical Experience of Overnight use of a Temperature-controlled Airflow Device in a Teenager with Severe Atopic Dermatitis
Grigorios Theodosiou, Åke Svensson
Abstract is missing (Short Communication)
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QUIZ
Congenital Nodule on the Ear in a Two-year-old Boy: A Quiz
Ayano Ikeda, Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto
Abstract is missing (Quiz)
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SHORT COMMUNICATION
A Case of Subcutaneous Infection with Mycobacterium mageritense Identified by Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry
Tomohiro Oiwa, Teruasa Murata, Tetsuya Honda, Satoshi Nakano, Kenji Kabashima
Abstract is missing (Short communication)
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CLINICAL REPORT
Longer Duration of Untreated Psychosis is Associated with Poorer Outcomes for Patients with Delusional Infestation
Dmitry V. Romanov, Peter Lepping, Anthony Bewley, Markus Huber, Roland W. Freudenmann, Andrey Lvov, Stephen Bertel Squire, Eric O. Noorthoorn
We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. This multi-centre international study included 211 consecutive patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at baseline and follow-up. A regression analysis showed a clear clinical a ...
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CLINICAL REPORT
Achieving Hidradenitis Suppurativa Response Score (HiSCR) Is Associated With Significant Improvement in Clinical and Patient-Reported Outcomes: Post Hoc Analysis of Pooled Data From PIONEER I and II
Alexandra B. Kimball, Thrasivoulos Tzellos, Brian M. Calimlim, Henrique D. Teixeira, Ziqian Geng, Martin M. Okun
Hidradenitis Suppurativa Clinical Response (HiSCR), is a validated tool that has been used to assess the efficacy of adalimumab among patients with hidradenitis suppurativa. We evaluated the clinical meaning of HiSCR by relating it to patient-reported outcomes to give further context to its achievement in a post hoc analysis of integrated data from two phase 3 clinical trials (PIONEER I and II). P ...
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CLINICAL REPORT
Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma
Verena G. Frings, Kristina Röding, Alexander Strate, Andreas Rosenwald, Sabine Roth, Hermann Kneitz, Matthias Goebeler, Eva Geissinger, Marion Wobser
Primary cutaneous marginal zone lymphomas (PCMZL) frequently exhibit lymphoplasmacytoid/plasmacytic differentiation, implying the capacity to produce monoclonal immunoglobulins. As these paraproteins are secreted, and thus are measurable in blood and urine, they may correlate with disease burden and serve as tumour markers reflecting therapeutic response. This study retrospectively analysed the re ...
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CLINICAL REPORT
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain
Isabel Rodríguez-Blanco, Ángeles Flórez, Carmen Paredes-Suárez, Romina Rodríguez-Lojo, Daniel González-Vilas, Aquilina Ramírez-Santos, Sabela Paradela, Ignacio Suárez Conde, Manuel Pereiro-Ferreirós
Actinic cheilitis is thought to be a premalignant lesion or a superficial squamous cell carcinoma. The prevalence of actinic cheilitis in Europe is unknown. The aim of this study was to determine the prevalence of actinic cheilitis in the Galicia region (north-west Spain). Secondary objectives were the description of risk factors of actinic cheilitis. A cross-sectional multicentre study in patient ...
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CLINICAL REPORT
Treatment of Early Folliculotropic Mycosis Fungoides with Special Focus on Psoralen plus Ultraviolet A
Iris Amitay-Laish, Hadas Prag-Naveh, Adam Dalal, Lev Pavlovsky, Meora Feinmesser, Emmilia Hodak
Data on the treatment of early folliculotropic mycosis fungoides, a recently defined clinicopathological subgroup of folliculotropic mycosis fungoides with an indolent course, is limited. Treatment outcomes were studied in a retrospective cohort of 47 adults with early folliculotropic mycosis fungoides, with a focus on psoralen plus ultraviolet A (PUVA) monotherapy, including dosimetric data, and ...
