Psoriasis and Treatment: Past, Present and Future Aspects
Claire Reid, Christopher E.M. Griffiths
The management of psoriasis has evolved considerably over the past 100 years. This has occurred in parallel with our understanding of the pathogenesis of this common, complex and enigmatic disease. It should be celebrated as an outstanding example of successful translational research. With precise targeting of immune pathways for the treatment of psoriasis with new biologics and small molecules has come the realisation that the most effective approach to patient management is a holistic one which encompasses the biopsychosocial nature of the disease. This involves a stratified medicine approach to identifying the best drug for an individual allied to patient education, screening for comorbidity, and regular review as both the clinical presentation and the patient’s needs will change over time. Although there is not yet a cure for psoriasis – the whole person, systems approach to patient management, that is in part dependent on early intervention, should help to ensure an optimal outcome.
Psoriasis is a common and disfiguring chronic skin condition. Over the past 100 years, our understanding of the disease has improved and as a direct result, more effective therapies have been developed. In addition to the cutaneous manifestations, it is associated with an increased risk of psoriatic arthritis, depression and cardiovascular disease. The best approach to care is an individualised one which focuses on improving the physical symptoms of the rash while proactively screening for and treating any associated comorbidities to minimise the impact of the disease and empower patients to live well.