Content » Vol 66, Issue 3

Calmodulin levels in psoriasis: the effect of treatment

Tucker WF, MacNeil S, Dawson RA, Tomlinson S, Bleehen SS.
DOI: 10.2340/0001555566241244


Epidermal calmodulin levels were measured in lesional and non-lesional skin in 20 psoriatics before and after treatment by a variety of established topical and systemic regimes. Pretreatment, 10 out of 20 patients showed elevated calmodulin levels in lesional epidermis. Clearance of psoriatic plaques was accompanied by a significant overall reduction (p less than 0.05) in epidermal calmodulin, irrespective of the treatment regime used. For the non-lesional epidermis, only 5 out of 17 patients initially showed elevated calmodulin levels and there was no significant reduction in those levels following treatment.


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