New articles from Acta Dermato-Venereologica Acta Dermato-Venereologica is an international peer-review journal for clinical and experimental research in the field of dermatology and venereology. 95:8 2015 - INDEX 95
2015-10-19 Index
95:8 2015 - ERRATUM
Abstract is missing (Erratum)]]>
2015-09-16 Erratum
95:8 2015 - Brown Nodule on the Lower Eyelid: A Quiz
Abstract is missing (Quiz)]]>
2015-05-12 Quiz
95:8 2015 - Vesicles on the Breast Post-mastectomy: A Quiz
Abstract is missing (Qujiz)]]>
2015-06-17 Quiz
95:8 2015 - Measuring Family Impact of Skin Diseases: FDLQI and FROM-16
Abstract is missing (Letter)]]>
2015-04-28 Letter
95:8 2015 - Comment on Zhao et al. “Palmoplantar Keratoderma of the Gamborg-Nielsen Type is Caused by Mutations in the SLURP1 Gene and Represents a Variant of Mal de Meleda”
Abstract is missing (Letter to the Editor)]]>
2015-07-15 Letter
95:8 2015 - Erythema Annulare Centrifugum Associated with Ovarian Cancer
Abstract is missing (Short communication)]]>
2015-06-11 Shortcom
95:8 2015 - No Major Effect of Cyclosporin A in Patients with Severe Solar Urticaria: A French Retrospective Case Series
Abstract is missing (Short communication)]]>
2015-06-08 Shortcom
95:8 2015 - Disseminated Mycobacterium mantenii Infection with Multiple Purulent Cutaneous Lesions
Abstract is missing (Short communication)]]>
2015-05-19 Shortcom
95:8 2015 - Nail Dystrophy as a Presenting Sign of a Chondrosarcoma of the Distal Phalanx – Case Report and Review of the Literature
Abstract is missing (Short communication)]]>
2015-05-07 Shortcom
95:8 2015 - CD4/CD8 Double-negative T-cell Lymphoma: A Variant of Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma?
Abstract is missing (Short communication)]]>
2015-05-06 Shortcom
95:8 2015 - H Syndrome: A Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis
Abstract is missing (Short communication)]]>
2015-06-08 Shortcom
95:8 2015 - Increased Expression of Caspase-1 and Interleukin-18 in Peeling Skin Disease, and a Novel Mutation of Corneodesmosin
Abstract is missing (Short communication)]]>
2015-06-12 Shortcom
95:8 2015 - Quadrivalent Human Papillomavirus Vaccination: A Promising Treatment for Recalcitrant Cutaneous Warts in Children
Abstract is missing (Short communication)]]>
2015-04-27 Shortcom
95:8 2015 - A Case of Neonatal Linear IgA Bullous Dermatosis with Severe Eye Involvement
Abstract is missing (Short communication)]]>
2015-05-06 Shortcom
95:8 2015 - Childhood Epidermolysis Bullosa Acquisita with Underlying Coeliac Disease
Abstract is missing (Short communication)]]>
2015-05-05 Shortcom
95:8 2015 - Successful Treatment of Lipedematous Alopecia using Mycophenolate Mofetil
Abstract is missing (Short communication)]]>
2015-04-27 Shortcom
95:8 2015 - Effective Palliation of Intractable Bleeding from Noonan Syndrome-associated Lymphatic Malformations by Radiotherapy
Abstract is missing (Short communication)]]>
2015-04-27 Shortcom
95:8 2015 - Large Deletions in the NSDHL Gene in Two Patients with CHILD Syndrome
Abstract is missing (Short communication)]]>
2015-06-08 Shortcom
95:8 2015 - Familial Primary Localized Cutaneous Amyloidosis Results from Either Dominant or Recessive Mutations in OSMR
Abstract is missing (Short communication)]]>
2015-04-22 Shortcom
95:8 2015 - Localized Scleroderma Presenting as Port-wine Stains: Report of Two Cases and a Literature Review
Abstract is missing (Short communication)]]>
2015-04-08 Shortcom
95:8 2015 - Subungual Angiokeratoma Presenting as a Longitudinal Pigmented Band in the Nail
Abstract is missing (Short communication)]]>
2015-03-11 Shortcom
95:8 2015 - Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1)
Abstract is missing (Short communication)]]>
2015-03-19 Shortcom
95:8 2015 - Subtyping Basal Cell Carcinoma by Clinical Diagnosis Versus Punch Biopsy
Abstract is missing (Short communication)]]>
2015-05-28 Shortcom
95:8 2015 - Increased Expression of Integrin α6β4 in the Basement Membrane Zone Lining the Sebaceous Glands in Hidradenitis Suppurativa
Abstract is missing (Short communication)]]>
2015-08-18 Shortcom
95:8 2015 - Naevus Comedonicus Syndrome Complicated by Hidradenitis Suppurativa-like Lesions Responding to Acitretin Treatment
bstract is missing (Short communication)]]>
2015-03-18 Shortcom
95:8 2015 - Hidradenitis Suppurativa Disproportionately Affects African Americans: A Single-center Retrospective Analysis
