Content - Volume 65, Issue 6

Effects of a new synthetic retinoid, 3, 7, 11, 15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (E-5166), on the cyclic AMP system of pig skin epidermis was investigated. When pig skin slices were incubated in vitro for 24 h, the beta-adrenergic adenylate cyclase response (epinephrine-induced cyclic AMP accumulation) was decreased. The addition of E-5166 in the incubation medium resulted in an i ...

A quantitative model of contact allergy to picryl chloride in the mouse was used to evaluate the influence of locally administered ultraviolet light (UVB) on sensitization and challenge. UVB was given in three different doses immediately before and 24 h before sensitization and challenge, respectively. A suppressive effect was demonstrated on the afferent as well as on the efferent limb of the all ...

The sensitizing potential of aqueous formaldehyde was evaluated with the guinea pig maximization test (GPMT) in two laboratories (Copenhagen and Stockholm) using different guinea pig strains. Six intradermal (0.01%-3%), and 6 topical (0.5%-20%) concentrations were used for induction, and formaldehyde 1% and 0.1% was used for challenge. The incidence of contact sensitivity depended on the intraderm ...

Inflammatory cells in 15 specimens of normal human epidermis were selectively stained by a monoclonal antibody immunoperoxidase technique. The quantitative assessment using an interactive image analysis system revealed OKT 11 positive cells (T lymphocytes) and Leu 2a positive cells (suppressor/cytotoxic cells). As there was no significant difference in the distribution of these markers, helper/ind ...

Rabbits were immunized using isolated and dissolved specific immune complexes obtained from patients suffering from early syphilis. After immunization the rabbits were infected intradermally with living Treponema pallidum. Some of them did not develop lesions at the infection sites. In comparison to controls there was a delayed and reduced production of antibodies. The effect of immunization may b ...

Three children with classical Ehlers-Danlos syndrome were studied. Electron microscopic observation of the skin demonstrated a hyaluronic acid-dominant glycosaminoglycan structure in the intercellular matrix. Biochemical analysis showed a significant increase in hyaluronic acid content, as compared with the skin of sex- and age-matched children, including a non-affected brother of a patient. In ad ...

Necrotizing fasciitis (NF) is a grave infection of the skin leading to gangrene of the integument and often having a complicated and prolonged course. Studies on blood coagulation and fibrinolysis were done in 15 patients with NF and compared with 5 cases of erysipelas (E). In both conditions local fibrin deposition occurred initially in their course, but it was quantitatively more pronounced in N ...

Experimentally-induced mental stress activates the psychoneuroendocrine systems. The cutaneous (itch and flare) responses of human skin to intradermal injection of histamine remain despite this unaltered. Major interindividual differences, however, exist in both neurophysiological reactions and cutaneous reactivity. The individual skin responses are interrelated to the urinary adrenaline response ...

To determine whether antibodies to Borrelia spirochetes were present, sera from 88 patients with uncomplicated erythema chronicum migrans Afzelius (ECMA), from 9 patients with ECMA-related extracutaneous complications and from 26 patients with acrodermatitis chronica atrophicans (ACA) were submitted to an enzyme-linked immunosorbent assay (ELISA) and an indirect immunofluorescence (IF) assay. The ...

Immunological and mycological investigations were carried out in 21 Swedish homosexual males. One of them had AIDS, one pre-AIDS and 19 lymphadenopathy of whom 18 fulfilled the criteria of persistent generalized lymphadenopathy (PGL) as defined by the Centers for Disease Control, Atlanta, (CDC). The patients were investigated immunologically with respect to their in vitro lymphocyte reactivity to ...

Review of 4 430 patients with a diagnosis of scleroderma, morphea, or eosinophilic fasciitis has revealed 16 patients with one of a variety of serious hematologic diseases. Although it is not possible to comment on the exact relationship between the dermatologic disease and the hematologic disorder, in seven patients there appeared to be a close temporal relationship between the onset of the two c ...

Two cases of epidermolysis bullosa simplex localisata associated with anodontia, hair and nail disorders were described. It was proved that the reported cases represented a new syndrome, which had previously not been published. The syndrome was named "Syndroma Kallin" after the surname of the two patients. Two genetic theories were suggested: an autosomal recessive genetic trait or a gonadal mosai ...

