New articles from Acta Dermato-Venereologica Acta Dermato-Venereologica is an international peer-review journal for clinical and experimental research in the field of dermatology and venereology. 95:7 2015 - Abstracts from the 8th World Congress on Itch (WCI) in Nara on September 27–29, 2015
2015-08-25 Abstractbook
95:7 2015 - What are the “True” Pathogenic Anti-desmoglein Antibodies?
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2015-05-06 Letter
95:7 2015 - Smartphone Teledermoscopy Referrals: Comment on the paper by Börve et al.
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2015-05-07 Letter
95:7 2015 - Successful Methotrexate Treatment of Oesophageal Pemphigus Vulgaris in an Immunosuppressed Patient with Crohn’s Disease
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2015-03-17 Shortcom
95:7 2015 - Oral Tacrolimus Treatment of Pruritus in Prurigo Nodularis
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2015-04-29 Shortcom
95:7 2015 - Successful Treatment of Refractory Neuropathic Pruritus with Capsaicin 8% Patch: A Bicentric Retrospective Study with Long-term Follow-up
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2015-03-16 Shortcom
95:7 2015 - Social Anxiety Disorder and Agoraphobia in Dermatology Patients; Two Cases and a Review of the Literature
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2015-03-17 Shortcom
95:7 2015 - Congenital and Disseminated Pyogenic Granuloma-like Vascular Lesions
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2015-04-07 Shortcom
95:7 2015 - Lamellar Ichthyosis Caused by a Previously Unreported Homozygous ALOXE3 Mutation in East Asia
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2015-04-08 Shortcom
95:7 2015 - Deep Cutaneous Infection with Microsphaeropsis arundinis: Report of two Japanese Cases
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2015-03-23 Shortcom
95:7 2015 - Drug Eruption Following High-calorie Infusion: A Possible Systemic Type IV Allergic Reaction to Sulphites
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2015-03-26 Shortcom
95:7 2015 - Absence of Full-length Neurokinin-1 Receptor Protein Expression by Cutaneous T Cells: Implications for Substance P-mediated Signaling in Mycosis Fungoides
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2015-04-09 Shortcom
95:7 2015 - Junctional Epidermolysis Bullosa with LAMB3 Splice-site Mutations
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2015-04-09 Shortcom
95:7 2015 - Safety and Efficacy of Human Fibroblast Lysate Cream for Vulvar Lichen Sclerosus: A Randomized Placebo-controlled Trial
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2015-03-05 Shortcom
95:7 2015 - Preoperative Management of Antithrombotic Medication in Mohs Micrographic Surgery
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2015-04-09 Shortcom
95:7 2015 - Elevated Serum Levels of BP180 Antibodies in the First Trimester of Pregnancy Precede Gestational Pemphigoid and Remain Elevated for a Long Time After Remission of the Disease
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2015-03-18 Shortcom
95:7 2015 - Treponema pallidum Haemagglutination Assay Serum Titres as a Predictor of Cerebrospinal Fluid Abnormalities in Patients with Syphilis
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2015-03-09 Shortcom
95:7 2015 - Sentinel Node Status and Immunosuppression: Recurrence Factors in Localized Merkel Cell Carcinoma
The prognostic value of the sentinel lymph node in Merkel cell carcinoma (MCC) has been examined previously in heterogeneous retrospective studies. The current retrospective study included a homogeneous population of patients with a localized MCC, all staged with sentinel lymph node biopsy. Factors associated with 3-year progression-free survival were analysed using logistic regression. The sentinel lymph node was positive in 32% of patients. The recurrence rate was 26.9%. In first analyses (n = 108), gender (p = 0.0115) and the presence of immunosuppression (p = 0.0494) were the only significant independent factors. In further analyses (n = 80), excluding patients treated with regional radiotherapy, sentinel lymph node status was the only significant prognostic factor (p = 0.0281). Immunosuppression and positive sentinel lymph node are associated with a worse prognosis in patients with MCC. Nodal irradiation impacts on the prognostic value of the sentinel lymph node status.]]>
2015-04-14 Clinical
95:7 2015 - Actinic Keratoses, Actinic Field Change and Associations with Squamous Cell Carcinoma in Renal Transplant Recipients in Manchester, UK