Abstract is missing (Short communication)]]>
2015-09-15 Shortcom
95:8 2015 - Cutaneous Infections Caused by Rapidly Growing Mycobacteria: Case Reports and Review of Clinical and Laboratory Aspects
Skin and soft tissue infections caused by rapidly growing non-tuberculous mycobacteria (RG-NTM) have become a growing clinical concern over the past decades. These RG-NTM are ubiquitous environmental organisms and most are resistant to traditional antituberculous agents. In this report, we describe 3 cutaneous infections caused by RG-NTM, namely, Mycobacterium abscessus, M. chelonae, and M. conceptionense, and present the clinical and laboratory characteristics of these infections.]]>
2015-06-01 Clinical
95:8 2015 - Pathogenesis of Multiple Lentigines in LEOPARD Syndrome with PTPN11 Gene Mutation
LEOPARD syndrome (LS) is an autosomal dominant condition with multiple anomalies, including multiple lentigines. LS is caused by mutations in PTPN11, encoding the protein tyrosine phosphatase, SHP-2. We report here 2 unrelated Japanese cases of LS with different PTPN11 mutations (p.Y279C and p.T468P). To elucidate the pathogenesis of multiple lentigines in LS, ultrastructural and immunohistochemical analyses of lentigines and non-lesional skin were performed. Numerous mature giant melanosomes in melanocytes and keratinocytes were observed in lentigines. In addition, the levels of expression of endothelin-1 (ET-1), phosphorylated Akt, mTOR and STAT3 in the epidermis in lentigines were significantly elevated compared with non-lesional skin. In in vitro assays, melanin synthesis in human melanoma cells expressing SHP-2 with LS-associated mutations was higher than in cells expressing normal SHP-2, suggesting that LS-associated SHP-2 mutations might enhance melanin synthesis in melanocytes, and that the activation of Akt/mTOR signalling may contribute to this process.]]>
2015-05-19 Clinical
95:8 2015 - Factors Associated with Drug Survival of Methotrexate and Acitretin in Patients with Psoriasis
Drug survival has recently become an important clinical issue in psoriasis. However, there has been little research into factors associated with drug survival of methotrexate and acitretin. The aim of this study was to investigate factors associated with drug survival of methotrexate and acitretin treatment for psoriasis. Survival analysis was performed in patients who received methotrexate or acitretin for the treatment of psoriasis, drawn from the Clalit Health Services database. Investigated factors included demographic variables, obesity, metabolic syndrome, psoriatic arthritis, administration route and folic acid supplementation. Among 6,256 patients, factors associated with treatment drop-out were: younger age (p <0.001) and psoriatic arthritis (acitretin p < 0.001). For methotrexate, metabolic syndrome (p = 0.033), intramuscular administration route of injection (p <0.001) and lack of folic acid supplementation (p <0.001) were associated with treatment drop-out. In patients with psoriasis, some ancillary factors may modify the drug survival of acitretin and methotrexate.]]>
2015-06-30 Clinical
95:8 2015 - Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study
Atopic dermatitis (AD) is a common disease in childhood and an important risk factor for the later development of other atopic diseases. Many publications on childhood AD use questionnaires based on information obtained in adulthood, which introduce the possibility of recall bias. In a prospective cohort study, recall bias was evaluated in 1,501 unselected schoolchildren (mean age 14 years) evaluated for the first time in 1995 with a standardized questionnaire combined with a clinical examination and repeated in 2010. The lifetime prevalence of AD was 34.1% including data obtained both during school age and 15 years later, compared with 23.6% including data only from adulthood. The most important factors for remembering having had AD in childhood were: (i) long duration of dermatitis in childhood; (ii) adult hand eczema; and (iii) concomitant atopic disease. Recall bias for childhood AD affected the results of logistic regression on adult hand eczema and is a significant problem in retrospective epidemiological questionnaire studies evaluating previous AD as a risk factor for development of other diseases. ]]>
2015-05-28 Clinical
95:8 2015 - Serum Creatinine Levels During and After Long-term Treatment with Cyclosporine A in Patients with Severe Atopic Dermatitis
