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Content - Volume 71, Issue 3

All articles

Serum aminoterminal propeptide of type III procollagen in systemic sclerosis. A follow-up--investigations in subclasses and during therapy.
Heickendorff L, Parvez A, Bjerring P, Halkier-Sørensen L, Zachariae H
Fifty-seven patients with systemic sclerosis were investigated for connective tissue turn-over related to type III collagen. Sera from 13 patients with diffuse cutaneous systemic sclerosis and 44 patients with limited cutaneous systemic sclerosis were analysed for aminoterminal propeptide of type III procollagen (PIIINP) by a radioimmunoassay based on human propeptide. Increased levels of PIIINP i ...
Pages: 185-188
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Use of anti-collagenase properties of doxycycline in treatment of alpha 1-antitrypsin deficiency panniculitis.
Three patients (a 71-year-old man and 2 women, 73 and 50 years, respectively) with recurrent panniculitis associated with alpha 1-antitrypsin deficiency are presented. Because the concept of chronic and exaggerated inflammatory response in the patients with alpha 1-antitrypsin deficiency is based on the theory of protease-antiprotease imbalance, we suggest that tetracyclines will alleviate this co ...
Pages: 189-194
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Inhibition of basal cell proliferation during storage of detached cultured epidermal keratinocyte sheets.
Poumay Y, Boucher F, Degen A, Leloup R
Grafting of human cultured keratinocytes is a promising possibility for the treatment of large burned skin areas. However, during the preparation of cultures for grafting, a necessary step of detachment from culture substratum is performed by incubation with Dispase. In the present paper, we report studies performed to determine whether prolonged storage after detachment would have a detrimental e ...
Pages: 195-198
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Dose-response relationship between objective measures of histamine-induced weals and dose of terfenadine.
Shall L, Newcombe RG, Lush M, Marks R
Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared with pre-treatment measurements, in order to compare the dose-effect relationship and time course of the different dosages. In a double-blind randomized cr ...
Pages: 199-204
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Perception of histamine-induced itch elicited in three different skin regions.
Wahlgren CF, Ekblom A
In order to investigate whether any regional difference in itch perception exists in experimentally induced pruritus, various concentrations of histamine (1, 3.3, 10, 33 and 100 micrograms/ml) were injected intradermally in three different skin regions in 15 healthy subjects. The regions were 1) the volar aspect of the forearm, 2) the lateral aspect of the upper arm and 3) the upper back at scapul ...
Pages: 205-208
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Quantification of Birbeck's granules in human Langerhans' cells.
Bartosik J, Lamm CJ, Falck B
A proper understanding of the function of Birbeck's granules requires that they should be counted under various conditions. We now present a simple quantification method which does not depend on specific assumptions concerning size, shape or location of the particles counted and can, moreover, be applied for counting other subcellular structures as well. A population of 69 serially sectioned human ...
Pages: 209-213
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Multihormonal response to dexamethasone. A study in atopic dermatitis and normal controls.
Rupprecht M, Rupprecht R, Koch HU, Haack D, Müller OA, Hornstein OP
Although minor disturbances of the circadian serum cortisol rhythm and diminished excretion of steroid metabolites have been reported in patients with atopic dermatitis, test assays regarding subtle neuroendocrine alterations have not been employed so far. We therefore studied the serum concentrations of cortisol, prolactin and adrenocorticotropin under baseline conditions, after 1 mg dexamethason ...
Pages: 214-218
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Local cholinergic sweat stimulation in atopic dermatitis. An evaporimetric study.
Kiistala R1, Kiistala U, Parkkinen MU
In atopic dermatitis the nature of potential sweating disturbances is still obscure. Using an evaporimeter, local sweating response to a supra-threshold concentration of methacholine and baseline water loss were measured from non-eczematous back skin of 167 young males in five main groups (pure atopic dermatitis, atopic dermatitis with rhinitis/asthma, rhinitis/asthma, non-atopic dermatosis, and n ...
Pages: 219-223
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Levels of essential and other fatty acids in plasma and red cell phospholipids from normal controls and patients with atopic eczema.