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CLINICAL REPORT
Assessment of the Effect of 3% Diclofenac Sodium on Photodamaged Skin by Means of Reflectance Confocal Microscopy
Gonzalo Segurado-Miravalles, Natalia Jiménez-Gómez, Oscar Muñoz Moreno-Arrones, Ivette Alarcón-Salazar, Adrian Alegre-Sánchez, David Saceda-Corralo, Pedro Jaén-Olasolo, Salvador González-Rodríguez
Treatment of actinic keratosis with 3% diclofenac sodium w/w in hyaluronic acid is associated with a concomitant improvement in signs of photodamaged skin. However this effect has not yet been examined in depth. Twenty patients with actinic keratosis and signs of photodamaged skin were studied. They received treatment with diclofenac sodium w/w in hyaluronic acid for 2 months. Clinical and reflect ...
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REVIEW
Melanogenesis Inhibitors
Sulekha Kumari, Steven Tien Guan Thng, Navin Kumar Verma, Hemant K. Gautam
Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly impact an individual’s appearance, and may cause emotional and psychological distress and reduced quality of life. A large number of melanogenesis inhibitors have been developed, b ...
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SHORT COMMUNICATION
Tuberculosis Screening in Patients with Psoriasis Receiving Biologic Therapy: A Retrospective Cohort Study
Igor Snast, Einav Bercovici, Tomer Avni, Dorit Shitenberg, Emmilia Hodak, Lev Pavlovsky
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid: Recurrence with Epitope Spreading
Hiroyuki Takama, Makiko Yoshida, Kentaro Izumi, Takeshi Yanagishita, Jun Muto, Yuichiro Ohshima, Wataru Nishie, Hiroshi Shimizu, Masashi Akiyama, Daisuke Watanabe
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Secondary Cutaneous Epstein–Barr Virus-associated Diffuse Large B-cell Lymphoma with Hodgkin/Reed-Sternberg-like Cells in a Patient with Angioimmunoblastic T-cell Lymphoma
Hao Chen, Yan-ning Xue, Chong-mei Xin, Jing-shu Xiong, Xiao Ni, Jian-Fang Sun
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England
Peter K.C. Goon, Puran Gurung, Nick J. Levell, Priya Subramanian, Adrian S.W. Yong, Kevin Y.C. Lee, Laszlo Igali, David Greenberg, Syed N. Shah, Eunice K.H. Tan
Abstract is missing (Short communication)
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SHORT COMMUNICATION
A Case of Pityriasis Rubra Pilaris Treated Successfully with the Phosphodiesterase-4 Inhibitor Apremilast
Maria Cho, Tetsuya Honda, Chiyuki Ueshima, Tatsuki Kataoka, Atsushi Otsuka, Kenji Kabashima
Abstract is missing (Short commuication)
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REVIEW
Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis
Masutaka Furue, Akiko Hashimoto-Hachiya, Gaku Tsuji
Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signall ...
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CLINICAL REPORT
Nocebo Effects and Scratching Behaviour on Itch
Danielle J.P. Bartels, Antoinette I.M. van Laarhoven, Peter C.M. van de Kerkhof, Andrea W.M. Evers
Nocebo effects, i.e. reduced treatment effects due to patients’ negative expectations, play a role in itch. Recent studies have shown that nocebo effects can be induced experimentally on itch and also be minimized and even turned into the opposite direction, i.e. placebo effects. It is not known whether these effects generalize to itch-associated scratching behaviour. The aim of this study was t ...
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SHORT COMMUNICATION
Changes in Androgen Receptor Expression as a Molecular Marker of Progression from Normal Epithelium to Invasive Cancer in Elderly Patients with Penile Squamous Cell Carcinoma
Valerio Gaetano Vellone, Emanuele Cozzani, Leonardo Peñuela, Roberto Russo, Bruno Spina, Carlo Toncini, Carlo Terrone, Aurora Parodi
Abstract is missing (Short Communication)
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INVESTIGATIVE REPORT
Modulation of Itch by Localized Skin Warming and Cooling
Kristen M. Sanders, Takashi Hashimoto, Kent Sakai, Tasuku Akiyama
Skin thermal changes modulate itch sensitivity. However, the mechanisms of this modulation are still unclear. Using mouse models of acute and chronic itch, we investigated whether local innocuous thermal stimulation of the skin alters itch sensitivity and if blockade of thermosensitive transient receptor potential (TRP) channels can reduce these changes. Localized thermal changes were achieved by ...
