Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons
Sarah Ehling, Tomoki Fukuyama, Mei-Chuan Ko, Thierry Olivry, Wolfgang Bäumer
Neuromedin B is expressed in nociceptive and itch-sensitive dorsal root ganglia neurons, but its peripheral pruritogenic potential is not well described. The potential of neuromedin B as a pruritogen and pro-inflammatory peptide in the skin was tested in vivo in an acute model in mice and monkeys as well as an allergic dermatitis model in mice. To identify the underlying mechanisms in vitro real time PCR analysis for neuromedin B and its receptor expression in murine mast cells and dorsal root ganglia as well as functional calcium imaging in the ganglia was applied. Neuromedin B induces itch when injected intradermally, and the peripheral signal is likely transmitted through the activation of dorsal root ganglia. Thus, neuromedin B could be an interesting new therapeutic target for peripheral processing of itch at the level of sensory neurons.
Neuromedin B is expressed in neurons involved in itch but its peripheral pruritogenic potential is not well described. Neuromedin B induces itch in mice and monkeys when injected into the skin. Most likely this itch signal is transmitted through the activation of peripheral neurons. So far the pathogenesis of pruritus is quite complex. It remains important to investigate and subsequently develop novel mechanism-based strategies to treat pruritus and possibly provide a locus for pharmacological control of pruritus. Thus, Neuromedin B could be an interesting new therapeutic target for peripheral processing of itch at the level of sensory neurons.