Content

Content - Volume 80, Issue 2

Editor's choice in this issue

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The systemic nature of contact hypersensitivity
Peter Friedmann
This article does not have an abstract.
Page: 81
Abstract  PDF
Characterization and Comparison of Reconstructed Skin Models: Morphological and Immunohistochemical Evaluation: Investigative Reports
Esther Boelsma, Susan Gibbs, Claudine Faller, Maria Ponec
Reconstructed human skin equivalents are currently being investigated as in vitro models for the prediction of human skin toxicity and irritation responses. Three different industrial reconstructed skin models (EpiDerm, Episkin and SkinEthic) and one in-house equivalent were characterized and compared using light microscopy, immunohistochemistry and reduction of (3-[4,5-dimethylthiazole-2- ...
Pages: 82-88
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Covalently Bound Lipids in Reconstructed Human Epithelia
Maria Ponec, Esther Boelsma, Arij Weerheim
The composition of free and covalently bound lipids in reconstructed epithelia generated with normal human keratinocytes, HaCaT cells and squamous carcinoma cells was investigated and compared with native skin. Stratum corneum isolated from native human and reconstructed epidermis was subjected to extensive extraction with chloroform-methanol mixtures followed by alkaline hydrolysis to release co ...
Pages: 89-93
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Exposure of Human Keratinocytes and Fibroblasts In Vitro to Nickel Sulphate Ions Induces Synthesis of Stress Proteins Hsp72 and Hsp90
S. Carroll, E. J. Wood
Exposure of the epidermis to nickel-containing compounds is one of the most common causes of contact allergy and may indicate that exposure of skin cells to nickel ions causes stress. In this study, cytotoxicity assays upon human keratinocytes and fibroblasts in monolayer culture indicated a 50% decrease in viability of both cell types at nickel sulphate concentrations in excess of 10-3
Pages: 94-97
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CD 2394, a Novel Synthetic Retinoid, Initiates an Embryonic Type of Differentiation in Hyperproliferative Skin
M. M. van Rossum, J. M. Mommers, P. E. J. van Erp, E. Leyninger, A. Clucas, P. C. M. van de Kerkhof
In human skin, there are 2 types of epidermal differentiation: normal differentiation, characterized by keratin 10 expression, and alternative differentiation. Alternative differentiation may be regeneration-associated differentiation (keratin 6 and 16) or re-induction of embryonic differentiation (expression of keratin 13, 15 and 19). The purpose of this study was to investigate the effect of th ...
Pages: 98-101
Abstract  PDF
Levels of Proelafin Peptides in the Sera of the Patients with Generalized Pustular Psoriasis and Pustulosis Palmoplantaris
Nobuhiko Tanaka, Akira Fujioka, Shingo Tajima, Akira Ishibashi, Shigehisa Hirose
The levels of proelafin peptides in the sera of patients with pustulosis palmoplantaris, a unique type of localized pustular psoriasis, and generalized pustular psoriasis were determined by competitive enzyme-linked immunosorbent assays using antibodies against synthetic proelafin polypeptides corresponding to the elastase inhibitor (elafin) and transglutaminase substrate domains. The sera of pat ...
Pages: 102-105
Abstract  PDF
Characterization by Phenotype of Families with Atopic Dermatitis: Clinical Reports
M. Bradley, I. Kockum, C. Söderhäll, M. van Hage-Hamsten, H. Luthman, M. Nordenskjöld, C.-F. Wahlgren
The aetiology of atopic dermatitis is unknown, but is probably multifactorial, with interactions between several genetic and environmental factors. Twin studies indicate a strong genetic factor, but the susceptibility genes are unknown. This paper, describing the phenotypes of family material, forms part of a large genetic study seeking to identify susceptibility genes for atopic dermatitis by li ...
