Content

Content - Volume 75, Issue 2

Editor's choice in this issue

All articles

INVESTIGATIVE REPORT
Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function.
Seidenari S, Pepe P, Di Nardo A.
Sodium hydroxide-induced irritation was studied in 34 volunteers, by means of 24-h patch testing at different concentrations, and by a 10-min testing procedure employing 0.1 mol/l NaOH. As a supplement to subjective evaluation of skin changes, assessments of test areas by TEWL measurement and sonography were performed at 24, 48 and 72 h. After 24-h patch testing, instrumental evaluations showed an ...
Pages: 97-101
Abstract  PDF
INVESTIGATIVE REPORT
Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars.
Nakaoka H, Miyauchi S, Miki Y
Monoclonal antibodies were used to demonstrate proliferating cell nuclear antigen (PCNA) and Ki-67 antigen of dermal fibroblasts in formalin-fixed, paraffin-embedded tissue sections of keloids, hypertrophic scars and normal skin. PCNA-stained fibroblasts were more pronounced than Ki-67, which showed only scanty Ki-67-positive fibroblasts. The mean density of dermal fibroblasts was significantly hi ...
Pages: 102-104
Abstract  PDF
INVESTIGATIVE REPORT
Hydrolysis of fatty acid esters by Malassezia furfur: different utilization depending on alcohol moiety.
Mayser P, Führer D, Schmidt R, Gründer K
The lipophilic yeast Malassezia furfur belongs to the resident skin flora but has been implicated in various skin diseases. While topical oily preparations may support its growth, their formulation may be altered by yeast-dependent enzymatic degradation. Different synthetic fatty acid (mono-)esters used as refatting agents were mixed with 10(4), 10(5) and 5 x 10(5) yeasts/microliters, respectively ...
Pages: 105-109
Abstract  PDF
INVESTIGATIVE REPORT
Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis.
Kuijpers AL, Alkemade HA, Schalkwijk J, van de Kerkhof PC
We have assessed the distribution pattern of a new epidermal elastase inhibitor, skin-derived antileukoproteinase (SKALP) and polymorphonuclear leukocytes (PMN) in a patient with annular pustular psoriasis, using immunohistochemical methods. In clinically uninvolved skin SKALP was not expressed and only occasionally a few PMN could be identified. In the erythematous distal margin of the lesion, ex ...
Pages: 111-113
Abstract  PDF
INVESTIGATIVE REPORT
Percutaneous absorption of organic solvents during intermittent exposure in guinea pigs.
Boman A, Hagelthorn G, Magnusson K
Skin absorption under intermittent exposure of guinea pigs to n-butanol, toluene, 1,1,1-trichloroethane was studied. Groups of guinea pigs were exposed to test organic solvents for 1 min at 30-min intervals during 4 h, in all 8 exposures. Skin absorption of solvent was assessed by following the concentration of solvent in the blood. This intermittent exposure was compared to continuous exposure ov ...
Pages: 114-119
Abstract  PDF
INVESTIGATIVE REPORT
Dermal oedema in lipodermatosclerosis: distribution, effects of posture and compressive theraphy evaluated by high-frequency ultrasonography.
Gniadecka M
Although leg oedema is believed to contribute to the pathogenesis of lipodermatosclerosis and leg ulcer, little is known about the cutaneous distribution of water in lipodermatosclerosis. In lipodermatosclerosis accompanied by leg ulceration, a subepidermal low echogenic band is seen in the high-frequency echograms of the skin at the boundary of the wound. Since skin echogenicity is inversely rela ...
Pages: 120-124
Abstract  PDF
CLINICAL REPORT
Henoch-Schönlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis
Helander SD, De Castro FR, Gibson LE
Significant cutaneous vascular IgA deposits are common in Henoch-Schönlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Schönlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 92 cases with IgA vascular deposits and a direct immunofluorescence impression o ...
Pages: 125-129
Abstract  PDF
CLINICAL REPORT
Selective increase of IgA rheumatoid factor in patients with gluten sensitivity.
Sökjer M, Jónsson T, Bödvarsson S, Jónsdóttir I, Valdimarsson H.
An increased prevalence of raised autoantibodies, including rheumatoid factor, has been reported in patients with gluten sensitivity. However, rheumatoid factor has only been measured in small groups of patients and the findings have been conflicting. In this study IgM, IgG and IgA rheumatoid factor was measured in 89 patients with dermatitis herpetiformis and 22 patients with coeliac disease and ...
Pages: 130-132
Abstract  PDF
CLINICAL REPORT
Leg ulcers: report on a multidisciplinary approach.
Akesson H, Bjellerup M
In a Swedish survey, leg ulcer disease has been found to have a prevalence of around 1%. The multifactorial etiology requires a multidisciplinary approach. Forty-three patients with leg ulcers have been examined clinically and by pathophysiological and roentgenological investigations. Proper conservative treatment was instituted in 25 of the patients, and the remaining were treated by venous surge ...
Pages: 133-135
Abstract  PDF
CLINICAL REPORT