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SHORT COMMUNICATION
Efficacy of Oral Ruxolitinib in a Patient with Refractory Chronic Spontaneous Urticaria
Atsushi Fukunaga, Mitsuhiro Ito, Chikako Nishigori
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Methotrexate for the Treatment of Recalcitrant Primary Localized Cutaneous Amyloidosis: A Case Series
Carolyn M. Stull, Hong Liang Tey, Gil Yosipovitch
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo
Antony R. Young, Jessica Greenaway, Graham I. Harrison, Karl P. Lawrence, Robert Sarkany, Thierry Douki, France Boyer, Gwendal Josse, Emmanuel Questel, Camille Monteil, Ana B. Rossi
The cyclobutane pyrimidine dimer (CPD) is a potentially mutagenic DNA photolesion that is the basis of most skin cancers. There are no data on DNA protection by sunscreens under typical conditions of use. The study aim was to determine such protection, in phototypes I/II, with representative sunscreen-user application. A very high SPF formulation was applied at 0.75, 1.3 and 2.0 mg/cm2. Unprotecte ...
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SHORT COMMUNICATION
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis
Kati Hokynar, Alexander Salava, Eero Vesterinen, Antti Lauerma, Annamari Ranki, Mirja Puolakkainen
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Effects of Film Dressings on Itch Hypersensitivity Using Murine Dry Skin Models
Tomoyuki Iwanaga, Mitsutoshi Tominaga, Yui Hirata, Hironori Matsuda, Tomomasa Shimanuki, Hideoki Ogawa, Kenji Takamori
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Nanostring Analysis of Skin Biopsies from Patients with Henoch-Schönlein Purpura Reveals Genes Associated with Pathology and Heterogeneity in the Disease Process
Yingrou Tan, Jackson Liang Yao Li, Bernett Teck Kwong Lee, Josephine Lum, Zacharias Aloysius Dwi Pramono, Maximilien Evrard, Michael Poidinger, Hong Liang Tey, Lai Guan Ng
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Genotype–Phenotype Correlations of Dystrophic Epidermolysis Bullosa in India: Experience from a Tertiary Care Centre
Vamsi K. Yenamandra, Shamsudheen K. Vellarikkal, Madhumita R. Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata Basu Ray, Amit K. Dinda, Madhulika Kabra, Vinod K. Sharma, Gomathy Sethuraman
Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing as a rapid and efficient diagnostic strategy in several genodermatoses. The aim of this study was to explore the potential of molecular studies in dystrophic epidermolysis bullosa (DEB) in India. Whole exome sequencing was performed using genomic DNA from each case of epidermolysis bullosa, f ...
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CLINICAL REPORT
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options
Emma Gardette, Philippe Moguelet, Jean-David Bouaziz, Dan Lipsker, Olivier Dereure, Francois Le Pelletier, Catherine Lok, Thierry Maisonobe, Didier Bessis, Jacqueline Conard, Camille Francès, Stéphane Barete
Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopathy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically. Investigation of thrombophilia was performed. Electromyography was undertaken in the presence of symptoms suggestin ...
