Content - Volume 73, Issue 6

Editor's choice in this issue

All articles

Speculations around the mechanism behind the action of peptide T in the healing of psoriasis: a minireview.
Johansson O, Hilliges M, Talme T, Marcusson JA, Wetterberg L.
Peptide T, the HIV envelope-derived fragment Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr, has already been used to successfully treat psoriatic patients without major side-effects. The underlying reason for the positive effect is, however, at present unknown. In the following minireview, we summarize today's knowledge regarding peptide T's interaction with other chemical messenger molecules, such as somatosta ...
Pages: 401-403
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The influence of water, glycerin, paraffin oil and ethanol on skin mechanics
Overgaard Olsen L, Jemec GB
Moisturizers and emollients do not only smooth the skin but also make it more supple. To clarify this effect, the short-term influence of tap water, paraffin oil, ethanol and glycerin on skin mechanics was studied. These substances are all common ingredients in moisturizers and emollients. Significant changes were seen already after 10 min of application. The distensibility and hysteresis (creep p ...
Pages: 404-406
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Sphingosines: antimicrobial barriers of the skin.
Bibel DJ, Aly R, Shah S, Shinefield HR.
Among the factors that control the survival of microorganisms on human stratum corneum are skin lipids, including sphingosines. Because the antibacterial spectrum of sphinganine resembles that of cell wall antibiotics, electron microscopy of sphinganine-treated and untreated S. aureus was performed; the lipid induced multiple lesions of cell wall, membrane evaginations and loss of ribosomes. Howev ...
Pages: 407-411
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GM1-gangliosidosis type 1 involving the cutaneous vascular endothelial cells in a black infant with multiple ectopic Mongolian spots.
Tang TT, Esterly NB, Lubinsky MS, Oechler HW, Harb JM, Franciosi RA.
GM1-gangliosidosis (GM1) is one of the metabolic storage diseases, of which a differential diagnosis requires an array of biochemical assays to determine the enzyme deficiency. This approach is not only time-consuming and costly but also unavailable to most hospital laboratories. However, a presumptive diagnosis of GM1 may be made on the basis of coarse facial feature, foamy endothelial cells in t ...
Pages: 412-415
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Dermatophytes and keratin in patients with hereditary palmoplantar keratoderma. A mycological study.
Gamborg Nielsen P, Faergemann J.
Fourteen patients with hereditary palmoplantar keratoderma of the Unna Thost variety were included in the study. Dermatophytosis was found in 7 of the 14 patients. Six were affected with T. rubrum and one with T. mentagrophytes. The growth pattern of dermatophytes in keratin from the patients did not differ from that of normal control individuals. Keratin from patients with hereditary palmoplantar ...
Pages: 416-418
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Altered expression of beta-2-microglobulin in basaloid proliferations overlying dermatofibromas.
Rossen K, Hou-Jensen K, Werdelin O.
The epidermis overlying 2-8% of dermatofibromas shows basaloid proliferations that are indistinguishable from superficial basal cell carcinoma. It is well established that basal cell carcinomas uniformly exhibit a strongly reduced expression of HLA class I molecules. Nineteen dermatofibromas with overlying basaloid proliferations were studied by immunohistochemistry using a monoclonal antibody aga ...
Pages: 419-421
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UV-induced alterations in skin and lymphocytes during a one-week holiday in the Canary Islands in May.
Bech-Thomsen N, Munch-Petersen B, Lundgren K, Poulsen T, Wulf HC.
The effect of solar exposure during a one-week sunbathing vacation in May at 29 degrees N latitude was investigated in 22 volunteers. The following end-points were measured before and after the holiday: skin reflectance at 507 nm, transmission of radiation from 289 nm to 448 nm through the epidermis, epidermal thickness, minimal erythema dose (MED), total white cell, neutrophil, lymphocyte, and ly ...
Pages: 422-425
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Chloroquine phosphate: a long-term follow-up of drug concentrations in skin suction blister fluid and plasma.
Sjölin-Forsberg G1, Berne B, Blixt C, Johansson M, Lindström B.
Chloroquine is known to bind strongly to melanin and is accumulated in the skin. In dermatology, the drug is mainly used to treat photosensitivity disorders, but it has also been reported to cause sun sensitivity, especially in patients with rheumatoid arthritis. In the present study the concentrations of chloroquine phosphate in plasma and skin suction blister fluid (interstitial fluid in the ski ...
Pages: 426-429
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Adenovirus 12 and dermatitis herpetiformis.
Handley J, O'Neill H, Connolly J, Burrows D.
Previous studies have shown that A-gliadin, a major gluten-derived peptide known to activate the gluten-sensitive enteropathy (GSE) of coeliac disease (CD), and the non-structural E1B peptide produced during early lytic gastrointestinal infection with human adenovirus type 12 (AD12) share an identical twelve amino acid sequence. It is suggested that immunological cross reactivity between these two ...
Pages: 430-432
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Severe infectious complications in a girl suffering from atopic dermatitis were found to be due to chronic granulomatous disease.
Jung K, Elsner J, Emmendörffer A, Bittrich A, Lohmann-Matthes ML, Roesler J.
Recently, the diagnosis of a variant form of chronic granulomatous disease (CGD) could be established in an 11-year-old girl who had been treated for atopic dermatitis for many years. In addition to severe superinfections of lesions of the skin, the following symptoms were found currently or in her history: an episode of chronic diarrhoea (suspected as lactose intolerance), an endomyocarditis, a p ...
Pages: 433-436
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Demodex-attributed rosacea-like lesions in AIDS.
Redondo Mateo J, Soto Guzmán O, Fernández Rubio E, Domínguez Franjo F.
