Content

Content - Volume 75, Issue 3

Editor's choice in this issue

All articles

INVESTIGATIVE REPORT
Immunohistochemical detection of p53 protein expression in HPV-induced condyloma acuminatum.
Tendler Y, Schwartz Y, Reshef R, Shasha SM, Rotter V, Shkolnik T
Immunohistochemical peroxidase staining for p53 protein was performed on 22 condyloma acuminatum tissue samples from patients infected with human papillomavirus (HPV). The purpose of our study was to understand the benign character of this syndrome. The patients studied were infected by HPV type 6 and 11. Two monoclonal antibodies, PAbs DO-1 and 240, were used to detect the p53 protein. Overexpres ...
Pages: 177-179
Abstract  PDF
INVESTIGATIVE REPORT
Relation of p53 tumor suppressor protein expression to human papillomavirus (HPV) DNA and to cellular atypia in male genital warts and in premalignant lesions.
Ranki A, Lassus J, Niemi KM
Functional disturbance of p53 tumor suppressor protein contributes to uncontrolled cell growth. Human papillomavirus (HPV) E6 oncoproteins bind to wild-type p53 and abrogate its function. Our objective was to elucidate the relation of aberrant p53 protein expression to HPV DNA and cellular atypia in male genital warts and premalignant lesions. Immunohistochemically detectable p53 protein expressio ...
Pages: 180-186
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INVESTIGATIVE REPORT
Immunohistochemical detection of p53 in epidermal proliferations overlying dermatofibromas.
Haerslev T, Rossen K, Hou-Jensen K, Jacobsen GK
Basaloid proliferations of epidermis overlying dermatofibromas and morphologically resembling superficial basal cell carcinomas might possess a malignant potential. In order to elucidate whether these basaloid proliferations share phenotypic characteristics with malignancy, we examined immunohistochemically 19 cases of dermatofibroma with overlying epidermal basaloid proliferations, 10 dermatofibr ...
Pages: 187-189
Abstract  PDF
INVESTIGATIVE REPORT
Expression of transglutaminase I in human anagen hair follicles.
Tamada Y, Takama H, Kitamura T, Ikeya T, Yokochi T
The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining became translocated to the inner site of the outer root sheath in the middle par ...
Pages: 190-192
Abstract  PDF
INVESTIGATIVE REPORT
Interferometry: a new method for no-touch measurement of the surface and volume of ulcerous skin lesions.
Altmeyer P, Erbler H, Krömer T, Duwe HP, Hoffmann K
A new interferometry procedure (Holon View measuring system) permits non-invasive and objective measurement of the surface, height/depth and volume of ulcerous lesions. The method, which uses a combination of the so-called phase-shift and gray-code technique, is new in dermatology. The measuring system consists of a diffraction grating projection system, a video camera and a computer-aided, digita ...
Pages: 193-197
Abstract  PDF
INVESTIGATIVE REPORT
Effect of systemic treatment with cholesterol-lowering drugs on the skin barrier function in humans
Ramsing D, Agner E, Malinowski J, Meibom J, Agner T
The intercellular lipids of stratum corneum are predominantly formed by cholesterol, ceramides and free fatty acids. Cholesterol synthesis is inhibited by statins, cholesterol-lowering drugs (lovastatin, pravastatin, simvastatin). The present study was undertaken to examine the effect of these drugs on skin barrier function. Knowledge about the effect on epidermis of systemic inhibition of cholest ...
Pages: 198-201
Abstract  PDF
INVESTIGATIVE REPORT
Skin barrier properties in patients with recessive X-linked ichthyosis.
Johansen JD, Ramsing D, Vejlsgaard G, Agner T.
Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin response to SLS were studied by measurement of transepidermal water loss (TEWL), ...
Pages: 202-204
Abstract  PDF
INVESTIGATIVE REPORT
Photoirritation: a new photobiologic phenomenon induced by long wavelength UVA radiation in hairless mice treated with broad-spectrum sunscreens.
Kligman LH, Zheng P, Kligman AM.
While assessing the protective effect of broad-spectrum sunscreens against chronic UVA radiation, we observed a paradoxical worsening of skin damage with one product. To further examine this finding, five proprietory broad-spectrum sunscreens were applied to albino hairless mice irradiated thrice weekly for 32 weeks with a UVASUN lamp (> 340 nm). Appropriate age-matched controls were included. Aft ...
Pages: 205-211
Abstract  PDF
INVESTIGATIVE REPORT
A simple method for measuring the amount of immunoglobulin A secreted onto the skin surface
Imayama S, Shimozono Y, Urabe A, Hori Y
We developed a simple method for measuring the amount of the secretory form of immunoglobulin A (sIgA) present in sweat. A small disk (10 x 10 mm) made of cellulose membrane was attached to the skin surface for periods of 1 to 24 h. SIgA was absorbed to the membrane and accumulated during the period of application. Enzyme immunoassay using anti-sIgA and antisecretory component (SC) antibodies reve ...
Pages: 212-217
Abstract  PDF
INVESTIGATIVE REPORT
In vitro T cell response to staphylococcal enterotoxin B superantigen in chronic plaque type psoriasis.
Bour H, Demidem A, Garrigue JL, Krasteva M, Schmitt D, Claudy A, Nicolas JF
