Content - Volume 62, Issue 2
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Mononuclear cells in the dermis were characterized and counted in cryostat sections of lesional skin from 34 patients with various clinical forms of psoriasis. T lymphocytes were detected with F(ab´)2 preparation of rabbit IgG against human T lymphocytes and acid alpha-naphthyl acetate esterase (ANAE) activity as histochemical marker. The ANAE method was also used for the detection of macrophages ...
A young female with local panatrophy of the right-side extremities affecting all mesodermal layers--dermis, subcutaneous tissue, muscles, and bone--is described. The atrophies were strictly linear. Ultrastructurally, collagen fibrils of the reticular dermis from the atrophic area consisted of two types, a large population of fibrils with decreased diameter and round cut-surface, and a small popula ...
Histometric and autoradiographic methods were applied to investigate the actions of sex hormones on the cultured epidermis of post-menopausal women. Both testosterone and progesterone at the concentration of 10(-9)-10(-7) mol/l enhanced the keratinization of the epidermal cells during the 7-day culture. The numbers of the granular cells were increased by both of these hormones and the transit time ...
The ultrastructure of C. neoformans was studied in two cases of cutaneous cryptococcosis. Extracellular and intracellular fungi were observed. Their capsules and clear zones were thick and distinct, but their cytoplasmic organelles were not obvious. In macrophages, a few stages of fungal degeneration could be observed. It could not be ascertained whether the changes were caused by anti-fungal drug ...
25 cases of cutaneous lymphocytoma were reviewed, of which 13 were benign lymphocytoma of the skin and 15 lymphocytic infiltration of the skin (Jessner). The clinical diagnosis benign lymphocytoma of the skin was in agreement with the histology, except in 2 patients where lymphocytic infiltration of the skin (Jessner) was the most likely clinical diagnosis. Of the 15 patients treated, 8 went into ...
In a previous study on lichen planus the morphology and significance of the colloid bodies were discussed (13). In the present study a description is given of 30 dermatoses with colloid bodies, observed among unselected patients. The colloid bodies develop as a result of damage to the epithelium caused by circulatory disorders with subsequent hypo- or anoxia. Lichenoid cell infiltration into the c ...
Guinea pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UVB radiation on the right flank for a period of 12 days. The response to an elicitation dose of DNCB was diminished in the irradiated skin immediately after UV treatment. This effect was dose-dependent. No reduction in the response could be demonstrated in unexposed skin. One week after UVB treatme ...
The itch and flare responses induced by intradermal injection of histamine and the histamine liberator compound 48/80 were studied in healthy volunteers before and after exposure to UVB, UVA or PUVA administered 2-3 times weekly for 4 weeks. All three modalities were found to inhibit the responses induced by compound 48/80. The degree of tanning was most pronounced after PUVA and weakest after UVB ...
Six patients are described who experienced a prodromal period suggesting an infective process, followed by a distinctive polymorphous cutaneous eruption. The most striking lesion, present in all of them and giving the eruption a distinctive herpetiform appearance, included closely grouped vesicles resting on an erythematous base. Histopathological examination of these lesions showed features of de ...
The provocation of erythema craquel?© after cessation of long-term continuous steroid application to normal skin was investigated in 58 healthy subjects, usually under occlusion. No correlation was demonstrated between the erythema craquel?© and skinfold thickness measured with the Harpenden technique.
One of the prepolymers used in Ultraviolet (UV) curing ink formulations is acrylated polyester. The prepolymer investigated is a dimethacrylated polyester, thus a saturated polyester terminated with methacrylic groups. In conventional UV-curing coatings the prepolymer commonly used is an unsaturated polyester. Three of six workers with dermatitis from UV-curing inks in printing plants had positive ...
HLA-A, B, C and Bf typing was performed in 55 cases of Discoid Lupus Erythematosus (DLE). When both the sex and age of the patient at the onset of the disease were taken into consideration (group I under 40 years, group II over 40), the following increases in antigen frequency were observed: group I: A2 in women, B5, A10 in men; group II: Aw19.2 in women, B8 in both sexes. Nevertheless, if the pro ...
No abstract available.
During the period from 1977 to 1980 eleven cases of T. tonsurans infections were diagnosed in the Mycology Laboratory, Department of Dermatology and Venereology, Odense University Hospital, Denmark. All patients were adults and none had tinea capitis. Five patients had tinea pedis, 5 tinea ungvium, 2 tinea cruris, one tinea manuum, and one tinea glabrosa.
Oral retinoids seem to have been of great benefit in a non-randomized study on advanced mycosis fungoides using two different chemotherapy regimens, one with retinoid, the other without. Both groups also received a 3-drug chemotherapy with bleomycin, cyclophosphamide and prednisone. Complete remission including all signs of lymph-node involvement was found in 8 of 10 patients of the retinoid treat ...
Oral leukoplakia patients who were smokers were asked to give up their smoking habits. It was found that leukoplakias present in persons with smoking habits might be reversible, when the smoking habit was reduced or given up. Leukoplakias which were not reversible could possibly be of the same idiopathic type as leukoplakias in non-smokers.
Griseofulvin at 2-17 micrograms/ml in in vitro inhibited the proliferation of scleroderma skin fibroblasts and rheumatoid synovial cells. The inhibition was concentration-dependent, with little difference between the two types of cells. Mean ID50 values from the four strains of each group were 9.2 for fibroblasts and 9.5 for synovial cells. The results show that griseofulvin at therapeutic concent ...
No abstract available.
Three cases of cutaneous vasculitis, leukocytopenia and arthralgia, presumably caused by the antithyroid drug Propylthio-uracil, are presented. Acute vasculitis of the superficial and deep dermal blood vessels accompanied by vascular thrombus formation were found in biopsy specimens. Direct immunofluorescence studies demonstrated deposits of C3 or IgM and C3 in the walls of vessels in affected and ...
A 73-year-old man developed a malignant clear cell hidradenoma on the nose. Although it was treated solely with diathermy and curettage it did not recur. These rare tumours are histologically malignant but do not always behave aggressively. In some patients local growth and recurrence may occur, while in others the tumour metastasizes widely. There is no way of predicting how these tumours will be ...
A patient with the Klippel Trenaunay Weber syndrome presented with prolonged bleeding from the finger tips during strenuous exercise. Tissue fibrinolysis studies showed increased fibrinolytic activity suggesting that the blood vessels in the affected limb may be functionally as well as anatomically abnormal.
No abstract available.
Cartilaginous nevus usually occurs in front of the auricle as an accessory auricle and much less frequently on the cheek or anterior part of the neck. We report a case of cartilaginous nevus found on an unusual location, The glabella of the face, in an otherwise normal newborn girl. We think that it was a remnant of the branchial cartilage derived from the first pharyngeal arch of embryonic life.
A new wax formulation of anthralin was compared with anthralin as used in the Ingram regimen for the treatment of chronic discoid psoriasis. In 16 out-patients 12 of the 13 who responded to the Ingram regimen also showed a satisfactory response to the wax preparation. The latter could be applied more rapidly and simply and may thus have a useful place in the domestic management of chronic psoriasi ...
No abstract available.