Content » Vol 68, Issue 2

Proteolytic degradation of desmosomes in plantar stratum corneum leads to cell dissociation in vitro

Egelrud T, Hofer PA, Lundström A.
DOI: 10.2340/00015555689397


Pieces of plantar stratum corneum were incubated with trypsin. This resulted in cell dissociation. The only observable ultrastructural change caused by trypsin was a degradation of desmosomal plates between dissociating cells. This suggests that desmosomes are of primary importance in plantar stratum corneum cell adhesion.


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