Recent studies have demonstrated the important role of CD4+ T cells in the pathophysiology of psoriasis. One of the current hypotheses is that triggering of the psoriatic inflammatory process could be secondary to CD4+ T cell activation by bacterial superantigens in the skin. In this study, IL-2-derived T cell lines were recovered from the blood and the skin of 4 patients with chronic plaque type ...
Pages: 218-221
Abstract  PDF
INVESTIGATIVE REPORT
Ultrastructure of murine epidermis treated with the vitamin D3 analogue KH-1060.
Kobayasi T, Gniadecki R, Serup J.
A new highly potent analogue (KH-1060) of vitamin D3 has been recently shown to stimulate the growth and differentiation of keratinocytes. This study was intended to determine the effects of this new analogue on epidermis at the ultrastructural level. KH-1060 was applied topically on the backs of hairless mice for 4 weeks; the skin was then studied by routine electron microscopy. The effects were ...
Pages: 222-227
Abstract  PDF
INVESTIGATIVE REPORT
In situ localization of chloroquine and immunohistological studies in UVB-irradiated skin of photosensitive patients.
Sjölin-Forsberg G, Berne B, Eggelte TA, Karlsson-Parra A
Chloroquine can prevent photosensitivity reactions, but its mechanism of action is poorly understood. To investigate if the drug may interfere with inflammatory or immunological mechanisms of the UV-induced erythema of photosensitive patients, we studied the localization of chloroquine in the skin and its effect on the epidermal/dermal expression of IL-1, TNF-alpha, IL-6 and ICAM-1 and the occurre ...
Pages: 228-231
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Provocation of porphyria cutanea tarda by KUVA-therapy of vitiligo
Jansen T, Megahed M, Hölzle E, Plewig G.
Therapy with khellin and UVA irradiation (KUVA) is a therapeutic approach to vitiligo. Little is known about the photobiological properties of khellin and its long-term side-effects after prolonged administration. A 47-year-old woman suffering from acral vitiligo since the age of 3 is reported, who developed blisters on hands and fingers during KUVA-therapy. Laboratory findings were consistent wit ...
Pages: 232-233
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CLINICAL REPORT
Cryoglobulinemic vasculitis associated with hepatitis C virus infection. A report of eight cases
Revenga Arranz F, Díaz Díaz R, Iglesias Díez L, Cassis Herce B, Sánchez Gómez F, Fuertes Ortiz A
Cryoglobulinemia has an unknown etiology in many cases. In the last years, hepatitis C virus has been known to be involved as a causative agent of so called essential mixed cryoglobulinemia. We report 8 patients suffering from cutaneous vasculitis and chronic hepatitis C virus infection. Their sera showed cryoglobulinemia (6 cases mixed, 2 cases not typified), rheumatoid factor and complement cons ...
Pages: 234-236
Abstract  PDF
CLINICAL REPORT
Atypical mycobacterial cervical lymphadenitis associated with Sweet's syndrome
Hsiao GH, Chiu HC
We report the case of a 52-year-old woman with a non-tuberculous (atypical) mycobacterial cervical lymphadenitis, caused by Mycobacterium fortuitum, in association with Sweet's syndrome. The cervical lymphadenitis was resistant to medical treatment, and the Sweet's syndrome occurred intermittently. Systemic steroid treatment was required to control the cutaneous symptoms.
Pages: 237-239
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The Psoriasis Life Stress Inventory: a preliminary index of psoriasis-related stress
Gupta MA, Gupta AK
The psychosocial impact of psoriasis may result in significant daily stress for the patient. We present a questionnaire, the Psoriasis Life Stress Inventory (PLSI), which provides a rating of psoriasis-related stress. Two hundred and seventeen psoriasis patients endorsed a list of psoriasis-related items they had experienced over the previous one month and rated the degree of stress associated wit ...
Pages: 240-243
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LETTER TO THE EDITOR
Urticaria pigmentosa in identical male twins.
Pec J, Palencarova E, Malisova S, Dobrota D, Hajtman A, Pec M, Lepej J
Pages: 244-244
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LETTER TO THE EDITOR
A case of acute tuberculous ulcer diagnosed rapidly by the polymerase chain reaction
Ban M, Kanematsu M, Ehara H, Yanagihara M, Kitajima Y
Pages: 245-245
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LETTER TO THE EDITOR
Acanthosis palmaris: a marker of bronchogenic carcinoma
Thappá DM, Garg BR, Venkateswaran S, Sharma OP
Pages: 246-246
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LETTER TO THE EDITOR
Zinc status in patients with telogen defluvium.
Arnaud J, Beani JC, Favier AE, Amblard P
Pages: 248-249
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LETTER TO THE EDITOR
Fixed drug eruption due to cimetidine.
Inoue A, Teramae H, Hisa T, Taniguchi S, Chanoki M, Hamada T
Pages: 250-250
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LETTER TO THE EDITOR
The case of the mercury heart.
Thomson J, Holmes S
Pages: 251-251
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LETTER TO THE EDITOR
Antithrombin-III plasma levels in patients with venous leg ulcer disease
Munkvad S, Jørgensen M
Pages: 251-251
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LETTER TO THE EDITOR
Atrophia maculosa varioliformis cutis.
Nakayama H, Mihara M
Pages: 252-252
Abstract  PDF