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Content - Volume 76, Issue 3

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Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa.
Sondell B, Dyberg P, Anneroth GK, Ostman PO, Egelrud T
Stratum corneum chymotryptic enzyme (SCCE) may function in the degradation of intercellular cohesive structures in the stratum corneum preceding desquamation. Previous results have suggested that SCCE may be specifically expressed in squamous epithelia undergoing terminal differentiation and keratinization. The aim of the present work was to further elucidate the association between SCCE expressio ...
Pages: 177-181
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Effect of topical laurocapram (Azone) on the in vitro percutaneous permeation of sodium lauryl sulfate using human skin.
Szolar-Platzer C, Patil S, Maibach HI
The probability of simultaneous cutaneous exposure to surfactants and penetration enhancers could occur frequently during routine skin treatment. This study ascertains whether pre-exposure of skin to laurocapram would affect the penetration of a model surfactant, sodium lauryl sulfate (SLS). In vitro experiments with human skin were performed to compare the penetration of SLS after pretreatment wi ...
Pages: 182-185
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Skin ultrastructure after calcipotriol treatment: a transmission electron microscopic and freeze-fracture study on psoriatic patients.
Cavicchini S, Brezzi A, Gasparini G, Caputo R
Electron microscopic details in psoriatic skin during calcipotriol application are reported. Ten psoriatic patients (PASI score 3-14) were punch-biopsied on typical lesions before treatment and 2, 4 and 8 weeks after it. Two patients dropped out after 1 month because of lack of clinical response. Skin blocks were processed routinely for transmission electron microscopy and freeze-fracture techniqu ...
Pages: 186-189
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The effect of fumaric acid esters and dithranol on acanthosis and hyperproliferation in psoriasis vulgaris.
Bacharaçh-Buhles M, Röchling A, el Gammal S, Altmeyer P
n this study we investigated the histological changes, regression of acanthosis and rate of proliferation, that accompany the healing of psoriatic lesions after fumaric acid esters and dithranol treatment. Biopsies were taken before and during therapy as well as from neighbouring untreated, clinically uninvolved skin and healthy, non-psoriatic volunteers. Specimens were assessed using computer-sup ...
Pages: 190-193
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Patch test study with calcipotriol ointment in different patient groups, including psoriatic patients with and without adverse dermatitis.
Fullerton A, Avnstorp C, Agner T, Dahl JC, Olsen LO, Serup J
One hundred and sixty-eight individuals (psoriatic patients treated with calcipotriol with dermatitis due to calcipotriol, psoriatic patients treated with calcipotriol with no dermatitis, psoriatic patients never treated with calcipotriol, patients with eczema and healthy volunteers) were patch-tested (Finn chambers, back, 48 h) with dilutions of calcipotriol ointment (50, 10, 2, 0.4 micrograms/g) ...
Pages: 194-202
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Expression of the p53 protein in sun-damaged skin.
Barnadas MA1, Colomo L, Curell R, De Moragas JM.
The expression of the p53 protein in photodamaged skin from the face, forearm and neck of 18 subjects was compared to non-exposed skin taken at autopsy from the abdomens of 9 subjects of the same age. Paraffin sections and the polyclonal antibody CM1 were used with the ABC technique. The p53 protein was expressed in the nuclei of keratinocytes in 7 of the 18 samples obtained from sun-exposed skin ...
Pages: 203-204
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Neuropeptide- and capsaicin-induced histamine release in skin monitored with the microdialysis technique.
Huttunen M, Harvima IT, Ackermann L, Harvima RJ, Naukkarinen A, Horsmanheimo M
Mast cells are thought to be involved in neurogenic inflammation in skin, and numerous neuropeptides are known to degranulate mast cells. We monitored histamine release in skin in situ with the microdialysis method after skin challenge with neuropeptide injections (10 microM substance P, vasoactive intestinal peptide and calcitonin gene-related peptide), capsaicin injection (30 microM) and 0.1% ca ...
Pages: 205-209
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Interleukin-8 immunoreactivity in malignant tumours of the skin.
Bornscheuer E, Schröder JM, Christophers E, Sticherling M
In the past, interleukin-8 (IL-8) could be demonstrated within keratinocytes in normal epidermis and inflammatory skin diseases, like psoriasis and eczema. Using monoclonal antibodies, the distribution of IL-8 immunoreactivity was inversely related to the density of inflammatory infiltrate. Other in vitro observations indicated IL-8 to be a growth factor for keratinocytes. These results prompted a ...
Pages: 210-213
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Preferential expression of T-cell receptor V beta-chains in atopic eczema.
Neuber K, Löliger C, Köhler I, Ring J
Chronic skin colonization with Staphylococcus aureus is a characteristic feature of atopic eczema, and about 60% of S. aureus strains isolated from the skin of patients with atopic eczema secrete enterotoxins. T-cell stimulation by staphylococcal enterotoxins is restricted to the V beta-chain of the T-cell receptor. Therefore, the expression of different V beta-chains (V beta 3, 5 a,b,c, 6, 8, 12) ...
Pages: 214-218
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Levels of fluconazole in normal and diseased nails during and after treatment of onychomycoses in toe-nails with fluconazole 150 mg once weekly.