Oliwiecki S, Burton JL, Elles K, Horrobin DF
Blood samples were collected from 48 atopic eczema patients and 33 normal subjects in Bristol, and from 434 normal individuals worldwide. In the plasma phospholipids in the atopic eczema patients, the concentrations of linoleic acid and the ratio of linoleic acid to its metabolites were significantly elevated as compared with both sets of controls. In the atopic eczema patients there were major ab ...
Pages: 224-228
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Nocturnal growth hormone release in children with short stature and atopic dermatitis.
David TJ, Ferguson AP, Newton RW
This study was designed to test the hypothesis that children with atopic dermatitis and short stature fail to release growth hormone after falling asleep. Peak serum growth hormone response to arginine was compared with peak growth hormone concentration during sleep in 6 children with atopic dermatitis and short stature (greater than 3 SD below the mean) aged 7 to 12 years, and 5 control children ...
Pages: 229-231
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Histochemical localization of hyaluronan in psoriasis, allergic contact dermatitis and normal skin.
Wells AF, Lundin A, Michaëlsson G
In suction blister fluid from active psoriatic lesions we have previously found elevated concentrations of hyaluronan. The aim of this investigation was to study the localization of hyaluronan with a histochemical method, in biopsy specimens from lesions of 13 patients with progressive psoriasis. Ten normal subjects and seven patients with allergic contact dermatitis were also studied. In normal e ...
Pages: 232-238
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UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities in human keratinocytes in vitro.
Punnonen K, Puntala A, Jansén CT, Ahotupa M
Exposure of human keratinocytes to UVB irradiation resulted in formation of conjugated double bonds and thiobarbituric acid reactive material. The activities of superoxide dismutase and catalase, enzymes which protect cells against oxidative damage, were concomitantly reduced. The present study suggests that in keratinocytes, exposure to UVB irradiation leads to a chain of events resulting in lipi ...
Pages: 239-242
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Long-term follow-up of lichen planus.
Irvine C, Irvine F, Champion RH
Several large series of patients with lichen planus were reported some 30 years ago but no recent large surveys have been published. In this study, detailed enquiry was made into the natural history of the disease in 214 patients followed up 8 to 12 years after presentation to the Dermatology Department. The key findings from this study showed that the mean age of onset of lichen planus in males w ...
Pages: 242-244
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Effect of a new narrow-band UVB lamp on photocarcinogenesis in mice.
Flindt-Hansen H, McFadden N, Eeg-Larsen T, Thune P
Thirty lightly pigmented hairless (Hr/Hr) mice were irradiated 5 days per week for 30 weeks to assess the photocarcinogenicity of a new Philips TL 01 narrow-band (311 nm +/- 2) UVB lamp. All mice were found to be tumour-bearing after 16 weeks and histologically, 83% of these had definite squamous cell carcinomas. Compared with our previous study where conventional broad-band Philips TL 12 UVB irra ...
Pages: 245-248
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Reticulate hyperpigmentation of Iijima, Naito and Uyeno. A European case.
Björngren H, Holst R
A 15-year-old girl is presented with symmetric, hyperpigmented streaks and whorls on trunk and extremities. The pigmentation is located in the basal layer of the epidermis. The clinical and histopathological picture seems to be identical to the reticulate hyperpigmentation of Iijima, Naito and Uyeno, hitherto only described from Japan.
Pages: 248-250
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Crusted scabies in acquired selective IgA deficiency.
Shindo K, Kono T, Kitajima J, Hamada T
Crusted scabies, an unusual clinical variant of human scabies mite infestation, is usually reported in cases of gross debility, mental deficiency, or immunosuppression. We report here the occurrence of crusted scabies in a 40-year-old man with acquired selective IgA deficiency suspected to be caused by long-term medication with phenytoin for epilepsy.
Pages: 250-251
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Subclinical human papilloma virus infection in condylomata acuminata patients attending a VD clinic.
