Content - Volume 72, Issue 6

All articles

Secretion of urokinase and tissue-plasminogen activator by epidermal cells in the presence of psoriatic fibroblast-conditioned medium.
Horiuchi Y, Marshall JM, Cederholm-Williams SA, Ryan TJ.
The present study examined secretion of urokinase and tissue-plasminogen activator by epidermal cells in the presence of psoriatic or uninvolved skin fibroblast-conditioned medium. Using zymographic analyses, a 54kD lysis band and a small 110kD band derived from urokinase could be detected in the harvest fluid from keratinocytes treated with both psoriatic and uninvolved fibroblast-conditioned med ...
Pages: 401-402
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The hairless mouse model for assaying the atrophogenicity of topical corticosteroids.
Woodbury R, Kligman AM.
The daily application of corticosteroids for 18 days to the dorsal skin of hairless mice resulted in loss of volume of all the cutaneous compartments. The epidermis thinned, sebaceous glands regressed, dermal thickness was reduced, horn-filled cysts shrunk, subcutaneous fat disappeared, and regression of the muscular layer occurred. The magnitude of these changes correlated strongly with the accep ...
Pages: 403-406
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Expression of loricrin in skin disorders.
Juhlin L, Magnoldo T, Darmon M.
Loricrin, the major component of the cornified envelope, is normally expressed in the granular layer of epidermis during the last steps of keratinocyte differentiation. Using an antiloricrin antiserum (A8-73), an increased expression of this envelope precursor was found in some disorders of hyperorthokeratosis (ichthyosiform erythroderma; lichen ruber), but not in others (keratodermia ichthyosis v ...
Pages: 407-409
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Adenosine deaminase activity in sera of patients with psoriasis, mycosis fungoides and adult T cell leukemia.
Koizumi H, Ohkawara A.
Adenosine deaminase activities in sera were measured in 18 psoriatic patients, 8 mycosis fungoides patients, and 9 patients with adult T cell leukemia. Adenosine deaminase activity in the sera of the psoriatic patients showed no significant increase. An elevated adenosine deaminase activity was observed in 7 of the 8 patients with mycosis fungoides and 8 of the 9 patients with adult T cell leukemi ...
Pages: 410-412
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Localized proliferative effect of preadipocytes on cultured human epidermal keratinocytes.
Miyashita M, Baba S, Suzuki H.
The effect of preadipocytes (ST 13) on cultured normal human epidermal keratinocytes (NHEK) was investigated. The growth of NHEK was accelerated with co-cultured ST 13 cells. This stimulative effect must have been localized around viable ST 13 cells, because neither the medium nor the surface conditioned by ST 13 or the ST 13 cell fragments showed any promotion of NHEK growth, and NHEK showed a co ...
Pages: 413-417
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Lifetime topical application of tretinoin to hairless mice.
Kligman LH, Mezick JA, Capetola RJ, Thorne EG.
The discovery that topical tretinoin can reverse some of the effects of photodamage may lead to its chronic application. Examination of long-term effects was of interest. Three groups of hairless mice (age 6-8 weeks) were treated dorsally with 1) tretinoin (0.025%), 2) cream vehicle, 3) sham treatment. Applications were 3 times weekly and continued for up to 2 years until all mice were sacrificed ...
Pages: 418-422
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Topical retinoic acid treatment of photoaged skin: its effects on hyaluronan distribution in epidermis and on hyaluronan and retinoic acid in suction blister fluid.
Lundin A, Berne B, Michaëlsson G.
Topical treatment with retinoic acid (tretinoin, vitamin A acid) has been reported to partly reverse signs of photodamage. To determine whether the histochemical distribution of hyaluronan (hyaluronic acid, HYA) in the epidermis and dermis and the amounts of HYA and retinoic acid in suction blister fluid were influenced by such topical treatment, 14 subjects healthy apart from moderate photodamage ...
Pages: 423-427
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Elemental changes in guinea pig epidermis at repeated exposure to sodium lauryl sulfate.
Lindberg M, Forslind B, Sagström S, Roomans GM.
Epidermal hyperplasia is the response of the epidermis to external harmful stimuli. The control and regulation of this hyperplasia is not completely understood. It has been proposed that changes in the cellular sodium/potassium ratio are of importance in the regulation of cell proliferation. To evaluate if such a change in the elemental content of epidermal cells can be one factor to consider at i ...
Pages: 428-431
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A dose-response study of irritant reactions to sodium lauryl sulphate in patients with seborrhoeic dermatitis and atopic eczema.
Cowley NC, Farr PM.
The susceptibility of the skin of patients with seborrhoeic dermatitis to surfactant irritation was investigated and compared to that of a group of normal subjects and patients with a history of atopic eczema. Responses to six concentrations of sodium lauryl sulphate (SLS), applied to forearm skin, were assessed clinically and measured by laser Doppler flowmetry. Analysis of dose-response curves s ...
Pages: 432-435
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Cyclosporin A responsive chronic severe vesicular hand eczema.
Petersen CS, Menné T.
