New articles from Acta Dermato-Venereologica http://www.medicaljournals.se/acta/ Acta Dermato-Venereologica is an international peer-review journal for clinical and experimental research in the field of dermatology and venereology. 95:1 2015 - A Red-violaceous Papular Lesion in a Young Girl: A Quiz http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1880
Abstract is missing (Quiz)]]>
2014-07-17 Quiz
95:1 2015 - Recurring Axillary, Abdominal and Genitofemoral Nodules and Abscesses: A Quiz http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1890
Abstract is missing (Quiz)]]>
2014-06-11 Quiz
95:1 2015 - Erratum to: "The Incidence of Melanoma is Increasing in the Susceptible Young Australian Population" http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2005
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2014-11-03 Erratum
95:1 2015 - Assessment of the Effect of Migration on Melanoma Incidence Trends in Australia Between 1982 and 2010 Among People Under 30 http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1983
Abstract is missing (Letter to the Editor)]]>
2014-10-14 Letter
95:1 2015 - Recurrent Flexural Pellagroid Dermatitis: An Unusual Variant of Irritant Contact Dermatitis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1862
Abstract is missing (Short Communication)]]>
2014-06-11 Shortcom
95:1 2015 - ItchyQoL Bands: Pilot Clinical Interpretation of Scores http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1891
Abstract is missing (Short Communication)]]>
2014-06-05 Shortcom
95:1 2015 - ITGB4-associated Junctional Epidermolysis Bullosa without Pylori Atresia but Profound Genito-urinary Involvement http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1888
Abstract is missing (Short Communication)]]>
2014-05-21 Shortcom
95:1 2015 - Punctate Palmoplantar Keratoderma Type 1: A Novel AAGAB Mutation and Efficacy of Etretinate http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1832
Abstract is missing (Short Communication)]]>
2014-04-23 Shortcom
95:1 2015 - Sirolimus-induced Inflammatory Lymphoedema of the Breast Resolved After Switching to Cyclosporine http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1889
Abstract is missing (Short Communication)]]>
2014-05-20 Shortcom
95:1 2015 - Primary Cutaneous CD4/CD8–/– TCRαβ T-cell Lymphoma http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1883
Abstract is missing (Short Communication)]]>
2014-05-28 Shortcom
95:1 2015 - Lymphomatoid Plaquosis – A CD30+ Lymphoproliferative Rash Exhibiting a Predilection for Recurrence on the Same Skin Sites http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1873
Abstract is missing (Short Communication)]]>
2014-05-14 Shortcom
95:1 2015 - Shiitake Dermatitis – Now Also in Poland http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1867
Abstract is missing (Short Communication)]]>
2014-05-14 Shortcom
95:1 2015 - Epstein-Barr Virus-associated Methotrexate-induced Accelerated Rheumatoid Nodulosis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1866
Abstract is missing (Short Communication)]]>
2014-05-07 Shortcom
95:1 2015 - Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma in a Patient with Epidermodysplasia Verruciformis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1868
Abstract is missing (Short Communication)]]>
2014-05-06 Shortcom
95:1 2015 - Multiple White Cysts on Face and Trunk of a Melanoma Patient Treated with Vemurafenib http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1869
Abstract is missing (Short Communication)]]>
2014-06-18 Shortcom
95:1 2015 - Melanocytic Naevus Shows Parallel Ridge Pattern due to the Melanin Columns Under the Ridges http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1865
Abstract is missing (Short Communication)]]>
2014-05-06 Shortcom
95:1 2015 - Anti-laminin-γ1 Pemphigoid Developed in a Case of Autosomal Recessive Congenital Ichthyosis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1875
Abstract is missing (Short Communication)]]>
2014-05-06 Shortcom
95:1 2015 - CHILD Syndrome: Effective Treatment of Ichthyosiform Naevus with Oral and Topical Ketoconazole http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1859
Abstract is missing (Short Communication)]]>
2014-04-23 Shortcom
95:1 2015 - Development of a Disease Registry for Autoimmune Bullous Diseases: Initial Analysis of the Pemphigus Vulgaris Subset http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1854