Faergemann J, Laufen H
Thirty-six patients with onychomycoses of their toe-nails were included in a double-blind, parallel-group comparative study of fluconazole 150 mg once weekly and griseofulvin 1,000 mg once daily for 12 months, or earlier if cured. Every month during treatment and in cured patients 3 and 6 months after stop of treatment one toe-nail was clipped and serum samples were taken. In patients treated with ...
Pages: 219-221
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Cell adhesion molecule expression in cutaneous lesions of dermatomyositis.
Hausmann G, Mascaró JM Jr, Herrero C, Cid MC, Palou J, Mascaró JM
Chronic inflammation seems to play a major role in skin and muscle cell damage in dermatomyositis. Adhesion molecules and their ligands are fundamental in regulating inflammation. We have carried out an immunohistochemical analysis of different activation-inducible adhesion markers in 15 biopsy specimens from dermatomyositis skin lesions. Consistent findings were the increased expression of interc ...
Pages: 222-225
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Diagnosis of Chlamydia trachomatis infection in high-risk females with PCR on first void urine.
Olafsson JH, Davídsson S, Karlsson SM, Pálsdóttir R, Steingrímsson O
Recently the polymerase chain reaction (PCR) has been shown to be more sensitive than older methods in detecting Chlamydia trachomatis, when performed on endocervical swabs. A total of 203 high-risk females were enrolled in a comparative study of 3 methods for diagnosing C. trachomatis infections: McCoy cell culture and Amplicor PCR on endocervical swabs, and urine. Thirty-four had positive cultur ...
Pages: 226-227
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Psoriasis treatment: bathing in a thermal lagoon combined with UVB, versus UVB treatment only.
Olafsson JH, Sigurgeirsson B, Pálsdóttir R
We have compared bathing in a thermal lagoon in Iceland, combined with UVB treatment, to UVB treatment only in an open comparative study. Twenty-three psoriasis patients bathed 3 times daily and were treated with UVB 5 times a week for 4 weeks. The control group was only treated with UVB 5 times a week for 4 weeks. Psoriasis Area and Severity Index (PSAI) was used to estimate the severity of the d ...
Pages: 228-230
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Cavity foot ulcers in diabetic patients: a comparative study of cadexomer iodine ointment and standard treatment. An economic analysis alongside a clinical trial.
Apelqvist J, Ragnarson Tennvall G
Diabetic foot ulcers with exposure of tendon, muscle, or bone imply a high probability for deep infections and amputations. Delayed healing times are often described. The aim of this study was to compare the clinical effect and economic cost of cadexomer iodine with standard treatment in diabetic feet with cavity ulcers. Patients with deep, exudative foot ulcers were included in a 12-week open, ra ...
Pages: 231-235
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Treatment of ischaemic digital ulcers and prevention of gangrene with intravenous iloprost in systemic sclerosis.
Zachariae H, Halkier-Sørensen L, Bjerring P, Heickendorff L
Twelve patients with systemic sclerosis were treated with intravenous infusions of the prostacyclin-stable analogue iloprost 0.5-2.0 ng/kg/min for 6 h from 8 to 13 days. Imminent gangrene was stopped in 2 patients and followed by healing. In 4 of 6 patients iloprost led to complete healing of ischaemic ulcers and in the remaining 2 patients to partial healing. One patient with severe Raynaud's phe ...
Pages: 236-238
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Acute multifocal skin necrosis: synergism between invasive streptococcal infection and cocaine-induced tissue ischaemia?
Hoeger PH, Haupt G, Hoelzle E
A 30-year-old pregnant woman with full thickness skin necrosis following parenteral abuse of cocaine and heroine is described. Three lesions occurred simultaneously on the trunk and right knee subsequent to an abscess on the left thigh from which S. pyogenes group A and S. aureus were isolated. Histology revealed necrotic subcutaneous tissue with obliterated vessels and a mixed inflammatory infilt ...
Pages: 239-241
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Infantile acrodermatitis of Gianotti-Crosti and Lyme borreliosis.
Baldari U, Cattonar P, Nobile C, Celli B, Righini MG, Trevisan G
No abstract available
Pages: 242-243
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Naevus lipomatosus cutaneous superficialis: overlap with connective tissue naevi.
Orteu CH, Hughes JR, Rustin MH
No abstract available
Pages: 243-245
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Multiple symmetrical lipomatosis in a patient on long-term corticosteroid therapy.
Khanna N, Dogra D, Rathi SK, Ravindraprasad JS.
No abstract available
Pages: 245-246
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Healing rate of skin ulcers.
Spencer RP
No abstract available
Pages: 246-247
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Scrotal angiokeratoma in a young man.
Hisa T, Taniguchi S, Goto Y, Teramae H, Osato K, Kakudo K, Takigawa M
No abstract available
Pages: 248-249
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Hepatitis C virus and sexual transmission.
Worm AM, Westh H, Kvinesdal BB, Wantzin PS
No abstract available
Pages: 249-250
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Penile metastases from bladder carcinoma.
Filosa G, Bugatti L, Peris K, Chimenti S
No abstract available
Pages: 250-251
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The sarcoidosis-lymphoma syndrome: acceleration of the cutaneous sarcoidosis during chemotherapy of the lymphoma.
Keohane SG, Savin JA, Tidman MJ, Anderson JA, Carey FA.
No abstract available
Pages: 251-253
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Paraneoplastic pemphigus: oral involvement as the sole manifestation.
Bialy-Golan A, Brenner S, Anhalt GJ
No abstract available
Pages: 253-254
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