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Content - Volume 75, Issue 1

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INVESTIGATIVE REPORT
Increased chemiluminescence of whole blood and normal T-lymphocyte subsets in severe nodular acne and acne fulminans.
Karvonen SL, Räsänen L, Soppi E, Hyöty H, Lehtinen M, Reunala T
To investigate the inflammatory and immunological aspects of severe acne, we examined the luminol-enhanced chemiluminescence of whole blood, T-cell subsets and natural killer cell functions in 11 patients with severe nodular acne and 4 patients with acne fulminans. In patients with severe nodular acne, the active phase of the disease, compared to the values in remission (means 47 mV, SD 24.8 and 3 ...
Pages: 1-5
Abstract  PDF
INVESTIGATIVE REPORT
Epidermal regeneration and occlusion
van de Kerkhof PC, de Mare S, Arnold WP, van Erp PE
Disruption of the stratum corneum, by tape stripping or chemical injury, results in epidermal recovery of the skin barrier. In human skin, 40-48 h after surface trauma, epidermal proliferation is maximal. In a previous study in mice, occlusion with plastic or the hydrocolloid Duoderm proved to inhibit the regenerative response. The aim of the present investigation was to find out whether occlusion ...
Pages: 6-8
Abstract  PDF
INVESTIGATIVE REPORT
Increased concentration of beta-endorphin in the sera of patients with severe atopic dermatitis.
Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D
Serum beta-endorphin was measured by radioimmunoassay in 25 patients with atopic dermatitis and 100 healthy subjects. The neuropeptide was found to be markedly (p < 0.001) increased in patients with atopic dermatitis (9.2 +/- 3.4 pg/ml) as compared to normal controls (6.1 +/- 1.5 pg/ml). A correlation between increased serum beta-endorphin concentration and some clinical parameters of the disease ...
Pages: 9-11
Abstract  PDF
INVESTIGATIVE REPORT
Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris.
Matzner Y, Erlich HA, Brautbar C, Sanilevitch A, Landau M, Brenner S, Friedmann A
In pemphigus vulgaris, a dermatological autoimmune disease, specific human leukocyte antigen (HLA) class II alleles, DR4 (DRB1*0402) and DRw14 (DRB1*1401, in linkage disequilibrium with DQB1*0503), are thought to be susceptibility genes involved in the onset of the disease. We studied the HLA class II alleles (DQA1, DQB1, DRB1 and DPB1) of 6 patients with pemphigus, in whom the disease was "trigge ...
Pages: 12-14
Abstract  PDF
INVESTIGATIVE REPORT
Microcirculatory segments identified with monoclonal antibody against alpha-smooth muscle actin: comparison between Kimura's disease and angiolymphoid hyperplasia with eosinophilia.
Katoh N, Hirano S, Kishimoto S, Yasuno H
Microcirculatory systems, which can be divided into several segments, have crucial physiological functions. We investigated whether monoclonal antibody against alpha-smooth muscle actin (alpha SMA) was useful for the identification of microcirculatory segments, according to the structure of their periendothelial cells, in two pathological cutaneous conditions. We examined skin specimens from patie ...
Pages: 15-18
Abstract  PDF
INVESTIGATIVE REPORT
Protective effect of zinc on keratinocyte activation markers induced by interferon or nickel.
Guéniche A, Viac J, Lizard G, Charveron M, Schmitt D
Zinc therapies exert beneficial effects in several cutaneous pathologies through their antiinflammatory properties, but target cells and mechanisms of action are still uncertain. We wondered whether markers of the keratinocyte activation state, such as the expression of immune surface antigens (ICAM-1 and HLA-DR) and the production of TNF-alpha, frequently detected in inflammatory reactions, may b ...
Pages: 19-23
Abstract  PDF
INVESTIGATIVE REPORT
The microbial flora in venous leg ulcers without clinical signs of infection. Repeated culture using a validated standardised microbiological technique.
Hansson C, Hoborn J, Möller A, Swanbeck G
The change of ulcer size in relation to the presence of species and quantities of microorganisms was analysed in 58 patients with venous leg ulcers, all without clinical signs of infection. Microbiological samples were taken on the day of inclusion and then repeated 4 times at monthly intervals or until the ulcer had healed or was too small to be cultured from. There was growth of microorganisms i ...
Pages: 24-30
Abstract  PDF
INVESTIGATIVE REPORT
The effect of antiseptic solutions on microorganisms in venous leg ulcers.
