Content - Volume 64, Issue

All articles

The influence of ultraviolet B irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha in psoriatic and normal subjects
Katayama H, Hori H.
The influence of ultraviolet B (UVB) irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 7 normal male volunteers and 7 male patients with stable psoriasis was examined. The excretion of PGF-MUM was increased during the first 24 hours after UVB irradiation of back skin and was generally reduced to near pre-irradiation levels during the ne ...
Pages: 1-4
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Activation of complement in the skin after PUVA therapy
Clemmensen OJ, Staberg B, Worm AM.
Suction blister fluid from the abdominal skin of 14 healthy subjects was examined for the presence of split products of complement C3 (C3-split) as an indicator of complement activation before and after treatment with either UVA or PUVA. Following PUVA a significant increase in C3-split was found (p less than 0.05) in both irradiated and non-irradiated skin areas. Following UVA the increase in C3- ...
Pages: 5-8
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Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment
Michaëlsson G, Edqvist LE.
The glutathione-peroxidase (GSH-Px) activity in erythrocytes was determined in 42 men with severe acne and 47 women with acne--26 of a moderate degree and 21 severe. The male acne patients had significantly lower GSH-Px levels than the controls. The women with acne did not differ significantly from the controls in this respect when patients and controls using oral contraceptives were excluded. Bot ...
Pages: 9-14
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13-cis-Retinoic acid in rosacea. Clinical and laboratory findings
Schmidt JB, Gebhart W, Raff M, Spona J
The paper presents clinical and laboratory data on 13-CIS-retinoic acid treatment in rosacea. Good-to-excellent results are reported for severe forms of rosacea. Side effects were tolerable and could easily be controlled. The role of sebaceous gland function was documented by both histological and skin sebum parameters. Diminution of sebaceous gland size and the decrease of skin sebum with alterat ...
Pages: 15-21
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Free fatty acids in the blood serum of psoriatics
Zlatkov NB, Ticholov JT, Dourmishev AL.
Free fatty acids in the serum of 60 patients with generalized psoriasis were studied by a gas-chromatographic method. The same investigations in 40 healthy persons served for control purposes. It was established with statistical probability (p less than 0.001) that in the serum of psoriatics the levels of palmitic (C 16: 0), stearic (C 18: 0), arachidic (C 20: 0), and docosadienic (C 20: 2) acids ...
Pages: 22-25
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Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata
Perret C, Wiesner-Menzel L, Happle R
In 11 patients with untreated alopecia areata in the progressive stage of the disease, an in situ analysis of the inflammatory infiltrate of the hair bulbs was performed by means of different monoclonal antibodies. Most of the peribulbar cells reacted with the pan T-cell antibodies OKT 3 and Lyt 3. Staining for T-cell subsets revealed that the proportion of OKT 4+ cells was about fourfold higher t ...
Pages: 26-30
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Abnormal amino acid composition of nails in Bazex´s paraneoplastic acrokeratosis
Juhlin L, Baran R.
Bazex´s paraneoplastic acrokeratosis is a syndrome with psoriasiform acral hyperkeratosis and nail changes associated with carcinoma of the upper respiratory or alimentary tract. We report here a case where amino acid analysis of the hyperkeratotic and friable nails differed from normal and other diseased nails investigated by us, but they were similar to those reported in trichothiodystrophy or ...
Pages: 31-34
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Quantification of acrosclerosis: measurement of skin thickness and skin-phalanx distance in females with 15 MHz pulsed ultrasound
Serup J.
The skin thickness of the extensor and flexor aspects of the forearm (TEF, TFF), and the skin-phalanx distance over the middle and proximal phalanges (DMP, DPP) were measured with a 15 MHz ultrasound (A-scan) apparatus. Twenty-two females with systemic sclerosis (acrosclerotic type) and 22 healthy females matched for age were studied. DMP, DPP, TEF and TFF measurements were all increased in system ...
Pages: 35-40
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Assessment of atrophy of human skin caused by corticosteroids using chamber occlusion and suction blister techniques
Somerma S, Lassus A, Salde L.
The effect of five corticosteroid ointments on epidermal thickness was studied using occlusive chamber application. Thinning of the epidermis and telangiectasia were noted 3 weeks after application of betamethasone-17-valerate (BV), budesonide (BD), clobetasol-17-propionate (CP), and fluocinolone acetonide (FA), but not of hydrocortisone (HC). Suction blisters were raised at the treated sites. Epi ...
Pages: 41-45
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Lymphomatoid papulosis: a follow-up study
Lange-Wantzin G, Thomsen K, Hou-Jensen K.
A follow-up study has been performed on 16 patients with lymphomatoid papulosis diagnosed at the Finsen Institute during the years 1970-81. In none of the patients did malignant lymphoma develop during the observation period (7 months to 22 years). During this period the nature of the lesions and the tendency to recurrence were unchanged in 11 patients, spontaneous remission took place in 4, and 1 ...
Pages: 46-51
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Lichen planus and chronic active hepatitis. A retrospective survey
Rebora A, Rongioletti F.
