Caroline Mann, Matthias Dreher, Hans-Günter Weeß, Petra Staubach
Little is known about the relationship between sleep disturbances and dermatologic diseases, yet the majority of the patients report sleep problems during a disease flare. The goal of this study was to show the relevance of insomnia in urticaria and atopic dermatitis patients and to shed light on this underestimated burden.
Julie Sophie Hohwü Elsner, Michael Carlsson, Julie Kristine Stougaard, Uffe Nygaard, Matthias Buchner, Regina Fölster-Holst, Malene Hvid, Christian Vestergaard, Mette Deleuran, Bent Deleuran
Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of TH2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow c ...
Isabel Belinchón, MarÃa J. Sánchez-Pujol, Alejandro Docampo, Laura Cuesta, Luca Schneller-Pavelescu, Jose M. Ramos-Rincón
The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n =â ...
Roel E. Genders, Nick Marsidi, Marlies Michi, Erik P. Henny, Jelle J. Goeman, Marloes S. van Kester
The treatment of choice for cutaneous squamous cell carcinoma is complete surgical excision. Incomplete excision of cutaneous squamous cell carcinoma has an increased risk of local recurrence, deep subclinical progression, and metastasis. This study aimed to investigate the proportion and risk factors of incomplete excised cutaneous squamous cell carcinoma. A systematic review of the literature wa ...
Juliane Weilandt, Katharina Diehl, Marthe Lisa Schaarschmidt, Felix Kieker, Bianca Sasama, Melanie Pronk, Jan Ohletz, Andreas Könnecke, Verena Müller, Jochen Utikal, Uwe Hillen, Wolfgang Harth, Wiebke K. Peitsch
Treatment paradigms for advanced melanoma have changed fundamentally over recent years. A discrete choice experiment was performed to explore patient preferences regarding outcome (overall response rate, 2-year survival rate, progression-free survival, time to response, type of adverse events, probability of adverse event-related treatment discontinuation) and process attributes (frequency and rou ...
Zhihong Zuo, Ben Wang, Minxue Shen, Hongfu Xie, Ji Li, Xiang Chen, Yiya Zhang
The pathogenesis of rosacea remains unclear but has been reported to correlate with skin barrier function. The objective of this study was to elucidate the skincare habits of Chinese adolescents and determine the relationship between skincare habits and rosacea. A university-based cross-sectional investigation included 310 rosacea cases and 3,129 healthy controls who underwent health examinations ...
Gudrun Schneider, Anna Grebe, Philipp Bruland, Gereon Heuft, Sonja Ständer
While psychological factors are relevant in many patients with chronic pruritus, not all patients can be offered psychologic, psychosomatic or psychiatric consultation. The aim of this exploratory study was to identify criteria suggestive of psychological factors relevant for the etiology of chronic pruritus and of somatoform pruritus. Routine data from the database of the Center for Chronic Pruri ...
Caroline Mann, Matthias Dreher, Hans-Günter Weeß, Petra Staubach
This study examined the relationship between insomnia and the frequent itching skin diseases, atopic dermatitis and chronic urticaria. Patients with chronic inflammatory dermatological diseases with pruritus were evaluated for insomnia (Insomnia Severity Index; ISI) and impairment in dermatological quality of life (Dermatology Life Quality Index; DLQI). Disease activity was measured using validate ...