Pemphigus vulgaris (PV) is a rare, potentially life threate-ning, autoimmune blistering skin disease. The International Pemphigus and Pemphigoid Foundation (IPPF) has recently developed a disease registry with the aim to enhance our understanding of autoimmune bullous diseases with the long-term goal of acquiring information to improve patient care. Patients were recruited to the IPPF disease registry through direct mail, e-mail, advertisements, and articles in the IPPF-quarterly, -website, -Facebook webpage, and IPPF Peer Health Coaches to complete a 38-question survey. We present here the initial analysis of detailed clinical information collected on 393 PV patients. We report previously unrecognized gender differences in terms of lesion location, autoimmune comorbidity, and delay in diagnosis. The IPPF disease registry serves as a useful resource and guide for future clinical investigation.]]>
2014-05-06 Clinical
95:1 2015 - Twelve-week Treatment of Lentigo Maligna with Imiquimod Results in a High and Sustained Clearance Rate http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1861
Topical imiquimod cream is increasingly applied in the treatment of lentigo maligna (LM), in particular for large lesions where surgery may lead to disfiguring scars. Published studies suggest that more frequent and prolonged treatment with topical imiquimod is associated with
higher efficacy. In this study we prospectively treated 27 patients suffering from LM on the face with imiquimod 5% cream using an intensive treatment regimen consisting of daily applications for 12 weeks inducing skin inflammation for at least 10 weeks. Twenty-four patients completed the treatment as recommended, 23 were available for follow-up (mean 39 months). Clinical and histo-pathological clearance was observed in 20 patients after a mean of 14 weeks of treatment. Notably, histopathological examination of a skin biopsy showed clearance of the LM in all 24 patients, including those who still showed some hyperpigmentation at 4 weeks off treatment. A clinical recurrence occurred in only 1 of the 23 patients available at follow-up. These findings suggest that the efficacy of imiquimod can be improved by implementing a more intensive treatment regimen. Randomized controlled trials are needed to confirm our results and establish the role of topical imiquimod in the treatment of LM.]]>
2014-05-06 Clinical
95:1 2015 - Haemangioma Family Burden: Creation of a Specific Questionnaire http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1847
To develop and validate a specific questionnaire to assess burden on families of children with infantile haemangioma (IH): the Haemangioma Family Burden questionnaire (HFB). Items were generated from a literature review and a verbatim report from parents. Subsequently, a study was implemented at the Necker Hospital and the Pellegrin Children’s Hospital for psychometric analysis. The HFB was refined via item reduction according to inter-question correlations, consensus among experts and exploratory factor analysis. A 20-item questionnaire, grouped into 5 dimensions, was obtained. Construct validity was demonstrated and HFB showed good internal coherence (Cronbach’s α: 0.93). The HFB was significantly correlated with the mental dimension of the Short-Form-12 (r = –0.75), and the Psychological General Well-Being Index (r = –0.61). HFB scores differed significantly according to the size and localization of the IH. A validated tool for assessing the burden on families of children with IH is now available.]]>
2014-05-28 Clinical
95:1 2015 - Vorinostat for Refractory or Relapsing Epidermotropic T-cell Lymphoma: A Retrospective Cohort Study of 15 Patients http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1886
Since the approval of vorinostat for the treatment of refractory cutaneous epidermotropic T-cell lymphoma (CTCL) in 2006, very little data about this treatment have been published. The aim of this retrospective study was to assess the efficacy and safety of vorinostat in patients with CTCL treated between 2007 and 2013 in our department. Fifteen patients (median age 64 years) were included: 9 with Sézary syndrome and 6 with mycosis fungoides. They were all in progression and the median number of systemic treatments previously administered was 3 (range 1–7). With vorinostat treatment, the best response was partial remission in 5 patients (33%) and stabilization in 4 patients (27%). Six patients experienced disease progression. The mean time to response and response duration were 70 (range 31–140) and 300 days (range 157–663), respectively. The most frequent adverse events were asthenia, weight loss, nausea and anaemia. Vorinostat could be a therapeutic alternative for CTCL after treatment failure.]]>
2014-05-22 Clinical
95:1 2015 - Higher Psychological and Psychovegetative Strain in Adolescents with Atypical Pigment Naevi http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1837