Pages: 106-110
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Clinical Response to Gold as a Circulating Contact Allergen
Halvor Möller
In order to study the flare-up of contact allergy, 35 patients with a contact allergy to gold were given an intramuscular injection of 10 mg gold sodium thiomalate, i.e. the anti-rheumatic drug Myocrisin®. Clinical reactions comprised an eczematous flare-up of previously positive patch tests to gold and of a previous dermatitis, which occurred in 80% and 26%, respectively; a toxicoder ...
Pages: 111-113
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Treatment of Mosquito Bites with Ebastine: A Field Trial
A. Karppinen, L. Petman, A. Jekunen, H. Kautiainen, A. Vaalasti, T. Reunala
Wealing and pruritic, long­lasting papules are a common nuisance from mosquito bites. Antihistamines can be expected to decrease wealing, but their effect on the delayed bite symptoms needs to be elucidated. We studied the effect of ebastine in 28 mosquito-bite sensitive adult subjects exposed to Aedes communis bites in the field. Ebastine 20 mg and placebo were given for 4 days in a crossover f ...
Pages: 114-116
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Morphological Features of Spitz Naevus as Observed by Digital Videomicroscopy
Giovanni Pellacani, Anna Maria Cesinaro, Stefania Seidenari
Pages: 117-121
Abstract  PDF
Comparison of Dermatoscopic ABCD Rule and Risk Stratification in the Diagnosis of Malignant Melanoma
Henrik Lorentzen, Kaare Weismann, Robert O. Kenet, Lena Secher, Frederik Grønhøj Larsen
For didactic and documentation purposes the dermatoscopic ABCD rule and the dermatoscopic risk stratification have been proposed. The aim of this investigation was to compare the ability of the 2 methods to separate patients with cutaneous malignant melanoma from individuals with other pigmented skin lesions. Three dermatologists, experienced users of dermatoscopy, assessed macroscopic clinical a ...
Pages: 122-126
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Rosacea Fulminans in a Patient with Crohn's Disease: A Case Report and Review of the Literature
R. Romiti, T. Jansen, W. Heldwein, G. Plewig
Rosacea fulminans is a rare disorder of unknown cause that mainly affects postadolescent women, with abrupt onset and disfiguring course if left untreated. The simultaneous occurrence of rosacea fulminans and inflammatory bowel disease is rare and has been reported predominantly in the setting of ulcerative colitis. We describe here a case of rosacea fulminans in a patient with Crohn's disease an ...
Pages: 127-129
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Oesophageal Manometry and Video-radiology in Patients with Systemic Sclerosis: A Retrospective Study of its Clinical Value
Pia Ipsen, Henrik Egekvist, Karin Aksglaede, Hugh Zachariae, Peter Bjerring, Per Thommesen
The aim of this retrospective study was to evaluate the initial video-radiology and manometry in 40 consecutive patients with systemic sclerosis (n=21) or suspected systemic sclerosis (n=19) in relation to oesophageal symptoms; and, furthermore, to evaluate the consequence of radiographic or manometric findings in the oesophagus on diagnosis and treatment. Evaluating oesophageal abn ...
Pages: 130-133
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Treatment of Facial Verrucae with Topical Imiquimod Cream in a Patient with Human Immunodeficiency Virus
Kenneth Cutler, Mark H. Kagen, Philip C. Don, Patricia McAleer, Jeffrey M. Weinberg
Imiquimod is a recently developed imidazoquinolin heterocyclic amine that is an immune response modifier. Treatment with topical 5% imiquimod cream has shown promising results in the treatment of genital warts in immunocompetent individuals. We report here the first case of successful treatment with topical 5% imiquimod cream of facial verrucae in an individual with human immunodeficiency virus. ...
Pages: 134-135
Abstract  PDF
Sexually Transmitted Diseases and Sexual Behaviour in Men Attending an Outpatients' Clinic for Gay Men in Gothenburg, Sweden
Mats A. D. Christiansen, Gun-Britt Löwhagen
The prevalence of sexually transmitted diseases (STDs) diagnosed in men attending an outpatients' clinic for gay men from 1983 to 1997 and the results from a questionnaire survey concerning sexual behaviour conducted in 1994-96 are reported. The prevalence of gonorrhoea and chlamydia has decreased during the period, although in 1997 there was a micro-epidemic of gonorrhoea in gay men in Gothenbur ...