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SHORT COMMUNICATION
Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis
Emi Mashima, Yu Sawada, Akiha Inoue, Natsuko Saito-Sasaki, Takashi Yamaguchi, Haruna Yoshioka, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Etsuko Okada, Motonobu Nakamura
Abstract is missing (Short Communication)
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SHORT COMMUNICATION
A Nodular Hidradenoma of Atypical Location in Pregnancy
Chen Yao, Michael G. Swaby, Michael R. Migden, Sirunya Silapunt
Abstract is missing (Short Communication)
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SHORT COMMUNICATION
Premature Aging Syndrome, Penttinen Type: Report of a Chinese Case with a PDGFRB Mutation
Zhiyong Zhang, Shuguang Zheng, Song Zheng, Yanyan Wang, Xue-Gang Xu, Xing-Hua Gao, Hong-Duo Chen
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Disfiguring Leukoderma Caused by Banned Cosmetics: A Quiz
Laura Atzori, Ramona Zanniello, Giorgia Sarais, Viviana Piras, Luca Pilloni, Myriam Zucca, Maria Angela Brundu, Franco Rongioletti
Abstract is missing (Quiz)
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CLINICAL REPORT
Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study
Marie-Charlotte Brüggen, Katrin Kerl, Eugenia Haralambieva, Urs Schanz, Yun-Tsan Chang, Desislava Ignatova, Reinhard Dummer, Antonio Cozzio, Wolfram Hoetzenecker, Lars E. French, Emmanuella Guenova
Rare T- or NK-cell lymphomas with cutaneous manifestation may display a highly aggressive clinical course and major diagnostic/therapeutic challenges. This report describes our experiences with different lymphomas of this rare category and the therapeutic options used. This retrospective, descriptive, monocentric, cross-sectional case study, identified 4 rare aggressive T-/NK-cell lymphomas with m ...
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CLINICAL REPORT
Safety Profile of Secukinumab in Treatment of Patients with Psoriasis and Concurrent Hepatitis B or C: A Multicentric Prospective Cohort Study
Hsien-Yi Chiu, Rosaline Chung-yee Hui, Yu-Huei Huang, Ruey-Yun Huang, Kai-Lung Chen, Ya-Chu Tsai, Po-Ju Lai, Ting-Shun Wang, Tsen-Fang Tsai
Safety data for secukinumab in patients with psoriasis and viral hepatitis are lacking. The aim of this study is to investigate the risk of reactivation of hepatitis B virus (HBV)/hepatitis C virus (HCV) in patients with psoriasis who are receiving secukinumab therapy. This multicentre study screened 284 patients with psoriasis with available HBV and HCV serological data and 63 patients with concu ...
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INVESTIGATIVE REPORT
Methotrexate Exposure and Risk of Cutaneous Malignant Melanoma: No Evidence of a Dose-response Relationship
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Methotrexate treatment has been linked with an increased risk of melanoma. However, a possible dose-response relationship with respect to methotrexate exposure and melanoma has not been addressed. The aim of the present study was to investigate whether higher accumulated doses of methotrexate correlate with an increased risk of melanoma, which would further support a possible association. A nation ...
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SHORT COMMUNICATION
Squamous Cell Carcinoma and Multiple Familial Trichoepitheliomas: A Recurrent Association
Anna Dubois, Tiago Mestre, Thomas Oliphant, Akhtar Husain, Neil Rajan
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters
Fani Karagianni, Ching-Ni Njauw, Katerina P. Kypreou, Aravela Stergiopoulou, Michaela Plaka, Dorothea Polydorou, Vasiliki Chasapi, Leontios Pappas, Ioannis A. Stratigos, Gregory Champsas, Peter Panagiotou, Helen Gogas, Evangelos Evangelou, Hensin Tsao, Alexander J. Stratigos, Irene Stefanaki
Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correlate the mutational status with specific clinico-epidemiological characteristics. A cross-sectional study was conducted by genotyping CDKN2A/CDK4 varian ...
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INVESTIGATIVE REPORT
Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder. Immunohistochemistry showed that epidermal expression of androgen receptors, oestrogen receptors (α, β) and progesterone receptors was higher in skin lesions of Becker’s naevus than in perilesional and control skin. Androgen receptor over ...
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BOOK REVIEW
Cutaneous Malignancies. A surgical perspective
Lisa Naysmith
Abstract is missing (Book review)
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BOOK REVIEW
Therapy for Severe Psoriasis, 1st Edition
Lone Skov
Abstract is missing (Book review)
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IN THIS ISSUE
Comment on: Quimp: A word meaning “quality of life impairment”
Pavel V. Chernyshov
Abstract is missing (In this Issue...)
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IN THIS ISSUE
Have you measured the patient’s quimp?
Magnus Lindberg
Abstract is missing (In this Issue...)
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BOOK REVIEW
Neonatal and Infant Dermatology, 3rd edition
Regina Fölster-Holst
Abstract is missing (Book review)
Abstract  PDF