Content

Content - Volume 81, Issue 6

All articles

REVIEW
Does Antisense Make Sense in Dermatology?
Piet E. J. Van Erp, Miriam Wingens
The concept of antisense technology is elegant but misleadingly simple. Short oligodeoxynucleotides (ODNs) complementary to a target messenger RNA form DNA-RNA hybrids by WatsonCrick base pairing rules, and interfere with expression of the encoded protein. The potential sequence specificity of antisense ODNs makes them attractive as molecular drugs in the treatment of human diseases. The skin is r ...
Pages: 385-391
Abstract  PDF
INVESTIGATIVE REPORT
Efficacy of a New Class of Perfluoropolyethers in the Prevention of Irritant Contact Dermatitis
Sibylle Schliemann-Willers, Walter Wigger-Alberti, Peter Elsner
Perfluoropolyethers (Fomblin® HC products) are chemical nonreactive polymers with special physico-chemical properties that recently showed promise as protective preparations in the prevention of irritant contact dermatitis. We evaluated the efficacy of a new class ofperfluoropolyethers (perfluoropolyether phosphate, Fomblin® HC/P2) in the prevention of experimentally induced cumulative ir ...
Pages: 392-394
Abstract  PDF
INVESTIGATIVE REPORT
Response to Thermal Stimuli in Skin Pretreated with Sodium Lauryl Sulfate
Harald Löffler, Jun Aramaki, Isaak Effendy
Skin irritation is mostly a multifactorial process. Competitive effects of different chemical irritants are well known. This study investigates the influence of a thermal stimulus on skin pre-irritated with sodium lauryl sulfate (SLS). Seventy-seven volunteers were patch-tested with SLS 0.25% and 0.5% for 48h. Water served as control. Skin reaction was evaluated by measurement of transepidermal wa ...
Pages: 395-397
Abstract  PDF
INVESTIGATIVE REPORT
Structural Analogues Inhibit the Sensitizing Capacity of Carvone
Ann-Therese Karlberg, Anna-Malin Nilsson, Kristina Luthman, J. Lars G. Nilsson
The aim of the study was to investigate the effect of non-allergenic structural analogues on the sensitizing potential of carvone, a fragrance allergen. The possibility that one molecule might inhibit the allergenic activity of another molecule has been debated for 25 years. The Research Institute for Fragrance Materials states that the sensitizing activity from certain fragrance aldehydes is "que ...
Pages: 398-402
Abstract  PDF
INVESTIGATIVE REPORT
Tandem Application of Sodium Lauryl Sulfate and n-Propanol Does Not Lead to Enhancement of Cumulative Skin Irritation
Ulrike P. Kappes, Nina Göritz, Walter Wigger-Alberti, Christian Heinemann, Peter Elsner
Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunt ...
Pages: 403-405
Abstract  PDF
INVESTIGATIVE REPORT
Differential Proteinase Expression by Pseudomonas aeruginosa Derived from Chronic Leg Ulcers
Artur Schmidtchen, Helene Wolff, Carita Hansson
Pseudomonas aeruginosa colonizes 20-30 % of all venous leg ulcers. Hypothetically, P. aeruginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elasta ...
Pages: 406-409
Abstract  PDF
CLINICAL REPORT
Increased Psychiatric Morbidity in Female Outpatients with Skin Lesions on Visible Parts of the Body
Angelo Picardi, Damiano Abeni, Cristina Renzi, Mario Braga, Pietro Puddu, Paolo Pasquini
Psychiatric disorders are frequent among patients with skin diseases. We aimed at identifying factors associated with psychiatric morbidity in dermatological outpatients. All adults attending the outpatient clinics of a dermatological hospital on predetermined days were given the 12-item General Health Questionnaire. The dermatologists indicated the diagnosis and location of skin lesions and rated ...
Pages: 410-414
Abstract  PDF
CLINICAL REPORT
Occupational Non-melanoma Skin Cancer
Ulrikke Lei, Tania Nicole Masmas, Gerda Frentz
Non-melanoma skin cancer is historically known to be associated with certain professions. Reporting is mandatory in Denmark when occupational exposure is suspected. In a retrospective register-based study of all cases of suspected occupational non-melanoma skin cancer reported to the Directorate of National Labour Inspection and the National Board of Industrial Injuries in Denmark in the period Ja ...
Pages: 415-417
Abstract  PDF
CLINICAL REPORT
Serum IgE Reactivity to Malassezia furfur Extract and Recombinant M. furfur Allergens in Patients with Atopic Dermatitis
Arezou Zargari, Hojjat Eshaghi, Ove Bäck, Sgo Johansson, Annika Scheynius
IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1, rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the ...