Forty patients suffering from pustulosis palmoplantaris were treated with PUVA therapy. Thirty-six patients had palmar lesions which cleared in 31 cases; in 18 cases after an initial course of 3 sessions of treatment per week during an average period of 10 weeks, and in another 13 only after additional, less frequent continuation of the PUVA therapy. The average total UVA dose at clearing of the p ...

Experimental infections with Trichophyton mentagrophytes and Trichophyton rubrum were performed on human hair in vitro and studied by conventional light microscopy, scanning (SEM) and transmission (TEM) electron microscopy. The penetrations visible by light microscopy in hair infected with T. mentagrophytes appeared at SEM as disrupted surface areas with perforating holes. T. rubrum-infected hair ...

A rapid processing technique for ultrastructural studies of human epidermis has been devised in order to reduce dislocation of soluble compounds and to make available sections for diagnostic purposes within reasonable time (ca 4 hours). The morphology of cellular components agreed with or improved upon that obtained after commonly used methods. Thus, for example, the substance in the intercorneal ...

Pregnant women and women taking oral contraceptives show urinary excretion values of 5-S-cysteinyldopa and of 6-hydroxy-5-methoxyindole-2-carboxylic acid in the same range as nonpregnant women not taking oral contraceptives. The excretion of these melanoma markers can therefore be used in in the biochemical diagnosis of metastatic melanoma in pregnancy and in women taking oral contraceptives.

Heparin administration to 34 patients with pemphigus vulgaris before the beginning of steroid treatment or in combination with it proved to be therapeutically useful. Its suppressive effect on T- and B-lymphocytes in vitro and in vivo was revealed in the examined patients by the test of rosette-formation.

Thirteen patients with contact allergy to phenol-formaldehyde resins (P-F-R) were patch tested with 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol. Nine patients reacted to at least 1 compound, all giving positive test responses to 2,4-dimethylol phenol. Seven patients reacted simultaneously to 2,6-dimethylol phenol while only 1 patient reacted to 3-methylol phenol. Negative te ...

Sub-populations of leucocytes, complement C3, CRP, alpha 2 macroglobulin and immunoglobulin levels were measured in the peripheral blood of 28 (14 male, 14 female) normal control subjects and 108 (53 male, 55 female) acne patients. Significantly increased levels of inflammatory mediators were found much earlier in female than in male acne patients. The female defence system would seem to be more c ...

A patient with epilepsy and psoriasis in phenytoin therapy was treated with PUVA with no effect at all. The PUVA treatment failure was demonstrated as being due to abnormally low serum levels of 8-methoxypsoralen (8-MOP) during phenytoin therapy, while normal serum levels of 8-MOP were observed after phenytoin was discontinued. The effect is probably due to an induction of the hepatic enzyme syste ...

In a 72-year-old man two malignant melanomas had developed simultaneously during long-term treatment with levodopa. Although a causal relationship between tumour growth and administration of levodopa can only be suspected, such a possibility should be considered when using this drug.

Here we report the case of a patient who developed drug fever during PUVA treatment. This was the only manifestation of hypersensitivity. Neither UV-A irradiation nor 8-methoxypsoralene caused a febrile reaction.

We report five patients in whom localised callosities were found on the dorsum of the feet. This was bilateral in four cases and was due to repetitive minor trauma associated with the sitting posture adopted by the patients. Three of the patients also had psoriasis vulgaris which was clinically dissimilar to the lesions we describe.

Three women with hyperkeratosis lenticularis perstans (HLP) are described. The lesions developed after the age of 45 and there was no family history of this disease. The possible role of UV-light in the pathogenesis of this disease is discussed.

A 58-year-old woman developed Sweet´s syndrome one week after a flu-like illness. She was later found to have a centrocytic/centroblastic non-Hodgkins lymphoma. Six courses of chemotherapy were given during which the lesions of Sweet´s syndrome resolved completely. As far as we are aware this is the first report of the association of Sweet´s syndrome with a lymphoma.

The incidence rate of acquired syphilis per 100 000 total population in Denmark increased by 70% from 6.8 in 1978 to 11.6 in 1982. In 1984 this incidence had decreased by 61.2% to 4.5. The fluctuation of the number of acquired syphilis predominated in the male population with an increase of 71.8% during the five year period 1978-1982 and a decrease of 63.2% during the years 1983 and 1984. In 1978, ...

No abstract available.