Safety data with respect to kidney function during long-term treatment with cyclosporine A (CsA) in patients with atopic dermatitis is limited. Data on serum creatinine levels before, during and after CsA treatment were collected in a retrospective cohort of adult patients with atopic dermatitis. The median duration of treatment of 150 patients was 280 days (interquartile range 203–528 days). There was a significant, but not clinically relevant, increase in serum creatinine compared with the baseline level after 3 weeks of treatment with CsA and stabilization during the maintenance phase at the group level. Twenty-two (14.7%) patients had a greater than 30% increase in serum creatinine (cut-off point for clinically relevant change) compared with baseline. These patients were significantly older than the patients without a 30% increase (mean ± standard deviation age 41.4 ± 15.6 vs. 33.8 ± 11.7 years (p = 0.01)). During follow-up, all patients had a less than 30% increase in serum creatinine levels compared with baseline levels. At the group level serum creatinine levels during follow-up were not significantly different from baseline.]]>
2015-05-19 Clinical
95:8 2015 - Self-reported Occupational Exposure to Chemical and Physical Factors and Risk of Skin Problems: A 3-year Follow-up Study of the General Working Population of Norway
Prospective studies on occupational dermatoses in the general working population are sparse. This study investigated prospectively the impact of self-reported occupational exposure to chemicals and physical factors on the risk of skin problems. The cohort comprised respondents drawn randomly from the general population in Norway, who were registered employed in 2006 and 2009 (n = 6,745). Indoor dry air (odds ratio (OR) 1.3; 95% confidence interval (95% CI) 1.1–1.6) was a significant baseline predictor of skin problems at follow-up, whereas exposure to cleaning products (OR 1.7; 95% CI 1.2–2.5), water (OR 1.4; 95% CI 1.1–1.9) and indoor dry air (OR 1.6; 95% CI 1.1–2.1) at both measurement time-points was significantly associated with skin problems. The population risk attributable to these factors was 16%. This study quantified the contribution of occupational exposure factors to skin problems in the general working population of Norway. ]]>
2015-06-03 Investigative
95:8 2015 - Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet’s Disease Patients and a Behçet’s Disease-like Mouse Model
Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet’s disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.]]>
2015-05-26 Investigative
95:8 2015 - Regional Diffusion of Botulinum Toxin in Facial Muscles: A Rando­mised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
Despite the extensive use of botulinum toxin A (BoNTA) in medical and cosmetic treatments, the potential spreading of BoNTA to surrounding tissues remains unknown. A patient with hemifacial paralysis upon blepharospasm treatment with low dose of BoNTA, prompted us to investigate the spreading effect. A randomised, double-blind study was conducted in which 5 healthy women (33–52 years) were treated with different doses of onabotulinum toxin unilaterally in the corrugator muscle. Parameters of efficacy and diffusion (CMAP; EMG and jitter analysis) in both glabellar and frontalis muscles were assessed at baseline, 2 and 4 weeks following BoNTA injection. CMAP of the treated glabellar muscles was reduced to approximately 40% in all dose groups. Additionally, contralateral CMAP reduction was observed in 3 of 5 subjects. These data confirm regional diffusion of BoNTA in facial muscle application, which raises question on the reliability of split-face models in BoNTA studies.]]>
2015-04-22 Investigative
95:8 2015 - High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis
Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14–78 years) with a mean follow-up of 4.15 years. High baseline IgE (≥ 10,000 IU/ml) was the most important patient-related factor for a poor long-term outcome, being negatively associated with good treatment response (odds ratio (OR) 0.062, p = 0.002). Only 14.3% of patients with this high baseline IgE achieved a good treatment response in follow-up, compared with 79.7% in patients with lower (< 1,000) IgE values (p < 0.001). Serum total IgE may provide an easily measurable way to predict long-term outcome, and to help to select those patients in need of closer follow-up.]]>
