Content » Vol 64, Issue 1

The influence of the opiate antagonist naloxone on experimental pruritus

Fjellner B, Hägermark O.
DOI: 10.2340/00015555647375


The antipruritic effect of naloxone hydrochloride was evaluated in a double-blind, cross-over design. Systemic pretreatment with the opiate antagonist did not interfere with the cutaneous itch and flare responses evoked by morphine or histamine, nor did it inhibit the morphine-produced potentiation of the histamine-elicited skin reactions.


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