Hansson C, Faergemann J
The effect on the microbial ulcer flora of wet gauze dressings soaked in antiseptic solutions used for desloughing leg ulcers is not known. Quantitative cultures were therefore performed in 45 venous leg ulcers, before application and after 15 minutes' treatment with gauze dressings with four different antiseptic solutions: aluminium acetotartrate (Alsol) 1%, potassium permanganate 0.015%, acetic ...
Pages: 31-33
Abstract  PDF
INVESTIGATIVE REPORT
Oxidative activation of the propolis hapten isoprenyl caffeate.
Hansson C, Ezzelarab M, Sterner O
The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being fou ...
Pages: 34-36
Abstract  PDF
INVESTIGATIVE REPORT
Innervation of the skin of the forearm in diabetic patients: relation to nerve function.
Wallengren J, Badendick K, Sundler F, Håkanson R, Zander E
Complications of diabetes include sensory and autonomic neuropathy. The aim of the present paper was to study the degree of sensory and autonomic neuropathy and correlate these findings with the distribution and density of neuropeptidergic nerve fibers in the skin of the forearm of diabetic patients and healthy controls. We investigated 30 diabetics (24 type 1 and 6 type 2) and compared them with ...
Pages: 37-42
Abstract  PDF
CLINICAL REPORT
Low dose versus medium dose UV-A1 treatment in severe atopic eczema.
Kowalzick L, Kleinheinz A, Weichenthal M, Neuber K, Köhler I, Grosch J, Lungwitz G, Seegeberg C, Ring J
Twenty-two patients with severe atopic eczema were included in a therapy study with UV-A1 (wavelengths > 340 nm) treatment. The patients were divided into two dose groups, each consisting of 11 patients. One group received 10 J/cm2 and the other 50 J/cm2 five times a week for 3 consecutive weeks. No topical or systemical steroids or antihistamines were allowed. Using the SCORAD index as a measure ...
Pages: 43-45
Abstract  PDF
Topical antimycotic treatment of atopic dermatitis in the head/neck area. A double-blind randomised study
Broberg A, Faergemann J.
In order for us to evaluate the effect of topical antimycotic treatment in patients with atopic dermatitis affecting the head and neck area, 60 patients (36 females and 24 males; median age 28 years; range 14-53 years) were included in a double-blind study during 6 weeks. Of the 53 evaluable patients, 55% had positive skin prick tests to Pityrosporum ovale. In addition to oral antibiotic treatment ...
Pages: 46-49
Abstract  PDF
CLINICAL REPORT
Prevalence and some clinical aspects of atopic dermatitis in the community of Sør-Varanger.
Dotterud LK, Kvammen B, Lund E, Falk ES
A study of the prevalence of atopic dermatitis among 7-12-year-old children was carried out in a rural community in Northern Norway close to the Russian border. Of the 424 children investigated, 37% had a past and/or present history of atopic dermatitis (cumulative incidence), whereas 23% were classified as having atopic dermatitis by clinical examination (point prevalence). A history of atopic de ...
Pages: 50-53
Abstract  PDF
CLINICAL REPORT
Urticarial vasculitis syndrome effectively treated with dapsone and pentoxifylline.
Nürnberg W, Grabbe J, Czarnetzki BM
Urticarial vasculitis is difficult to treat. We report here on a 40-year-old woman with a 16-year history of idiopathic hypocomplementemic urticarial vasculitis syndrome. Her disease had been resistant to treatment with H1- and H2-blockers, indomethacin, dapsone and interferon alpha but responded to > 25 mg/day prednisolone. Monotherapy with pentoxifylline was also of only minor benefit. Using a c ...
Pages: 54-56
Abstract  PDF
CLINICAL REPORT
Cutaneous adverse reactions after intra-articular injection of triamcinolone acetonide.
Ijsselmuiden OE, Knegt-Junk KJ, van Wijk RG, van Joost T
A patient is described with a disseminated morbilliform and partially persistent urticarial dermatitis following intra-articular injections of triamcinolone acetonide. A delayed-type hypersensitivity to triamcinolone acetonide was observed after patch and intradermal testing. However, an immediate-type hypersensitivity to this drug was not observed. A delayed-type sensitization to betamethasone, d ...
Pages: 57-58
Abstract  PDF
CLINICAL REPORT
Protein-losing enteropathy in a child with junctional epidermolysis bullosa and pyloric atresia.