An observational, exploratory, cross-sectional study was performed to assess whether the presence of atypical naevi (AN) in adolescents is associated with psychological and psychovegetative stress parameters. Fifty-one students of a secondary school in Graz, Austria, completed a defined test procedure consisting of an initial period of rest, a standardised mental stress task, another period rest and a questionnaire, the change-sensitive symptom list (ASS-SYM). Electrocardiogram and blood pressure were recorded continuously. The study population was divided in two groups: probands without AN (NAN, n = 33), and probands with at least one AN (n = 18). We found higher values for the AN group in all scales of ASS-SYM, reaching statistical significance in the dimensions “nervousness and mental tension” (p = 0.025), “psychophysiological dysregulation” (p = 0.020), burden of pain” (p = 0.023) and “general symptoms and problems” (p = 0.031). Regarding physiological parameters, the AN group showed higher vegetative strain reflected in heart rate and > heart rate varibility during the periods of rest as well as a reduced baroreceptor sensitivity. On the basis of our results, the presence of AN in adolescents seems to be associated with a higher vegetative arousal. Additionally, participants with AN complained significantly more often about stress-associated general psychological symptoms and problems.An observational, exploratory, cross-sectional study was performed to assess whether the presence of atypical naevi (AN) in adolescents is associated with psychological and psychovegetative stress parameters. Fifty-one students of a secondary school in Graz, Austria, completed a defined test procedure consisting of an initial period of rest, a standardised mental stress task, another period rest and a questionnaire, the change-sensitive symptom list (ASS-SYM). Electrocardiogram and blood pressure were recorded continuously. The study population was divided in two groups: probands without AN (NAN, n = 33), and probands with at least one AN (n = 18). We found higher values for the AN group in all scales of ASS-SYM, reaching statistical significance in the dimensions “nervousness and mental tension” (p = 0.025), “psychophysiological dysregulation” (p = 0.020), burden of pain” (p = 0.023) and “general symptoms and problems” (p = 0.031). Regarding physiological parameters, the AN group showed higher vegetative strain reflected in heart rate and > heart rate varibility during the periods of rest as well as a reduced baroreceptor sensitivity. On the basis of our results, the presence of AN in adolescents seems to be associated with a higher vegetative arousal. Additionally, participants with AN complained significantly more often about stress-associated general psychological symptoms and problems.]]>
2014-05-06 Clinical
95:1 2015 - Cutaneous Leishmaniasis in Syria: Clinical Features, Current Status and the Effects of War http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1988
Cutaneous leishmaniasis (CL) is a worldwide disease caused by an infection with the protozoan parasite Leishmania transmitted via sand flies. It is endemic in many of the poorest countries of all continents. “Aleppo boil” is one of the recognised names given to this disease in the medical literature. Although CL used to be well-controlled and well-documented in Syria, its incidence has dramatically increased since the beginning of the war; however, there is lack of documentation. Here, we present the past and current epidemiological situation of the disease in Syria. We also draw attention to gross and highly unusual clinical variants of CL presented to the Department of Dermatology in Aleppo covering the important differential clinical diagnoses, since this disease is already known to mimic other conditions. Diagnostic procedures and treatment as well as prevention are summarised. Due to the increased ability to travel, and especially the flight of Syrians to neighbouring countries, as well as to Europe, CL may become a new threat in formerly unaffected regions. Through this account, we hope to give weight to the aspiration that CL does not remain a neglected and often clinically overlooked tropical dermatosis]]>
2014-10-28 Clinical
95:1 2015 - Etanercept Reduces Symptoms and Severity of Psoriasis After Cessation of Cyclosporine Therapy: Results of the SCORE Study http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1845
