ISI Impact Factor 2017: 3.127
An international peer-reviewed journal for clinical and experimental research in the field of dermatology and venereology.
Published by the Non-Profit Organization Society for Publication of Acta Dermato-Venereologica
The official Journal of:
European Society for Dermatology and Psychiatry
Affiliated with:
International Forum for the Study of Itch
Melanogenesis or excessive production of melanin in the skin causes hyperpigmentation disorders - melasma, senile lentigines and freckles. Although skin hyperpigmentation is not a serious health concern, it can profoundly impact individual’s appearance and cause cosmetic disfigurement. Here, we summarize the molecular mechanism of melanogenesis and update about inhibitors currently being applied or investigated to manage hyperpigmentation.
Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signall ...