While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals in Manchester, UK, counting AKs and recording field change presence by body site and SCCs arising during the study period. Of the participants 130 (29%) had AKs at examination. In 60 (13%) RTR patients with AKs but no field change, 4 (7%) developed SCCs, compared with 15 (21%) of the 70 (15%) with AKs and field change. SCCs developed directly within field change areas in 11/15 (73%) RTRs. This study confirms that RTRs with widespread confluent actinic skin damage are at very high risk of SCC and should be monitored closely. ]]>
2015-04-08 Clinical
95:7 2015 - A Case of Subepidermal Blistering Disease with Autoantibodies to Multiple Laminin Subunits who Developed Later Autoantibodies to Alpha-5 Chain of Type IV Collagen Associated with Membranous Glomerulonephropathy
We report a 68-year-old Japanese female patient with subepidermal blistering disease with autoantibodies to multiple laminins, who subsequently developed membranous glomerulonephropathy. At skin disease stage, immunofluorescence demonstrated IgG anti-basement membrane zone antibodies reactive with dermal side of NaCl-split skin. Immunoblotting of human dermal extract, purified laminin-332, hemidesmosome-rich fraction and laminin-521 trimer recombinant protein (RP) detected laminin γ-1 and α-3 and γ-2 subunits of laminin-332. Three years after skin lesions disappeared, nephrotic symptoms developed. Antibodies to α-3 chain of type IV collagen (COL4A3) were negative, thus excluding the diagnosis of Goodpasture syndrome. All anti-laminin antibodies disappeared. Additional IB and ELISA studies of RPs of various COL4 chains revealed reactivity with COL4A5, but not with COL4A6 or COL4A3. Although diagnosis of anti-laminin γ-1 (p200) pemphigoid or anti-laminin-332-type mucous membrane pemphigoid could not be made, this case was similar to previous cases with autoantibodies to COL4A5 and/or COL4A6.]]>
2015-04-13 Investigative
95:7 2015 - Retrospective Evaluation of Conservative Treatment for 140 Ingrown Toenails with a Novel Taping Procedure
The aim of this study is retrospectively to review the efficacy of a taping procedure for treating ingrown toe­nails or for supporting other conservative treatments of ingrown toenails. A total of 140 ingrown toenails treated at the Dermatology Clinic in Tohoku University Hospital were retrospectively reviewed for demographic characteristics, association with granulation tissue or infection, treatment modalities and their outcomes, and classified according the treatment modalities. All the ingrown toe­nails were treated with a novel taping procedure, “slit tape-strap procedure” alone or in conjunction with other conservative treatments. The mean?±?SD duration until pain relief and until cure of the ingrown toenail were 4.8?±?4.7 days, range 0–24 and 21.0?±?11.2 weeks, range 4–56, respectively. All of the treatments were all effective, although 18 cases recurred after treatment. The “slit tape-strap procedure” is effective in treating ingrown toenails, either as a monotherapy or as a supportive therapy for other conservative treatments.]]>
2015-03-17 Clinical
95:7 2015 - Prevalence of Chronic Itch and Associated Factors in Haemodialysis Patients: A Representative Cross-sectional Study
Chronic itch is a common symptom in haemodialysis (HD) patients, which is often underestimated. The aim of this cross-sectional study was to investigate the prevalence and factors associated with chronic itch in HD patients. A total of 860 HD patients from a randomly selected cluster-sample of patients attending dialysis units in Germany were included. The patients’ mean?±?SD age was 67.2?±?13.5 years, 57.2% were male. The point prevalence of chronic itch was 25.2% (95% CI 22.4–28.1), 12-month prevalence was 27.2% (95% CI 24.1–30.3) and lifetime prevalence was 35.2% (95% CI 31.9–38.3). Chronic itch was significantly less prevalent in patients with secondary glomerulonephritis as primary renal disease. A history of dry skin, eczema, and age
2015-04-10 Clinical
95:7 2015 - Increased Cause-specific Mortality in Patients with Mild and Severe Psoriasis: A Population-based Swedish Register Study
Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based on data from Swedish administrative registers and compared the risk of death in 39,074 patients with psoriasis with 154,775 sex-, age- and residency-matched referents using Cox proportional hazards models. In patients with mild and severe psoriasis, the strongest associations were observed for deaths due to kidney disease (hazard ratio [HR]=2.20, p < 0.01) and liver disease (HR = 4.26, p < 0.001), respectively. Whilst cardiovascular disease was the main driver of excess mortality in absolute terms, the risks for other causes of death were also substantially elevated in patients with psoriasis compared with matched referents.]]>
2015-04-28 Investigative