Sand Petersen C, Albrectsen J, Larsen J, Sindrup J, Tikjøb G, Ottevanger V, Karlsmark T, Fogh H, Mellon Mogensen A, Wolff-Sneedorff A
In 37 (77%) of 48 patients with external genital warts, application of 5% acetic acid revealed areas of acetowhite epithelium. The lesions were not clinically apparent before acetic acid was applied but were easily detected without the use of a colposcope. In a control group of 20 patients with chlamydial urethritis and no history of genital warts, none had acetowhite genital lesions. Histological ...
Pages: 252-255
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Systematized keratotic nevus with finger contracture.
Fukamizu H, Ichikawa H, Iwatsuki K, Takigawa M
A case of systematized keratotic nevus which is a peculiar form of epidermal nevus is reported. The present case is rare because of the dysfunction of incomplete flexion of fingers by systematized keratotic nevus. Furthermore, it involved mixed clinical and histological changes of epidermal nevus from fingers to elbow. An operation with full-thickness skin graft was undertaken.
Pages: 255-257
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Stucco keratoses. A clinico-pathological study.
Shall L, Marks R
Stucco keratoses are benign acquired papular warty lesions which usually occur on the distal parts of the lower limbs of elderly men. Their nature and pathogenesis are uncertain. Eight patients with multiple stucco keratoses who presented to the Cardiff Dermatology Department over an 18-month period were studied in an attempt to characterize these lesions. All subjects were male, with ages ranging ...
Pages: 258-261
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Commercial glucocorticoid formulations and skin dryness. Could it be caused by the vehicle?
Korting HC, Kerscher M, Vieluf D, Mehringer L, Megele M, Braun-Falco O
Eczema craquelé can be induced by repeated open application of a topical glucocorticoid, viz. 0.05% clobetasole 17-propionate cream. This might not be invariably due to the active component. Comparison of the skin surface roughness as assessed by profilometry and as expressed by RZDIN showed a decrease after repeated open application of 0.1% betamethasone 17-valerate cream and 0.25% prednicarbate ...
Pages: 261-263
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Immediate contact reactions to cow's milk and egg in atopic children.
Oranje AP, Aarsen RS, Mulder PG, Liefaard G
Forty children (0-5 years old), presented with immediate contact urticaria, rash and often atopic dermatitis (n = 34). Redness or urticaria around the mouth appearing after consuming cow's milk or egg, were the major complaints in all. These symptoms suggested a food-induced immediate contact reaction, which can be immune-mediated or irritative. To reinduce this reaction, a skin provocation test, ...
Pages: 263-266
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Minor skin surgery. Are prophylactic antibiotics ever needed for curettage?
Maurice PD, Parker S, Azadian BS, Cream JJ
Curettage of skin lesions was not followed by bacteraemia in 22 patients. The risk of bacterial endocarditis after curettage and other minor skin surgery is small but should not be overlooked in those with a prosthetic heart valve, a history of other cardiac surgery, a previous episode of infective endocarditis, drug addiction, diabetes, alcoholism, immunosuppression, or renal failure--especially ...
Pages: 267-268
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Increased numbers of mast cells in pemphigus vulgaris skin lesions. A histochemical study.
Levi-Schaffer F, Klapholz L, Kupietzky A, Weinrauch L, Shalit M, Okon E
We have used a histochemical technique to study mast cells (MC) in skin biopsies of 8 patients suffering from pemphigus vulgaris (PV) and from 4 control volunteers. The MC were stained for 30 min with 0.5% toluidine blue, pH 0.5, counted and then restained for 5 days under the same conditions. This staining method allows the identification of two groups of MC, one that stains promptly (30 min) and ...
Pages: 269-271
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A new staining method for visualization of keratin filaments in hair fibre cross sections.
Forslind B, Andersson M
A new method of staining the keratin filament matrix allowing a visualization of the filaments in cross section of hair fibres has been developed. It differs from previously published methods in that the hair fibres are neither fixed with OsO4 nor treated with sulfur bond breaking agents. High contrast is still obtainable in sections thicker than 60 nm.
Pages: 272-273
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Hyaluronan in basal cell carcinomas.
Wells AF, Lundin A, Michaëlsson G, Pontén F
Pages: 274-275
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