Legionnaires' Disease Associated with Macular Rash: Two Cases
Leonardo Calza, Elisabetta Briganti, Stefania Casolari, Roberto Manfredi, Francesco Chiodo, Tiziano Zauli
Legionnaires' disease is an acute bacterial infection, generally sustained by Legionella pneumophila , which involves primarily the lower respiratory tract, although it is often associated with multi-systemic extrapulmonary manifestations. Afflicted patients may sometimes have gastrointestinal symptoms, liver function abnormalities, renal failure or central nervous system complications, while cutaneous manifestations are very uncommon and may include erythematous, maculopapular or petechial skin lesions. Pathogenesis of skin involvement in the setting of Legionnaires' disease is still uncertain, but may involve toxic or immunological mechanisms. Two exceptional cases of Legionella pneumonia complicated by diffuse, macular rash in two adult women are described, in association with severe peripheral polyneuropathy and flaccid quadriplegia in one case.