Cyclosporine is an established therapy for psoriasis that provides rapid relief of symptoms but has long-term toxic side effects. The objective of this study was to demonstrate the efficacy of etanercept as replacement therapy for cyclosporine in patients with moderate-to-severe plaque psoriasis. Patients with plaque psoriasis were given cyclosporine 5 mg/kg/day until achievement of PASI50 at which point cyclosporine was tapered to 0 over 6 weeks. At week 6, patients were randomised (1:1) to receive etanercept (50 mg/week) or placebo for an additional 24 weeks. Patients in the etanercept group (n = 58) experienced a reduction of –1.1 in mean PASI score (p = 0.233 vs. cyclosporine) at week 30; patients in the placebo group (n = 62) had mean PASI increase of 3.7 (p < 0.001 vs. cyclosporine). The incidence of patients reporting any adverse events was not significant between groups (77% etanercept, 74% placebo; p = 0.675). Etanercept demonstrated higher efficacy and good tolerability as replacement therapy for cyclosporine in plaque psoriasis.]]>
2014-06-03 Clinical
95:1 2015 - A Web-based, Educational, Quality-of-life Intervention for Patients with a Chronic Skin Disease: Feasibility and Acceptance in Routine Dermatological Practice http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1872
Chronic skin diseases have a negative impact on patients’ health-related quality of life (HRQoL). Patient education might contribute to HRQoL improvement. We developed a web-based, educational, HRQoL intervention for patients with a chronic skin disease. We aimed to assess 1) the feasibility of implementing the intervention in routine dermatological practice and patients’ daily life, and 2) the acceptance of the intervention by health care providers and patients. Additionally, we aimed to create a patient user profile. We conducted an observational pilot study at 6 dermatological centres, including 105 outpatients. Implementation in routine practice was feasible and acceptable to health care providers. However, implementation in patients’ daily life was found not to be entirely feasible. Perceived relevance by patients was low, though patients rated the intervention as convenient and attractive. No univocal user profile was found. Suggestions for improvements of the intervention, e.g. tailoring and adding blended learning components, are discussed.]]>
2014-05-27 Investigative
95:1 2015 - Monitoring Treatment of Field Cancerisation with 3% Diclofenac Sodium 2.5% Hyaluronic Acid by Reflectance Confocal Microscopy: A Histologic Correlation http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1860
Visual inspection may fail to accurately evaluate field cancerisation (subclinical actinic keratoses [AKs]). We aimed to describe field cancerisation by confocal reflectance microscopy and changes induced by the application of 3% diclofenac sodium gel in 2.5% hyaluronic acid. Fourteen male patients, > 50 years old, with AKs on the bald scalp were included. Clinical examination, confocal microscopy and histological study of clinically visible lesions and “normal appearing” adjacent skin before and after treatment was completed. Reflectance confocal microscopy showed a decrease in scaling (p = 0.001) and atypia of the honeycomb pattern (p = 0.001) at 2 weeks of treatment. Changes in parakeratosis, inflammation and dermal collagen remodelling were also observed. Histology correlated with confocal features in AK and subclinical AK. Reflectance confocal microscopy was useful in the evaluation of field cancerisation and monitoring of treatment response. A rapid improvement in epidermal atypia was observed.]]>
2014-07-21 Investigative
95:1 2015 - Chronically Sun-damaged Melanomas Express Low Levels of Nuclear Glutathione-S-transferase-π: An Epidemiological and Clinicopathological Study in Italy http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1821
The detoxifying enzyme glutathione–s–transferase pi (GST–π) is present in keratinocytes and melanocytes and exerts a protective role against tumour progression. Melanomas close to melanocytic naevus remnants occur less frequently on sun-exposed areas, whereas solar dermal elastosis, hallmark of chronic sun-damage, characterise melanomas on sun-exposed skin. We evaluated the expression of GST-π in 113 melanomas associated to melanocytic naevus remnants or to solar dermal elastosis, classified according to clinical characteristics, history of sun exposure, histological subtypes and AJCC staging. Chronically sun-damaged melanomas, identified by moderate–severe solar dermal elastosis, showed a lower nuclear GST-π expression and a higher thickness than those related to melanocytic naevus remnants (p < 0.03). Multivariate logistic regression analysis demonstrated that male gender and chronic sun-exposure are independent risk factors significantly associated to melanomas localised on the trunk (OR = 3.36, 95% CI: 1.31–8.65; OR = 5.97, 95% CI: 1.71–20.87). If confirmed on a larger series, lower expression of nuclear GST-π in melanoma cells could represent a possible marker of chronically sun-damaged melanoma pathogenesis.]]>