The association between AIDS and demodicidosis has been occasionally described elsewhere. We present a new case, in a patient with post-transfusional AIDS, who had many papules and pustules localized to the upper trunk and face, in relation to zidovudine treatment.
Page: 437
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Chronic urticaria due to nickel intake.
Abeck D, Traenckner I, Steinkraus V, Vieluf D, Ring J.
A case of chronic urticaria is presented. The case of the disease was traced back to nickel intake by food as judged from type I and IV sensitization to nickel, a positive oral challenge test and long-standing, complete healing under a nickel-restrictive diet.
Pages: 438-439
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Quality of life in chronic leg ulcer patients. An assessment according to the Nottingham Health Profile
Lindholm C, Bjellerup M, Christensen OB, Zederfeldt B
Chronic leg ulcer is a disease of long duration, occurring predominantly in elderly people. Traditionally, little interest has been devoted to the study of the impact of this disease on life quality. In the present study the Nottingham Health Profile (NHP) was used to assess disease influence on six areas of daily life, namely: pain, physical mobility, sleep, energy, emotional reactions and social ...
Pages: 440-443
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Malignant aneuploid spindle-cell transformation in a proliferating trichilemmal tumour.
Alvarez-Quiñones M, Garijo MF, Fernández F, Val-Bernal JF.
A case of spindle-cell carcinoma developed on a proliferating trichilemmal tumour (PTT) is presented. The tumour on the scalp of an 84-year-old white woman was excised and histological examination showed typical features of PTT, but with a coexistent malignant spindle-cell tumour with a sarcomatoid appearance. There were some areas of transition between squamous trichilemmal epithelium and the neo ...
Pages: 444-446
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Treatment of necrobiosis lipoidica diabeticorum by hyperbaric oxygen.
Weisz G, Ramon Y, Waisman D, Melamed Y.
Necrobiosis lipoidica diabeticorum is a chronic cutaneous complication of diabetes mellitus with microangiopathy as an important pathophysiologic factor. Because of the known success of hyperbaric oxygen in the treatment of chronic non-healing wounds, we used this mode of therapy to treat a diabetic patient with ulcerated necrobiosis lipoidica of 7 years' duration, refractory to medical and surgic ...
Pages: 447-448
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Treatment of scleroderma with oral 1,25-dihydroxyvitamin D3: evaluation of skin involvement using non-invasive techniques. Results of an open prospective trial.
Humbert P, Dupond JL, Agache P, Laurent R, Rochefort A, Drobacheff C, de Wazieres B, Aubin F.
1,25-dihydroxycholecalciferol (1,25 (OH)2 D3) causes dose-dependent inhibition of fibroblast growth and collagen synthesis and has numerous immunoregulatory activities. We assessed the effects of oral 1,25 (OH)2 D3 in the treatment of patients with systemic sclerosis (SS). Eleven patients with SS entered an open prospective study. Oral 1,25(OH)2 D3 was given at a mean dose of 1.75 micrograms/day. ...
Pages: 449-451
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Systemic corticosteroid and isotretinoin treatment in cystic acne.
Karvonen SL, Vaalasti A, Kautiainen H, Reunala T.
Prednisolone combined with erythromycin was given to 6 patients with cystic acne. The treatment responses were compared to those in 6 patients with cystic acne receiving isotretinoin and erythromycin and also to those in 3 patients with acne fulminans treated with prednisolone and erythromycin. During the first 4 weeks cystic acne showed a clear improvement in 5 out of 6 patients in both treatment ...
Pages: 452-455
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Duration of analgesia following application of eutectic mixture of local anaesthetics (EMLA) on genital mucosa.
van der Burght M, Schønemann NK, Laursen JK, Arendt-Nielsen L, Bjerring P.
The topical anaesthetic formulation EMLA cream (eutectic mixture of local anaesthetics) is increasingly used prior to minor painful procedures performed on genital mucosa. The aim of the present study was to gain knowledge about the correlation between duration of application of EMLA and duration of analgesia. Three different application times--5, 10 and 20 min--were investigated in 12 healthy you ...
Pages: 456-458
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Symmetrical interdigital hyperkeratosis of the hands: a new case.
Patrizi A, Neri I, Di Lernia V, Varotti C.
Congenital symmetrical interdigital hyperkeratosis is a rare disorder described by Frei in 1923, characterized by localized hyperkeratosis of the interdigital spaces of the hands and feet. The authors report the case of a 7-year-old girl affected by this condition. The skin hyperkeratotic lesions appeared localized exclusively to the interdigital spaces of the hands. Histologic examination showed ...
Pages: 459-460
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Localized atypical pemphigoid on lymphoedema following radiotherapy.
Callens A, Vaillant L, Machet MC, Arbeille B, Machet L, De Muret A, Sizaret PY, Lorette G.
Autoimmune bullous diseases have been reported associated with different causal factors: drugs, mechanical trauma and physical trauma, particularly ultraviolet light and radiotherapy. In these cases different hypotheses regarding the pathogenesis of blister formation can be supported. In this observation, we report a localized cicatricial pemphigoid with unusual clinical presentation. Moreover, it ...
Pages: 461-464
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Ano-genital warts in consecutive male heterosexual patients referred to a CO2-laser clinic in Copenhagen.
Sand Petersen C, Menné T.
The relation between sexual practices and location of anogenital warts is discussed. Results were derived from clinical examination and interview of 56 consecutive male patients referred to CO2-laser treatment of therapy-resistant genital warts, at a clinic at the Department of Dermatovenereology, Gentofte Hospital, located in the northern area of Copenhagen. Twenty (100%) patients with anal warts ...
Pages: 465-466
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Topical delivery of acetazolamide for psoriasis.
Olafsson JH, Loftsson T, Fridriksdóttir H.
No abstract available.
Page: 467
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