Pages: 136-139
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Incidence and Prognostic Significance of Skin Disease in Patients with HIV/AIDS: A 5-year Observational Study
Birgitte Løkke Jensen, Kaare Weismann, Jens Hein Sindrup, Jørgen Søndergaard, Karsten Schmidt
Mucocutaneous diseases are common in HIV-infected patients. The aim of the present study was to determine the observed frequency of skin diseases and their prognostic significance for the progression of HIV infection. In a cohort of 150 HIV-infected patients diagnosed from 1986 to 1987 the number of mucocutaneous diseases, the CD4+ cell count, time to development of AIDS and survival time were re ...
Pages: 140-143
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Granuloma Faciale Mimicking Rhinophyma: Response to Clofazimine
E. Gómez-de la Fuente, R. del Rio, M. Rodriguez, A. Guerra, J.L. Rodriguez-Peralto, L. Iglesias
This article does not have an abstract.
Page: 144
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Grover's Disease Associated with Waldenstr m's Macroglobulinemia and Neutrophilic Dermatosis
M. Roger, C. Valence, J. M. Bressieux, P. Bernard, A. Fur
This article does not have an abstract.
Pages: 145-146
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Book Review
The Editor-in-Chief
This article does not have an abstract.
Page: 146
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Absence of Azathioprine Hypersensitivity After Administration of its Active Metabolite 6-Mercaptopurine
Klaus Schmitt, Uli Pfeiffer, Helmut E. Stiehrle, Petra A. Thuermann
This article does not have an abstract.
Pages: 147-148
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Aquagenic Urticaria: A Case Report
Michihiro Hide, Yumi Yamamura, Seiko Sanada, Shoso Yamamoto
This article does not have an abstract.
Pages: 148-149
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Cutaneous Lesions of Multicentric Reticulohistiocytosis Developing in Herpes Zoster Lesions
Kaushal K. Verma, Rashmi Mittal
This article does not have an abstract.
Page: 150
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Solitary Milialike Idiopathic Calcinosis Cutis Unassociated with Down's Syndrome: Two Case Reports
Dai-Ho Kim, Hoon Kang, Sang-Hyun Cho, Young-Min Park
This article does not have an abstract.
Pages: 151-152
Abstract  PDF
Mohs Micrographic Surgery in Gothenburg, Sweden
Bo Stenquist, Ann-Marie Wennberg, Olle Larkö
This article does not have an abstract.
Page: 152
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Candida Folliculitis Mimicking Tinea Barbae
Mizuho Kurita, Saburo Kishimoto, Yukiko Kibe, Hideya Takenaka, Hirokazu Yasuno
This article does not have an abstract.
Pages: 153-154
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White Superficial Onychomycosis of a Toenail due to Microsporum canis
Hyun-Jeong Lee, Seog-Jun Ha, Sang-Jung Lee, Jin-Wou Kim, Baik-Kee Cho
This article does not have an abstract.
Page: 155
Abstract  PDF
Helicobacter pylori in Rosacea and Chronic Urticaria
Jose María Rojo-García, Miguel Angel Muñoz-Pérez, Jerónimo Escudero, Francisco Camacho, Pedro Hergueta, Juan Manuel Herrerías
This article does not have an abstract.
Pages: 156-157
Abstract  PDF
Herpes Simplex Virus-type 2 Seropositivity in a Danish Adult Population Denying Previous Episodes of Genital Herpes
Carsten Sand Petersen, Frederik Grønhøj Larsen, Claus Zachariae, Michael Heidenheim
This article does not have an abstract.
Page: 158
Abstract  PDF
Cutaneous Horn on Condyloma Acuminatum
Arun Agarwalla, Chandra Shekhar Agrawal, Amarnath Thakur, Vijay Kumar Garg, Arun Joshi, Sudha Agrawal, Mary Jacob
This article does not have an abstract.
Page: 159
Abstract  PDF