2014-05-28 Investigative
95:1 2015 - Concordance and Time Estimation of Store-and-forward Mobile Teledermatology Compared to Classical Face-to-face Consultation http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1876
Smartphones have overcome the limitations of image quality seen in older devices and opened a new field of telemedicine called “mobile teledermatology”. Technological advances and the need to reduce health service costs will strongly promote the development of telemedicine. For this reason, we evaluated the concordance between store-and-forward mobile teledermatology and the classical face-to-face dermatological visit. We also measured the time taken to submit a teleconsultation using a smartphone. Before conventional face-to-face visit, a final-year resident of the three-year course for general practitioners collected medical history, took digital images of skin diseases with a smartphone and, measuring the time required to complete this operation, transmitted them to an expert teledermatologist. In 391 patients we obtained a concordance between face-to-face and store-and-forward diagnosis of 91.05% (Cohen κ coefficient = 0.906). On average only few minutes needs to be added to a normal visit to transmit the cases to an expert teledermatologist.]]>
2014-05-13 Investigative
95:1 2015 - Methylisothiazolinone Contact Allergy is Rising to Alarming Heights Also in Southern Sweden http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1844
The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in most baseline series since at least 20 years. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative in occupational and household products, and cosmetics since less than 10 years. MCI/MI tested at 100 ppm fails to detect a significant percentage of contact-allergic reactions to MI. Our aim was to investigate whether a separate test preparation with MI picks up additional cases of contact allergy to MI not detected with MCI/MI 200 ppm. MI was inserted into the baseline series of the Malmö clinic in 2003 starting at 475 ppm, then 900 ppm, then 1,000 ppm, 1,500 ppm and finally 2,000 ppm. In 5,881 consecutively tested dermatitis patients the contact allergy rate for MI varied between 0.5 and 6.5%, with a marked increase in recent years. The contact allergy rate to MI 2,000 ppm alone, not traced by MCI/MI 200 ppm, varied between 0 and 1.9 %. In conclusion, due to the increase of contact allergy to MI not traced by MCI/MI 200 ppm, MI in water at 2,000 ppm should be tested in a baseline series. Independent of patch test technique a dose of 60 µg/cm should not be exceeded to avoid adverse reactions and particularly patch test sensitisation.]]>
2014-05-06 Investigative
95:1 2015 - Gender Differences in Itch and Pain-related Sensations Provoked by Histamine, Cowhage and Capsaicin http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1894
Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects. Sensory qualities were assessed by questionnaire; intensities and time courses of the “itching” and “burning” sensation were measured alternately, but continuously on a VAS. In addition, axon reflexes were assessed. Only histamine and capsaicin produced a clear axon reflex flare (histamine > capsaicin, male = female). The 3 types of spicules caused mixed burning and itching sensations with different time courses. In the beginning burning prevailed, in the following minutes histamine induced mostly itching, capsaicin predominantly burning, cowhage both sensory components equally. Female subjects experienced more pain-related sensations (questionnaire), and their ratings leaned more toward burning than those of males. These findings indicate that the mixed itching and burning sensations are differentially processed by both genders. No indications were found for gender specific differential processing in the primary afferents as reflected by nearly identical flare responses.]]>
2014-06-05 Investigative
95:1 2015 - Increased Expression of Three Types of Transient Receptor Potential Channels (TRPA1, TRPV4 and TRPV3) in Burn Scars with Post-burn Pruritus http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1858
Post-burn pruritus is a common distressing consequence of burn wounds. Empirical treatment often fails to have a satisfactory outcome on post-burn pruritus, as the mechanism of post-burn pruritus has not been fully elucidated. The aim of this study was to evaluate the manifestation of transient receptor potential (TRP) channels in post-burn pruritus. Fifty-one burn patients with (n=33) or without (n=18) pruritus were investigated, including skin biopsies. Not unexpectedly, the scarred body area was larger in the former group. In immunohistochemistry, TPRV3 was significantly elevated in the epidermis of burn scars with pruritus. Furthermore, real time- PCR showed that mRNA of TRPA1 and TRPV4 was increased in itching burn scars. Staining for substance P and CGRP did not differ between the 2 grouped, but the former neuropeptide was increased in burn scars. These results may help determine a specific therapeutic approach for post-burn pruritus.]]>