95:7 2015 - Changes in Body-site Distribution of Common Melanocytic Naevi Among 7-year-old Swedish Children Between 2002 and 2007
An observational population-based study conducted among 2 sets of 7-year-old children in Sweden in 2002 and 2007 revealed evidence of improved sun protection, also reflected in a significant reduction in the total number of melanocytic naevi. Based on these data-sets, the aim of the current study was to determine whether the overall reduction in naevi had impacted differently on body sites based on their main pattern of sun exposure. In 2002, median naevi counts/m2 were highest on intermittently sun-exposed sites: 13.8 (95% CI 8.0–22.7) compared with chronically sun-exposed sites: 11.0 (95% CI 0.0–20.5). In 2007, median naevi counts/m2 on intermittently sun-exposed body sites were significantly lower: 8.7 (95% CI 4.7–15.2), p < 0.0001, while on chronically exposed sites median naevi counts/m2 were unaltered: 10.3 (95% CI 0.0–14.4), p = 0.9313. Changes were most evident among boys. Future research can evaluate whether this shift in naevi distribution in Swedish children translates into a reduction in cutaneous melanomas on intermittently sun-exposed body sites.]]>
2015-04-08 Investigative
95:7 2015 - A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde
The thermoreceptive transient receptor potential ankyrin 1 (TRPA1) is important in the transmission of itch, and its agonist trans-cinnamaldehyde has occasionally been reported to be a pruritogen in humans. However, no studies have accurately quantified the capabilities of trans-cinnamaldehyde to induce itch and related dysesthetic sensations. The present study examined alterations in somatosensory and vasomotor parameters in response to topical trans-cinnamaldehyde 5% and vehicle (ethanol) in 24 healthy subjects. During the study the following parameters were recorded: itch area and intensity, hyperknesis, alloknesis, neurogenic flare, skin blood flow and temperature. Trans-cinnamaldehyde evoked moderate itch sensation, flare, hyperknesis and alloknesis (p < 0.001). Blood flow and skin temperature were elevated in the area of trans-cinnamaldehyde application (p < 0.001). Significant positive correlations were found between blood flow and skin temperature, itch area and blood flow, and itch area and skin temperature. Topical trans-cinnamaldehyde proved feasible as a human itch model with applicability in studying itch mechanisms or anti-pruritic drug profiling. ]]>
2015-04-14 Investigative
95:7 2015 - Melanoma Growth and Progression After Ultraviolet A Irradiation: Impact of Lysosomal Exocytosis and Cathepsin Proteases
Ultraviolet (UV) irradiation is a risk factor for development of malignant melanoma. UVA-induced lysosomal exocytosis and subsequent cell growth enhancement was studied in malignant melanoma cell lines and human skin melanocytes. UVA irradiation caused plasma membrane damage that was rapidly repaired by calcium-dependent lysosomal exocytosis. Lysosomal content was released into the culture medium directly after irradiation and such conditioned media stimulated the growth of non-irradiated cell cultures. By comparing melanocytes and melanoma cells, it was found that only the melanoma cells spontaneously secreted cathepsins into the surrounding medium. Melanoma cells from a primary tumour showed pronounced invasion ability, which was prevented by addition of inhibitors of cathepsins B, D and L. Proliferation was reduced by cathepsin L inhibition in all melanoma cell lines, but did not affect melano-cyte growth. In conclusion, UVA-induced release of cathepsins outside cells may be an important factor that promotes melanoma growth and progression.]]>
2015-03-17 Investigative
95:7 2015 - Ultra-pure Soft Water Ameliorates Atopic Skin Disease by Preventing Metallic Soap Deposition in NC/Tnd Mice and Reduces Skin Dryness in Humans
Mineral ions in tap water react with fatty acids in soap, leading to the formation of insoluble precipitate (metallic soap) on skin during washing. We hypothesised that metallic soap might negatively alter skin conditions. Application of metallic soap onto the skin of NC/Tnd mice with allergic dermatitis further induced inflammation with elevation of plasma immunoglobulin E and proinflammatory cytokine expression. Pruritus and dryness were ameliorated when the back of mice was washed with soap in Ca2+- and Mg2+-free ultra-pure soft water (UPSW). Washing in UPSW, but not tap water, also protected the skin of healthy volunteers from the soap deposition. Furthermore, 4 weeks of showering with UPSW reduced dryness and pruritus of human subjects with dry skin. Washing with UPSW may be therapeutically beneficial in patients with skin troubles.]]>
2015-03-16 Investigative