Life expectancy, mortality and prognostic factors in neurofibromatosis type 1. A twelve-year follow-up of an epidemiological study in Göteborg, Sweden
Zöller M, Rembeck B, Akesson HO, Angervall L
Neurofibromatosis type 1 (NF1) is a genetic disease with an extremely wide range of manifestations. As yet, the individual course of NF1 cannot be predicted, and it is uncertain to what extent the disorder is associated with increased mortality. In order to gain insights into these aspects, we have conducted a 12-year follow-up study of 70 adult NF1 patients in the city of Göteborg, Sweden, where ...
Pages: 136-140
Abstract  PDF
CLINICAL REPORT
Diffuse partial woolly hair.
Guidetti MS, Fanti PA, Piraccini BM, Barbareschi M, Tosti A
We report here a 14-year-old girl with diffuse partial woolly hair. The patient presented mild hair loss associated with the presence of fine, short and kinky hairs closely interspersed with the normal hair throughout the scalp. The pathology of the scalp revealed the presence of intermediate-sized hair follicles regularly intermingled with normal follicles in each follicular unit. The possibility ...
Pages: 141-142
Abstract  PDF
CLINICAL REPORT
Fatal vascular involvement in systemic lupus erythematosus following epidermolysis bullosa acquisita.
Yoon J, Moon TK, Lee KH, Kim SC
Epidermolysis bullosa acquisita may be associated with various systemic diseases, including systemic lupus erythematosus. We describe the clinical and immunological findings in a 38-year-old women with epidermolysis bullosa acquisita and systemic lupus erythematosus. The epidermolysis bullosa acquisita preceded a dramatic flare of systemic lupus erythematosus and fatal cerebral vasculitis. If sero ...
Pages: 143-146
Abstract  PDF
CLINICAL REPORT
Efficacy of cetirizine in cholinergic urticaria.
Zuberbier T, Aberer W, Burtin B, Rihoux JP, Czarnetzki BM
In order to examine the efficacy of cetirizine in cholinergic urticaria, we studied 24 patients in a double-blind crossover design during 3-week treatment periods, with either 10 or 20 mg/d cetirizine or placebo. The placebo period was always placed in between the two verum treatments to allow for a washout of the drug. Evaluation of the patients' daily symptom scores based on itching, erythema an ...
Pages: 147-149
Abstract  PDF
CLINICAL REPORT
The steroid-sparing effect of long-term plasmapheresis in pemphigus
Søndergaard K, Carstens J, Jørgensen J, Zachariae H.
Glucocorticoids and immunosuppressive agents can induce remission in most patients with pemphigus, but mortality remains at 5 to 15% due to complications from these drugs. We reviewed the adjunctive effect of long-term plasmapheresis in 8 patients with pemphigus. Four cases had been resistant to conventional therapy. One or two large-volume plasmapheresis treatments were given monthly for 5 to 73 ...
Pages: 150-152
Abstract  PDF
CLINICAL REPORT
The prozone phenomenon in secondary syphilis.
Taniguchi S, Osato K, Hamada T
We describe a 37-year-old woman with secondary syphilis, in whom the prozone phenomenon (false-negative test in undiluted specimens) occurred. The patient had been maintained on cyclosporine and prednisolone after renal transplantation. B-cell dysfunction induced by continuous immunosuppression may lead to higher non-treponemal serological titers. Non-treponemal testing should be repeated using se ...
Pages: 153-154
Abstract  PDF
LETTER TO THE EDITOR
A patient with an unusual localization of recurrent erythema multiforme.
de Jong EM, Koopman RJ, van de Kerkhof PC
Pages: 155-156
Abstract  PDF
LETTER TO THE EDITOR
Plantar psoriasis: clinical correlation of lesion pattern to weight bearing.
Kumar B, Kaur I, Thami GP
Pages: 157-158
Abstract  PDF
LETTER TO THE EDITOR
Mucosal hyperpigmentation due to oxabolone.
Drago F, Gelati G, Battifoglio ML, Rebora A
Pages: 158-158
Abstract  PDF
LETTER TO THE EDITOR
Transepithelial elimination in cutaneous leishmaniasis.
Azadeh B, Abdulla F
Pages: 159-159
Abstract  PDF
LETTER TO THE EDITOR
Cholesterol crystal embolization presenting as erythema induratum of bazin.
Rodot S, Lacour JP, Van Elslande L, Perrin C, Castanet J, Ortonne JP
Pages: 160-161
Abstract  PDF
LETTER TO THE EDITOR
Persistent nodular lesions caused by "bee-sting therapy".
Veraldi S, Raiteri F, Caputo R, Alessi E
Pages: 161-162
Abstract  PDF
LETTER TO THE EDITOR
Follicular mycosis fungoides--augmentation by PUVA therapy.
Germing H, Hölzle E, Schulte-Huermann P, Ruzicka T
Pages: 164-165
Abstract  PDF
LETTER TO THE EDITOR
Cutaneous lesions as the first sign of disseminated mucormycosis.
Peñas PF, Rios L, de la Cámara R, Fraga J, Daudén E
Pages: 166-167
Abstract  PDF
LETTER TO THE EDITOR
The number of mast cells is highly increased in non-involved skin in psoriasis.
Michaëlsson G, Hagforsen E, Lundin IP
Pages: 169-169
Abstract  PDF
LETTER TO THE EDITOR
Scanning electron microscopy in the diagnosis of pili multigemini.
Cambiaghi S, Barbareschi M, Cambiaghi G, Caputo R
Pages: 170-171
Abstract  PDF
LETTER TO THE EDITOR
Pemphigus in pregnancy.
Virgili A, Corazza M, Vesce F, Garutti P, Mollica G, Califano A
Pages: 172-173
Abstract  PDF