Cost-effectiveness of Emollients in the Prevention of Relapse among French Patients with Atopic Dermatitis
Elise Cabout, Sébastien Eymere, Robert Launois, Sophie Séité, Véronique Delvigne, Charles Taïeb, Ziad Reguai
Atopic dermatitis affects up to 20% of children and quite frequently persists in adulthood. Follow-up, treatment, and prevention of relapses have an impact on healthcare spending. The aim of this study was to assess the cost-effectiveness of different emollients prescribed for patients with atopic dermatitis in France. A 3-health state Markov model was designed, using French data for resource utilization, price and transition probabilities. The effects of the use of 5 different emollients (A, B, C, D, E) or no emollient were compared. The selected outcome was time (years) without flare-up (YWFU). The 5-year cost for emollient A is 1,575.64€, and the effectiveness is 3.89 YWFU. Strategy A is the most effective. Compared with treatment E, which was the least expensive emollient, A is more expensive (+481.84€) and more effective (0.082 YWFU). The incremental cost-effectiveness ratio is 5,877.48€/YWFU. In conclusion, treating atopic dermatitis with emollients is a cost-effective strategy.
Emollients are recommended as treatment for atopic dermatitis. The model used in this study aims to assess the cost-effectiveness of different emollients in the French setting. The effectiveness of the treatment was evaluated by measuring the relapse-free period. When accounting for consultation, hospitalization, and medication costs, as well as productivity losses, the use of emollients was found to be cost-effective compared with no emollient. The strategy of using of no emollients was worse based on 2 of the 4 selected comparators: it is both more expensive and less effective. Dominant cost-effective strategies should be preferred by physicians.