A patient with an otherwise recalcitrant chronic vesicular hand eczema responded with a dramatical improvement within 2 weeks of cyclosporin A (CsA) therapy 5.0 mg/kg daily. The patient was still free of eczema in spite of reducing the CsA dose to 2.5 mg/kg daily. CsA therapy was finally stopped due to a moderate increase in blood pressure, resulting in rapid recurrence of the hand eczema. The cas ...
Pages: 436-437
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Folinic acid rescue used routinely in psoriatic patients with known methotrexate "sensitivity".
Hills RJ, Ive FA.
Many combinations of methotrexate and folic or folinic acid have been used to limit the side effects of methotrexate therapy in psoriasis or psoriatic arthropathy. Methotrexate inhibits the enzyme dihydrofolate reductase and prevents the formation of DNA and RNA. Folinic acid, the 5-formyl derivative of tetrahydrofolic acid, is the active form of folic acid. We have confirmed in 5 patients that co ...
Pages: 438-440
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Intertriginous drug eruption.
Wolf R, Brenner S, Krakowski A.
Presented are two patients who developed an unusual, and as yet unreported eruption due to amoxycillin. They exhibited an eruption confined to the intertriginous areas, which mimicked intertrigo. Although drug eruption can mimic a variety of idiopathic skin diseases, intertrigo is easily distinguished from drug eruption and has not been mentioned in the differential diagnosis of this reaction. It ...
Pages: 441-442
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Juvenile generalized pustular psoriasis in a pair of monozygotic twins presenting strikingly similar clinical courses.
Takematsu H, Rokugo M, Takahashi K, Tagami H.
We describe an exceptionally rare case of juvenile generalized pustular psoriasis noted in monozygotic twins who, after developing the disease on the same day (the 48th day after birth) continued to show strikingly similar clinical features of generalized pustular psoriasis for 7 years. Not even therapeutic intervention by tonsillectomy performed at age 4 years on one of the twins, which was expec ...
Pages: 443-444
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Efficacy and skeletal side effects of two years' acitretin treatment.
Mørk NJ, Kolbenstvedt A, Austad J.
In this prospective study, 51 patients suffering from psoriasis and ichthyosis were treated with acitretin for 2 years. The average dose was 0.5 mg/kg/day. We have evaluated the efficacy and side effects, focusing on skeletal side effects. X-ray examinations were done before treatment and after 1 and 2 years. Forty-five patients completed the study. Acitretin had a good clinical effect, with 75% i ...
Pages: 445-448
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One-minute dithranol therapy in psoriasis: a placebo-controlled paired comparative study.
Jekler J, Swanbeck G.
In a double-blind left-right randomised comparison, 27 patients suffering from chronic plaque-type psoriasis vulgaris were treated for one minute with dithranol 2% ointment, Psoralon (Psoralon MT), on a selected psoriasis plaque on one half of the body and with a placebo ointment on a corresponding plaque on the other. The preparations were applied once daily for 8 weeks. Seventeen patients achiev ...
Pages: 449-450
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Aberrant cutaneous weal and flare responses in chronic urticaria.
Shall L, Saihan EM.
This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). Five minutes after each injection, the ...
Pages: 451-453
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Treatment with bifonazole shampoo for seborrhea and seborrheic dermatitis: a randomized, double-blind study.
Segal R, David M, Ingber A, Lurie R, Sandbank M.
Forty-four patients with seborrhea and seborrheic dermatitis of the scalp were treated with either bifonazole shampoo (22 patients) or the vehicle shampoo (22 patients) in a randomized, double-blind vehicle-controlled study. The patients were instructed to wash their scalps 3 times weekly for 6 weeks and were examined every 3 weeks. Responses were evaluated by clinicians using a clinical grading o ...
Pages: 454-455
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Allergic contact sensitization in an unselected Danish population. The Glostrup Allergy Study, Denmark
Nielsen NH, Menné T
The distribution of allergic contact sensitization was assessed in an unselected population, living in western Copenhagen, Denmark. Ready-to-apply patch tests comprising 23 haptens and mixtures of haptens were mailed to 793 adults, and 567 (71.5%) participated. The tests were read 2 days after application. A total of 111 positive reactions were found among 86 (15.2%) subjects. Sensitization was le ...
Pages: 456-460
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Intractable chronic furunculosis: prevention of recurrences with pentoxifylline.
Wahba-Yahav AV.
A 60-year-old HIV-negative man with known noninsulin-dependent diabetes mellitus and glucose 6-phosphate-dehydrogenase deficiency anemia suffered from chronic recurrent furunculosis since the age of 30. In recent years, his condition had become increasingly severe and the recurrences increasingly frequent. Different measures including continuous therapy with large doses of systemic antibiotics for ...
Pages: 461-462
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Treatment of prurigo nodularis, chronic prurigo and neurodermatitis circumscripta with topical capsaicin.
Tupker RA, Coenraads PJ, van der Meer JB.
No abstract available. Comment in: Treatment of lichen simplex chronicus with topical capsaicin cream. [Acta Derm Venereol. 1996]
Page: 463
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The "red face"--a warning sign of malignant melanoma?
Brenner S, Wolf R.
No abstract available.
Page: 464
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Raynaud's phenomenon and intralesional bleomycin.
de Pablo P, Aguillar A, Gallego MA.
No abstract available.
Page: 465
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