Content » Vol 92, Issue 2

Letter to the Editor

Cutaneous Hyphomycosis Due to Paecilomyces lilacinus

Khaled Ezzedine1, Emilie Belin1, Stéphanie Guillet1, Mahussi D’Almeida2, Catherine Droitcourt1, Isabelle Accocebery2, Brigitte Milpied1, Thomas Jouary1, Denis Malvy3 and Alain Taieb1

1Department of Dermatology, 2Service de Parasitologie and 3Service de Médecine interne et maladies tropicales, Hôpital Saint André, CHU Bordeaux, France. E-mail:

Accepted April 28, 2011.

Skin infection with Paecilomyces lilacinus is a rare event, but one that is increasingly reported. The fungus may affect various organs, including the skin, eyes, sinuses, and lungs, with variable outcomes. There are no established guidelines for the management of P. lilacinus infection (1). We report here a new case of hyphomycosis related to P. lilacinus in a patient who had undergone uncontrolled courses of corticosteroid therapy.


A 60-year-old man was first seen at our department with multiple nodular lesions involving the nose and the right cheek, which had developed over a period of more than 4 months with gradual aggravation. In addition, a new lesion had developed on his left hand 2 months later. The patient had been treated unsuccessfully with oral antibiotics by his referent physician. His medical history was remarkable for rheumatoid arthritis, for which he had frequently undergone uncontrolled courses of oral corticosteroids (40 mg prednisone daily) over the last 10 years. Of note, the patient acknowledged having fallen when working in his garden 5 months previously, with multiple excoriations on the skin on his face. Physical examination revealed multiple tender subcutaneous nodules of varying size, involving half of his right face, including his nose, cheek and sub-palpebral skin, with a pseudo-verrucous aspect and small necrosis at the edge of the nose (Fig. 1a). Another erythematous lesion with an infiltrated pattern was also present on his left hand (Fig. 2). No palpable lymph nodes were noted. Blood laboratory examinations, including HIV serology, were normal. Histopathology of a biopsy sample from his cheek revealed the presence of a microgranulomatous infiltrate containing eosinophils and plasmocytes with a tendency to form micro-abscesses (Fig. 3). Periodic acid-Schiff (PAS) and Grocott-Gomori methenamine-silver staining revealed scanty hyphal elements with conidiophores into the deep dermis. In addition, direct examination and culture were performed twice on skin specimens taken from different lesions, and revealed hyaline, septate hyphae with a mould that grew rapidly within 4 days on Sabouraud-dextrose-agar medium containing chloramphenicol without cycloheximide, forming floccose, pinkish mauve colonies. Microscopic examination of slide cultures identified the mould as P. lilacinus, and this was further confirmed by PCR amplification. Antifungal susceptibility to various drugs showed the mould to be resistant to various antimycotic drugs, except for voriconazole and posaconazole. With regard to the localization of the infection, magnetic resonance imaging of the patient’s head was performed, and revealed right nasal sinusitis with an involvement of the ethmoidal cells. The patient turned down any additional surgical procedure and voriconazole was therefore introduced at a dosage of 200 mg twice daily. This medication was stopped after 10 days due to visual hallucinations. At that time, posoconazole was introduced at a dosage of 400 mg twice daily. The patient stopped taking the drug after 4 weeks because of anorexia associated with an involuntary weight loss of 5 kg. At week 4, clinical improvement was remarkable (Fig. 1b). The patient declined any other treatment and was lost to follow-up.


Fig. 1. (a) A 60-year-old patient with multiple tender subcutaneous nodules of varying size involving half of the right side of the face. (b) Remarkable improvement after one month treatment with posoconazole.


Fig. 2. Erythematous lesion with an infiltrated sporotrichoid pattern.


Fig. 3. Grocott-Gomori methenamine-silver staining of a skin specimen biopsy showing fungal elements with septate hyphae (× 200).


P. lilacinus is a hyaline hyphomycete that is found in soil and air, and has worldwide geographical distribution. Although considered to be rare and of moderate virulence, it may affect both immunocompromised and immunocompetent individuals (1). Moreover, the fungus is frequently resistant to conventional antifungal agents and may be resistant to sterilizing methods and be a recurrent contaminant of lotion. The fungus may therefore be responsible for the colonization of clinical material, such as catheters and plastic implants (2, 3). Thus, P. lilacinus has mainly been reported to cause eye infection following surgical procedures for cataract or intraocular lens implantation (4). Cases of cutaneous and subcutaneous P. lilacinus infections have rarely been described, although recent reports highlight the role of this fungus as an emerging pathogen for severe skin infection (5). It is probable that our patient was contaminated by direct inoculation following minimal skin abrasion (6). Clinical features of skin infections related to P. lilacinus may vary greatly. Hence, in our patient, two distinct clinical features depending on the involved site were noted, i.e. infiltrated lesions of the hand and subcutaneous nodules of the face. Moreover, sinusitis related to P. lilacinus has been very sparsely reported and usually follows surgical procedures (4). Most fungal sinusitis usually occurs in deeply immunocompromised patients and is linked to Aspergillus species. Fungal infection with P. lilacinus was first reported in an adult female in 1982 (7). Since then other cases of such infections have been reported in immuno-compromised individuals. However, to the best of our knowledge this is the first reported case of both cutaneous and sinuses infection in a patient who had never undergone facial surgery. In our patient, sinusitis is probably related to the proximity of the initial lesion with paranasal sinuses, which may have been further contaminated. There is no standard therapy regimen for P. lilacinus infection. However, because of its high resistance to conventional azoles, novel antifungal drugs, such as voriconazole and posoconazole, which have shown in vitro activity against the mould, are usually preferred.

In conclusion, P. lilacinus infection is increasingly reported as a pathogen. The diagnosis of this rare cutaneous infection should be considered not only in transplant recipients receiving immunosuppressive drugs, but also in patients undergoing long-term therapy with oral corticosteroids. Antifungal susceptibility testing should be performed when possible due to the frequent resistance of the mould to conventional azoles.

The authors declare no conflict of interest.


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