Content » Vol 68, Issue 5

Transfollicular percutaneous absorption. Skin model for quantitative studies

Illel B, Schaefer H.
DOI: 10.2340/0001555568427430


Theoretically percutaneous absorption comprises two components: the transepidermal route and the transappendageal route, so-called ´shunt´ diffusion. The relative importance of ´shunt´ diffusion was investigated with a model of appendage-free skin. After treatment with 60 degrees C water for exactly 1 min, hairless dorsal rat skin regrows as a continuous epidermis. We present preliminary results of hydrocortisone diffusion in vitro, in appendage-free skin relative to normal skin. With intact skin under our experimental conditions, the steady-state flux and the total diffusion in 24 h were 50-fold larger.


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