95:7 2015 - Reduced Expression of Dermcidin, a Peptide Active Against Propionibacterium acnes, in Sweat of Patients with Acne Vulgaris
Dermcidin (DCD), an antimicrobial peptide with a broad spectrum of activity against bacteria such as Propionibacterum acnes, is expressed constitutively in sweat in the absence of stimulation due to injury or inflammation. The aim of this study was to determine the relationship between DCD expression and acne vulgaris associated with P. acnes. The antimicrobial activity of recombinant full-length DCD (50 μg/ml) was 97% against Escherichia coli and 100% against Staphylococcus aureus. Antimicrobial activity against P. acnes ranged from 68% at 50 μg/ml DCD to 83% at 270 μg/ml DCD. DCD concentration in sweat from patients with acne vulgaris (median 9.8 μg/ml, range 6.9–95.3 μg/ml) was significantly lower than in healthy subjects (median 136.7 μg/ml, range 45.4–201.6 μg/ml) (p = 0.001). DCD demonstrated concentration-dependent, but partial, microbicidal activity against P. acnes. These results suggest that reduced DCD concentration in sweat in patients with inflammatory acne may permit proliferation of P. acnes in pilosebaceous units, resulting in progression of inflammatory acne.]]>
2015-03-18 Investigative
95:7 2015 - Intralesional 5-Fluorouracil in Keloid Treatment: A Systematic Review
In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms “keloid” and “5-FU”, together with all synonyms of these terms. Two reviewers selected original research reports using 5-FU alone or combined with a maximum of 2 other therapies. Eighteen papers were found that reported either on intralesional 5-FU alone, or on 5-FU combined with triamcinolone acetonide (TAC:5-FU) or excision, including 482 patients. 5-FU treatment was effective in 45–96% of patients, but only TAC:5-FU may perform better than TAC alone. Due to a poor level of evidence, further research should establish the superiority of repeated intralesional TAC:5-FU injections over TAC alone with several doses and injection schedules. ]]>
2015-04-15 Special
95:7 2015 - Human Surrogate Models of Histaminergic and Non-histaminergic Itch
Within the last decade understanding of the mechanistic basis of itch has improved significantly, resulting in the development of several human surrogate models of itch and related dysesthetic states. Well-characterized somatosensory models are useful in basic studies in healthy volunteers, in clinical studies for diagnostic and segmentation purposes, and in pharmacological studies to evaluate the antipruritic efficacy of existing and novel compounds. This review outlines recently introduced histamine-independent human models of itch, their mechanisms, their ability to induce clinically relevant phenomena, such as alloknesis, and the results obtained through their use. The article also introduces recent advances in the understanding of itch and provides an overview of the methods to assess experimentally-induced itch and associated manifestations. Major improvements are warranted in the treatment of chronic pruritus, and reliable human surrogate models are a valuable tool in achieving them, both for basic researchers and for clinicians]]>
2015-06-08 Review
95:6 2015 - ERRATUM
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2015-06-23 Erratum
95:6 2015 - Linear Skin-coloured Papules on Scrotum: A Quiz
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2015-03-02 Quiz
95:6 2015 - Yellow Changes of the Skin: A Quiz
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2015-03-05 Quiz
95:6 2015 - Pruritic Papules Following Lumbar Corset Use: A Quiz
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2015-03-02 Quiz
95:6 2015 - Bilateral Sporotrichoid Cutaneous Infection by Mycobacterium haemophilum in a Chinese Patient with Systemic Lupus Erythematosus
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2015-03-04 Shortcom
95:6 2015 - Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide
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2015-03-03 Shortcom
95:6 2015 - Annular Elastolytic Giant Cell Granuloma Successfully Treated with Minocycline Hydrochloride
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2015-02-27 Shortcom
95:6 2015 - A Case of Felty’s Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma
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2015-02-27 Shortcom
95:6 2015 - Skin Abnormalities in CHILD Syndrome Successfully Treated with Pathogenesis-based Therapy
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2015-02-24 Shortcom
95:6 2015 - Screening for Neuropathic Pain, Anxiety and Other Associated Chronic Pain Conditions in Vulvodynia: A Pilot Study
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2015-02-13 Shortcom