Pages: 418-422
Abstract  PDF
CLINICAL REPORT
Effects of Short-term Oral Acitretin Therapy on Peripheral Nerve Function: A Prospective Neurological and Neurophysiological Study
E. Chroni, S. Georgiou, A. Monastirli, C. Paschalis, D. Tsambaos
The aim of the present prospective study was to substantiate possible side effects of short-term oral acitretin therapy (1mg/ kg/day) on peripheral nerve function of 13 patients with severe keratinization disorders. Clinical neurological examination before and 1 and 3 months after onset of treatment was unremarkable in all patients; however, a significant alteration of one or more neurophysiologic ...
Pages: 423-425
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CLINICAL REPORT
Gemcitabine-induced Acute Lipodermatosclerosis-like Reaction
Chia-Yu Chu, Chih-Hsin Yang, Hsien-Ching Chiu
Gemcitabine is considered to be a well-tolerated and safe cytostatic drug because of the relative lack of side effects. Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. We report one patient with squamous cell carcinoma of the lung who developed a gemcitabine-induced cutaneous reaction mimicking acute lipodermatosclerosis. This case ...
Pages: 426-428
Abstract  PDF
LETTER TO THE EDITOR
Addition of Pentoxifylline Could Reduce the Side Effects of Fumaric Acid Esters in the Treatment of Psoriasis
Markus Friedrich, Wolfram Sterry, Anja Klein Renérückert, Wolf Dietrich Döcke, Khusru Asadullah
This article does not have an abstract.
Pages: 429-430
Abstract  PDF
LETTER TO THE EDITOR
Videodermatoscopic Approach to Porokeratosis of Mibelli: A Useful Tool for the Diagnosis
Domenico D'Amico, Mario Vaccaro, Claudio Guarneri, Francesco Borgia, Serafinella P. Cannavó, Fabrizio Guarneri
This article does not have an abstract.
Pages: 431-432
Abstract  PDF
LETTER TO THE EDITOR
Ultraviolet A Sunbed Used for the Treatment of Scleroderma
Aarne Oikarinen, Anina Knuutinen
This article does not have an abstract.
Pages: 432-433
Abstract  PDF
LETTER TO THE EDITOR
Sensitivity to Rubber Chemicals and Latex Among Hemodialysis Patients
Eustachio Nettis, Porzia Dambra, Maria Teresa Paradiso, Vincenzo Montinaro, Saverio Carabellese, Leonilde Cenci, Antonio Ferrannini, Alfredo Tursi
This article does not have an abstract.
Pages: 434-435
Abstract  PDF
LETTER TO THE EDITOR
Granulocyte Colony-Stimulating Factor (G-CSF) Induced Disseminated Erythema with CD68 Positive Histiocytes
Yuki Tomita, Tadamichi Shimizu, Hiroshi Shimizu
This article does not have an abstract.
Pages: 436-437
Abstract  PDF
LETTER TO THE EDITOR
Constitutional Pompholyx Eczema Complicated by Secondary Lymphoedema
Joanna E. Gach, Clodagh M. King
This article does not have an abstract.
Pages: 437-438
Abstract  HTML  PDF
LETTER TO THE EDITOR
Narrow-band UVB Treatment in Atopic Dermatitis
Mika Hjerppe, Taina Hasan, Irma Saksala, Timo Reunala
This article does not have an abstract.
Pages: 439-440
Abstract  PDF
LETTER TO THE EDITOR
Acrokeratosis Paraneoplastica (Bazex's Syndrome): Unusual Association with a Peripheral T-cell Lymphoma
Yu-Chih Lin, Chia-Yu Chu, Hsien-Ching Chiu
This article does not have an abstract.
Pages: 440-441
Abstract  PDF
LETTER TO THE EDITOR
Photosensitivity from Colophony in a Case of Chronic Actinic Dermatitis Associated with Contact Allergy from Colophony
Yoshinori Kuno, Mami Kato
This article does not have an abstract.
Pages: 442-443
Abstract  PDF
LETTER TO THE EDITOR
Kerion due to Trichophyton mentagrophytes: Responsiveness to Fluconazole versus Terbinafine in a Child
Nina Otberg, Hans Jürgen Tietz, Beate Maria Henz, Norbert Haas
This article does not have an abstract.
Pages: 444-445
Abstract  PDF
LETTER TO THE EDITOR
Extensive Calcinosis Cutis in Association with Systemic Lupus Erythematosus
Sonal Bhatia, Nanette B. Silverberg, Philip C. Don, Jeffrey M. Weinberg
This article does not have an abstract.
Pages: 446-447
Abstract  PDF
LETTER TO THE EDITOR
A Long-lasting Verrucous Plaque on the Hand Revealed as Tuberculosis Cutis
Giulio Tosti, Vincenzo Bettoli, Annarosa Virgili, Maria Rita Rossi, Ermete Altieri
This article does not have an abstract.
Pages: 448-449
Abstract  PDF
LETTER TO THE EDITOR
Generalized Bullous Fixed Drug Eruption after Influenza Vaccination, Simulating Bullous Pemphigoid
I. García-Doval, E. Rosón, C. Feal, C. De La Torre, T. Rodríguez, M. J. Cruces
This article does not have an abstract.
Pages: 450-451
Abstract  PDF
BOOK REVIEW
BOOK REVIEWS
This article does not have an abstract.
Page: 453
Abstract  PDF