2015-05-26 Investigative
95:8 2015 - Role of Age and Sex in the Diagnosis of Early-stage Malignant Melanoma: A Cross-Sectional study
Age and sex have been identified as predictors of outcome in malignant melanoma (MM). This aim of this multicentre, cross-sectional study was to analyse the role of age and sex as explanatory variables for the diagnosis of thin MM. A total of 2430 patients with MM were recruited. Cases of in situ-T1 MM were more frequent than T2–T4 MM (56.26% vs. 43.74%). Breslow thickness increased throughout decades of life (analysis of variance (ANOVA) p < 0.001), with a weak correlation between Breslow thickness and patient’s age (r   = 0.202, p < 0.001). Breslow thickness was significantly less in women (1.79 vs. 2.38 mm, p = 0.0001). Binary logistic regression showed a significant (p < 0.001) odds ratio for age 0–29 years (1.18), and 30–59 years (1.16), and for women (1.09). Age and sex explained 3.64% of the variation observed in Tis-T1 frequency (R2 = 0.0364). Age and sex appear to explain a low percentage of the variation in the early detection of MM.]]>
2015-05-26 Investigative
95:8 2015 - The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review
Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids appears more efficient than emollients only, at least for short-time treatments. Despite higher efficacy, there is a tendency towards more frequent infections when topical corticosteroids are covered with wet wrap bandages compared to emollients only. While temporary suppression of hypothalamic-pituitary-adrenocortical-axis was seen due to systemic bioactivity of corticosteroids, no long-term observation studies on putative adverse effects were identified. One hypothesis suggests that wet wrap therapy may trigger increased lamellar body secretion resulting in recovery of the damaged intercellular lipid laminar structure. Otherwise, little investigation on mechanisms exists.]]>
2015-06-01 Clinical
95:8 2015 - Efficacy of Rituximab for Pemphigus: A Systematic Review and Meta-analysis of Different Regimens
This meta-analysis examined the efficacy of different dosing regimens containing rituximab (RTX) in treating pemphigus. The analysis included 578 patients with pemphigus from 30 studies. Seventy-six percent of patients achieved complete remission (CR) after 1 cycle of RTX. Mean time to remission was 5.8 months, with a remission duration of 14.5 months and a 40% relapse rate. Eighteen patients (3.3%) developed serious adverse effects. The pooled estimate showed no significant differences in CR and relapse rates between patients treated with high-dose (near or ≥ 2,000 mg/cycle) vs. low-dose (< 1,500 mg/cycle) RTX. In the fully adjusted analysis, high-dose RTX was associated with longer duration of CR compared with low-dose RTX. No superiority of lymphoma protocol over rheumatoid arthritis or high-dose RTX over low-dose RTX was shown in other outcomes. RTX treatment is efficacious and well-tolerated in treating pemphigus. High-dose RTX treatment may lead to longer duration of remission. However, the choice of optimal regimen depends on the overall condition of the individual patient.]]>
2015-05-22 Special
95:8 2015 - Increased Risk of Melanoma in Organ Transplant Recipients: Systematic Review and Meta-analysis of Cohort Studies
Transplant recipients have a raised risk of melanoma but the relative magnitude is uncertain. We undertook a systematic review by searching major databases for relevant publications to June 2014. Cohort studies quantifying the association between transplantation and melanoma were included and data were pooled using the weighted average method. Among 20 eligible studies the pooled relative risk (pRR) of melanoma was 2.71 (95% confidence interval (CI), 2.23–3.30) with significant heterogeneity (p < 0.001). There was no indication of publication bias. Sub-group analyses by study design, follow-up period, adjustment for confounding and quality score did not materially alter results. Among liver and heart transplant patients pRR for melanoma was 5.27 (95% CI 4.50–6.62), higher than the pRR of 2.54 (95% CI 2.18–2.96) among kidney transplant patients. Transplant recipients are at more than double the risk of melanoma overall compared with the general population.]]>
2015-06-09 Special