2014-06-04 Investigative
95:1 2015 - Evidence-based Danish Guidelines for the Treatment of Malassezia-related Skin Diseases http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1825
Internationally approved guidelines for the diagnosis and management of Malassezia-related skin diseases are lacking. Therefore, a panel of experts consisting of dermatologists and a microbiologist under the auspices of the Danish Society of Dermatology undertook a data review and compiled guidelines for the diagnostic procedures and management of pityriasis versicolor, seborrhoeic dermatitis and Malassezia folliculitis. Main recommendations in most cases of pityriasis versicolor and seborrhoeic dermatitis include topical treatment which has been shown to be sufficient. As first choice, treatment should be based on topical antifungal medication. A short course of topical corticosteroid or topical calcineurin inhibitors has an anti-inflammatory effect in seborrhoeic dermatitis. Systemic antifungal therapy may be indicated for widespread lesions or lesions refractory to topical treatment. Maintenance therapy is often necessary to prevent relapses. In the treatment of Malassezia folliculitis systemic antifungal treatment is probably more effective than topical treatment but a combination may be favourable.]]>
2014-04-23 Special
95:1 2015 - The Potential Role of Impaired Notch Signalling in Atopic Dermatitis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1898
This review presents recent evidence of impaired Notch signalling in atopic dermatitis (AD), which is proposed to represent the “a-topic” defect linking both epidermal and immunological barrier dysfunctions in AD. AD epidermis exhibits a marked deficiency of Notch receptors. Mouse models with genetically suppressed Notch signalling exhibit dry skin, signs of scratching, skin barrier abnormalities, increased transepidermal water loss and TH2 cell-mediated immunological changes closely resembling human AD. Notch signals are critically involved in the differentiation of regulatory T cells, in the feedback inhibition of activated innate immunity, in late epidermal differentiation associated with filaggrin- and stratum corneum barrier lipid processing. Most importantly, Notch deficiency induces keratinocyte-mediated release of thymic stromal lymphopoietin (TSLP). TSLP promotes TH2 cell-driven immune responses associated with enhanced production of interleukin (IL)-4 and IL-31. Both TSLP and IL-31 stimulate sensory cutaneous neurons involved in the induction of itch. Notably, Notch1 is a repressor of activator protein-1 (AP-1), which is upregulated in AD epidermis. Without Notch-mediated suppression of AP-1 this transcription factor promotes excess expression of TH2 cell-related cytokines. Impaired Notch signalling negatively affects the homeostasis of aquaporin 3 and of the tight junction component claudin-1, thus explains disturbed skin barrier function with increased transepidermal water loss and Staphylococcus aureus colonisation as well as increased cutaneous susceptibility for viral infections. Thus, accumulating evidence links deficient Notch signalling to key pathological features of AD.]]>
2014-08-12 Review
95:1 2015 - Cutaneous Leishmaniasis and Human Conflict http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1994
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2014-11-03 Commentary
94:6 2014 - Index of Volume 94, 2014 http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1969
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2014-10-15 Index
94:6 2014 - Periungual Swelling and Nail Dystrophy in a Healthy Male: A Quiz http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1798
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2014-01-23 Quiz
94:6 2014 - Arc-shaped Plaque on the Forehead: A Quiz http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1839
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2014-03-25 Quiz
94:6 2014 - Onychotillomania in the Course of Depression: A Case Report http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1805
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2014-01-29 Shortcom
94:6 2014 - Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1846
Abstract is missing (Short Communication)]]>
2014-04-08 Shortcom