An international peer-reviewed journal for clinical and experimental research in the field of dermatology and venereology.
Published by the Non-Profit Organization Society for Publication of Acta Dermato-Venereologica
The official Journal of:
European Society for Dermatology and Psychiatry
Affiliated with:
International Forum for the Study of Itch
ISI Impact Factor 2018: 3.531 H Index: 75
This registry study from DERMBIO demonstrate weak-to-moderate correlations between PASI and DLQI during a 5-year period and between changes in PASI and DLQI in patients treated with biologics or apremilast. Of all the questions of the DLQI, the first question on “Symptoms and feelings” was the one contributing most to the overall DLQI and this increased over time. The results of this study show that some of the questions of the DLQI might be redundant and additional measures to capture subjective symptoms might be beneficial in future studies and daily practice.
We experienced a patient with psoriatic arthritis who developed atopic dermatitis-like eruptions caused by administration of two different types of biologics, infliximab and ixekizumab. Skin biopsy revealed epidermal spongiosis and lymphocyte perivascular infiltration in upper dermis. It is suggested that atopic dermatitis-like eruptions are not a skin disorder specific to a drug but might occur in patients with psoriasis treated with any biologics. A possible reason for the development of atopic dermatitis-like eruptions is transition from Th1 to Th2 dominance by biologics.