Meldgaard Lund A, Karlsmark T, Kobayasi T
We report on a newborn boy with junctional epidermolysis bullosa and pyloric atresia. Blisters were found on his skin at birth, especially in places exposed to pressure, and appeared later on his mucous membranes. Epidermolysis bullosa was confirmed by electron microscopy. Radiography revealed pyloric atresia, and a gastroduodenostomy was carried out at 7 days of age. A connective tissue septum wa ...
Pages: 59-61
Abstract  PDF
CLINICAL REPORT
Langerhans' cell histiocytosis: complete remission after oral isotretinoin therapy.
Tsambaos D, Georgiou S, Kapranos N, Monastirli A, Stratigos A, Berger H
Pages: 62-64
Abstract  PDF
CLINICAL REPORT
Remission of ordinary psoriasis following a short clearance course of cyclosporin.
Levell NJ, Shuster S, Munro CS, Friedmann PS
We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day (30 patients) or topical dithranol and ultraviolet B therapy (30 patients) for u ...
Pages: 65-69
Abstract  PDF
CLINICAL REPORT
Metabolic carotenemia and carotenoderma in a child
Svensson A, Vahlquist A
We describe a 3-year-old girl with long-standing yellow discoloration of her skin and a 3-fold increase in the plasma carotenoid concentration compared to normal, but no history of excessive carotene intake or familial carotenemia. When put on a carotene-deficient diet for 8 months she still had some remaining yellow discoloration in the nasolabial folds and on the palms and soles. The results of ...
Pages: 70-71
Abstract  PDF
CLINICAL REPORT
Photosensitivity dermatitis/actinic reticuloid syndrome in an Irish population: a review and some unusual features.
Healy E, Rogers S
Nine patients with photosensitivity dermatitis and actinic reticuloid syndrome are reported. The rash affected light-exposed skin only in 7 patients and extended to covered sites in 2. Seven were sensitive to UVB, UVA and visible light, one to UVA and one to visible light only. Two patients had significant clinical improvement in spite of both having suffered severe disease previously. Another pat ...
Pages: 72-74
Abstract  PDF
CLINICAL REPORT
Human papilloma virus infection among women attending an STD clinic correlated to reason for attending, presence of clinical signs, concomitant infections and abnormal cytology.
Voog E, Bolmstedt A, Olofsson S, Ryd W, Löwhagen GB
The purpose of this study was to demonstrate the prevalence of cervical human papilloma virus (HPV) infection correlated to reason for attending an STD clinic, presence of clinical signs of HPV infection, concomitant infection and abnormal cytology. Samples from the cervical canals of 588 consecutive women attending the STD clinic, Department of Dermato-Venereology, Sahlgrenska Hospital, Gothenbur ...
Pages: 75-78
Abstract  PDF
LETTER TO THE EDITOR
Lymphangioma circumscriptum of the vulva of late onset.
Cecchi R, Bartoli L, Brunetti L, Pavesi M, Giomi A
Pages: 79-80
Abstract  PDF
LETTER TO THE EDITOR
Natural alpha interferon in chronic actinic dermatitis. Report of a case.
Parodi A, Gallo R, Guarrera M, Rebora A
Pages: 80-80
Abstract  PDF
LETTER TO THE EDITOR
Possible aggravation of hepatitis A by acitretin.
Krüger-Krasagakes S, Grabbe J, Czarnetzki BM
Pages: 82-83
Abstract  PDF
LETTER TO THE EDITOR
Tuberculosis cutis orificialis: an association with Evans' syndrome.
Kim SW, Choi SW, Cho BK, Houh W, Lee JW
Pages: 84-85
Abstract  PDF
LETTER TO THE EDITOR
Generalized lichen planus associated with primary biliar cirrhosis which resolved after liver transplantation.
Oleaga JM, Gardeazabal J, Sanz de Galdeano C, Diaz PJ
Pages: 87-87
Abstract  PDF
LETTER TO THE EDITOR
Urinary albumin excretion in patients with uncomplicated diffuse psoriasis.
Utas S, Utas C, Kelestimur F, Bas K, Sahin S, Pasaoglu H, Soyuer U
Pages: 88-88
Abstract  PDF
LETTER TO THE EDITOR
Treatment of generalized bullous pemphigoid with topical corticosteroids.
Spuls PI, Brakman M, Westerhof W, Bos JD
Pages: 89-89
Abstract  PDF
LETTER TO THE EDITOR
A therapeutic study of nail psoriasis using electron beams.
Kwang TY, Nee TS, Seng KT
Pages: 90-90
Abstract  PDF
LETTER TO THE EDITOR
TEWL measurement standardization.
Serup J
Pages: 91-92
Abstract  PDF