Content » Vol 63, Issue 1

Assay of comedolytic activity in acne patients

Mills OH Jr, Kligman AM.
DOI: 10.2340/00015555636871


Comedolytic activity was assessed in acne patients by determining the reduction in facial microcomedones using the cyanoacrylate follicular biopsy technique. Microcomedones were counted in five-em squares after 8 to 12 weeks of treatment. Only salicylic acid and tretinoin among seven conventional anti-acne medications were found to possess comedolytic activity. The latter was the more effective.


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