Content

Content - Volume 81, Issue 6

Editor's choice in this issue

All articles

Does Antisense Make Sense in Dermatology?
Piet E. J. Van Erp, Miriam Wingens
The concept of antisense technology is elegant but misleadingly simple. Short oligodeoxynucleotides (ODNs) complementary to a target messenger RNA form DNA-RNA hybrids by WatsonCrick base pairing rules, and interfere with expression of the encoded protein. The potential sequence specificity of antisense ODNs makes them attractive as molecular drugs in the treatment of human diseases. The skin is r ...
Pages: 385-391
Abstract  PDF
LETTER TO THE EDITOR
Efficacy of a New Class of Perfluoropolyethers in the Prevention of Irritant Contact Dermatitis
Perfluoropolyethers (Fomblin® HC products) are chemical nonreactive polymers with special physico-chemical properties that recently showed promise as protective preparations in the prevention of irritant contact dermatitis. We evaluated the efficacy of a new class ofperfluoropolyethers (perfluoropolyether phosphate, Fomblin® HC/P2) in the prevention of experimentally induced cumulative ir ...
Pages: 392-394
Abstract  PDF
LETTER TO THE EDITOR
Response to Thermal Stimuli in Skin Pretreated with Sodium Lauryl Sulfate
Skin irritation is mostly a multifactorial process. Competitive effects of different chemical irritants are well known. This study investigates the influence of a thermal stimulus on skin pre-irritated with sodium lauryl sulfate (SLS). Seventy-seven volunteers were patch-tested with SLS 0.25% and 0.5% for 48h. Water served as control. Skin reaction was evaluated by measurement of transepidermal wa ...
Pages: 395-397
Abstract  PDF
LETTER TO THE EDITOR
Structural Analogues Inhibit the Sensitizing Capacity of Carvone
The aim of the study was to investigate the effect of non-allergenic structural analogues on the sensitizing potential of carvone, a fragrance allergen. The possibility that one molecule might inhibit the allergenic activity of another molecule has been debated for 25 years. The Research Institute for Fragrance Materials states that the sensitizing activity from certain fragrance aldehydes is "que ...
Pages: 398-402
Abstract  PDF
LETTER TO THE EDITOR
Tandem Application of Sodium Lauryl Sulfate and n-Propanol Does Not Lead to Enhancement of Cumulative Skin Irritation
Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunt ...
Pages: 403-405
Abstract  PDF
LETTER TO THE EDITOR
Differential Proteinase Expression by Pseudomonas aeruginosa Derived from Chronic Leg Ulcers
Pseudomonas aeruginosa colonizes 20-30 % of all venous leg ulcers. Hypothetically, P. aeruginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elasta ...
Pages: 406-409
Abstract  PDF
LETTER TO THE EDITOR
Increased Psychiatric Morbidity in Female Outpatients with Skin Lesions on Visible Parts of the Body
Psychiatric disorders are frequent among patients with skin diseases. We aimed at identifying factors associated with psychiatric morbidity in dermatological outpatients. All adults attending the outpatient clinics of a dermatological hospital on predetermined days were given the 12-item General Health Questionnaire. The dermatologists indicated the diagnosis and location of skin lesions and rated ...
Pages: 410-414
Abstract  PDF
LETTER TO THE EDITOR
Occupational Non-melanoma Skin Cancer
Non-melanoma skin cancer is historically known to be associated with certain professions. Reporting is mandatory in Denmark when occupational exposure is suspected. In a retrospective register-based study of all cases of suspected occupational non-melanoma skin cancer reported to the Directorate of National Labour Inspection and the National Board of Industrial Injuries in Denmark in the period Ja ...
Pages: 415-417
Abstract  PDF
LETTER TO THE EDITOR
Serum IgE Reactivity to Malassezia furfur Extract and Recombinant M. furfur Allergens in Patients with Atopic Dermatitis
IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1, rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the ...
Pages: 418-422
Abstract  PDF
LETTER TO THE EDITOR
Effects of Short-term Oral Acitretin Therapy on Peripheral Nerve Function: A Prospective Neurological and Neurophysiological Study
The aim of the present prospective study was to substantiate possible side effects of short-term oral acitretin therapy (1mg/ kg/day) on peripheral nerve function of 13 patients with severe keratinization disorders. Clinical neurological examination before and 1 and 3 months after onset of treatment was unremarkable in all patients; however, a significant alteration of one or more neurophysiologic ...
Pages: 423-425
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REVIEW
Gemcitabine-induced Acute Lipodermatosclerosis-like Reaction
Gemcitabine is considered to be a well-tolerated and safe cytostatic drug because of the relative lack of side effects. Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. We report one patient with squamous cell carcinoma of the lung who developed a gemcitabine-induced cutaneous reaction mimicking acute lipodermatosclerosis. This case ...
Pages: 426-428
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Ultraviolet A Sunbed Used for the Treatment of Scleroderma
This article does not have an abstract.
Pages: 432-433
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Sensitivity to Rubber Chemicals and Latex Among Hemodialysis Patients
This article does not have an abstract.
Pages: 434-435
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Constitutional Pompholyx Eczema Complicated by Secondary Lymphoedema
This article does not have an abstract.
Pages: 437-438
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Narrow-band UVB Treatment in Atopic Dermatitis
This article does not have an abstract.
Pages: 439-440
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LETTER TO THE EDITOR
Kerion due to Trichophyton mentagrophytes: Responsiveness to Fluconazole versus Terbinafine in a Child
This article does not have an abstract.
Pages: 444-445
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LETTER TO THE EDITOR
Extensive Calcinosis Cutis in Association with Systemic Lupus Erythematosus
This article does not have an abstract.
Pages: 446-447
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LETTER TO THE EDITOR
A Long-lasting Verrucous Plaque on the Hand Revealed as Tuberculosis Cutis
This article does not have an abstract.
Pages: 448-449
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LETTER TO THE EDITOR
Generalized Bullous Fixed Drug Eruption after Influenza Vaccination, Simulating Bullous Pemphigoid
This article does not have an abstract.
Pages: 450-451
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BOOK REVIEWS
This article does not have an abstract.
Page: 453
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