In a retrospective survey 95 in-patients with non erosive lichen planus (LP) were summoned to be investigated by means of routine liver tests. 44 patients responded. Remarkable abnormalities of liver tests were found in 6 patients who were further studied for antibodies to smooth muscle and mitochondria and submitted to liver biopsy. Histological diagnosis revealed chronic active hepatitis (CAH) i ...
Pages: 52-56
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Occurrence of epidermolysis bullosa in Finland
Kero M.
Cases of epidermolysis bullosa (EB) were gathered from the hospital files of dermatological clinics and university pediatric clinics in Finland over a period of 10 years. 40 families were identified, containing 121 live sufferers from this condition, after which genealogical analysis revealed a further 55 patients. 11 out of the 17 subtypes of EB (1) were diagnosed in these families. The diseases ...
Pages: 57-62
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Antipsoriatic activity of 10-acyl analogues of dithranol (anthralin). I. Phase I clinical trial of 10-propionyl dithranol and 10-butyryl dithranol (butantrone)
Mustakallio KK, Brandt H.
Dithranol, 10-propionyl dithranol and 10-butyryl dithranol were compared as regards their antipsoriatic, staining and irritative properties. They were applied under 12-mm Finnchambers on the lesional skin of 17 psoriasis patients every second day for 20 days. In 9 patients their concentration was equimolar (2 mmol/kg of white petrolatum) corresponding to 0.05% dithranol, and in 8 patients the conc ...
Pages: 63-66
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Ultrasonic B-scanning of the human skin. An introduction of a new ultrasonic skin-scanner
Tikjøb G, Kassis V, Søndergaard J.
A high frequency, high resolution dynamic ultrasonic skin-scanner is described. The skin-scanner is shown to give a cross-sectional image of the skin and provides an accurate, simple and non-invasive method for measuring full-thickness human skin. In addition to the skin thickness it is demonstrated that the underlying subcutaneous fat and muscles can also be non-invasively explored with the possi ...
Pages: 67-70
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Incidence of liver disease in chronic lichen planus of the mouth
Mobacken H, Nilsson LA, Olsson R, Sloberg K.
Fifty-four patients with oral lichen planus were screened for chronic inflammatory liver disease utilizing standard biochemical parameters of liver function, serum levels of immunoglobulins G, A and M and circulating autoantibodies against mitochondriae, smooth muscle and cell nuclei. One patient had primary biliary cirrhosis, and another had cryptogenic cirrhosis. This study did not confirm previ ...
Pages: 70-73
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The influence of the opiate antagonist naloxone on experimental pruritus
Fjellner B, Hägermark O.
The antipruritic effect of naloxone hydrochloride was evaluated in a double-blind, cross-over design. Systemic pretreatment with the opiate antagonist did not interfere with the cutaneous itch and flare responses evoked by morphine or histamine, nor did it inhibit the morphine-produced potentiation of the histamine-elicited skin reactions.
Pages: 73-75
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Treatment of pustulosis palmaris et plantaris with colchicine. A double-blind cross-over trial
Thestrup-Pedersen K, Reymann F.
27 patients with pustulosis palmaris et plantaris were treated daily with colchicine 0.5 mg X 3 for four weeks in a double-blind study. Only ten patients experienced a halt of pustule formation, whereas redness, scaling, and subjective symptoms were unchanged. Colchicine seems of limited value in patients with pustulosis palmaris et plantaris.
Pages: 76-78
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Bowel bypass arthritis dermatitis syndrome: a histological and electron microscopical study
Sandbank M, Weltfriend S, Wolf R.
A case of dermal vasculitis with arthralgia after intestinal bypass surgery is reported. A 36-year-old woman developed arthralgia and skin rash, 1 year after an ileo-jejunal bypass operation was performed for overweight (130 kg). Skin biopsy showed leucocytoclastic vasculitis in the dermis. E.M. study showed clumps of platelets around small dermis blood vessels, and polymorphous perivascular infil ...
Pages: 79-82
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Spontaneous regression of generalized molluscum contagiosum turning black
Ogino A, Ishida H.
In this report, the unusual case of an infant with extensive eruptive molluscum contagiosum (MC) scattered over the back and buttocks that became inflammatory with blackening and subsequently healed spontaneously over a short period of time is described. To our knowledge, the blackening of spontaneous regressing MC has not yet been described. The mechanism involved in the phenomenon of spontaneous ...
Pages: 83-85
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Follicular mucinosis developing into cutaneous lymphoma. Report of two cases and review of literature and 64 cases in Japan
Kanno S, Niizuma K, Machida S, Takahashi M, Ohkido M, Nagura H, Murakosi M, Mori T.
Two cases of follicular mucinosis which developed into lymphoma are reported. The infiltrative atypical lymphocytes proved to be T cells, which were identified by monoclonal antibodies. The association of follicular mucinosis and lymphoma in Japan is estimated to be 9.4%.
Pages: 86-88
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Angioendotheliosarcoma of the nose--a case report
Waersted A, Andersen KE, Hansen JP.
Angioendotheliosarcoma of the face or scalp is regarded as a highly malignant tumor. We present a case with onset as a purple macule on the nose, suspected to be rosacea, and emphasize the use of early skin biopsy when a red or purple discoloration is seen in the face of elderly people.
Pages: 88-90
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