Content

Content - Volume 86, Issue 4

Editor's choice in this issue

All articles

INVESTIGATIVE REPORT
Comparison of Growth-inhibitory Agents by Fluorescence Imaging of Human Skin Re-epithelialization In vitro
Sofi Forsberg, Ulpu Saarialho-Kere and Ola Rollman
Drug screening procedures should preferably utilize experimental settings mimicking the in vivo situation. The aim of this study was to evaluate a skin explant model as a tool to identify topical agents with anti-proliferative properties in human epidermis. Re-epithelialization was initiated from a skin punch biopsy explanted onto de-epidermized dermis and cultured at the air–liquid interface in ...
Pages: 292-299
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INVESTIGATIVE REPORT
Upregulation of the Wnt/β-catenin Pathway Induced by Transforming Growth Factor-β in Hypertrophic Scars and Keloids
Madoka Sato
Hypertrophic scars and keloids represent a dysregulated response to cutaneous wounds, which results in an exces­sive deposition of collagen. Transforming growth factor-β (TGF-β) is the key regulator in the pathogenesis of fibrosis. Accumulating evidence suggests that Wnt signalling and its effector β-catenin also play an important role in wound healing. The role of Wnt/β-catenin signalling in ...
Pages: 300-307
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INVESTIGATIVE REPORT
Mechanical Properties and Barrier Function of Healthy Human Skin
Louise Pedersen and Gregor B.E. Jemec
The aim of this study was to investigate the relation­ship between the mechanical properties and the epidermal barrier function of the skin in vivo. A suction cup device commonly used for measurement of skin mechanics was used to provide a defined stress to the skin using the ventral forearm in 16 healthy volunteers. The integrity of the barrier function was assessed by trans-epidermal water loss ...
Pages: 308-311
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INVESTIGATIVE REPORT
In Vitro Activity of R126638 and Ketoconazole Against Malassezia Species
Jan Faergemann, Jannie Ausma and Marcel Borgers
The in vitro activity of a new triazole R126638 against Malassezia yeasts was compared with that of ketoconazole. With the agar dilution technique, minimal inhibitory concentrations were lower for R126638 compared with ketoconazole against Malassezia globosa, M. obtusa, M. slooffiae, M. restricta and two strains of M. sympodialis. On human stratum corneum in vitro, both R126638 and ketoconazole we ...
Pages: 312-315
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INVESTIGATIVE REPORT
In vivo Porphyrin Production by P. acnes in Untreated Acne Patients and its Modulation by Acne Treatment
Claudia Borelli, Kathrin Merk, Martin Schaller, Karl Jacob, Michael Vogeser, Günther Weindl, Ursula Berger and Gerd Plewig
Propionibacterium acnes is often discussed as a contributing pathogenic factor in the aetiology of acne lesions. The aim of this study was to test which porphyrin patterns are synthesized by P. acnes in vivo in untreated acne patients and during standard acne regimens. These photosensitive compounds are potential targets for photo­dynamic therapy of acne and need to be better characterized in the ...
Pages: 316-319
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CLINICAL REPORT
Demographic and Behavioural Factors in Tanzanian and Norwegian Patients with Sexually Transmitted Infections
Arvid Nilsen, Davis Mwakagile, Guerino Chalamila, Nina Langeland, Roald Matre and Lars Haarr
To evaluate whether differences in demographic or behavioural factors might explain differences in reported or diagnosed sexually transmitted infections (STI), we have compared data from 1097 Tanzanian and Norwegian STI patients. Most demographic data were similar, whereas some behavioural data differed. Norwegian patients reported significantly higher numbers of sexual partners than Tanzanian. Th ...
Pages: 320-328
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CLINICAL REPORT
Levocetirizine for Treatment of Immediate and Delayed Mosquito Bite Reactions
Ari Karppinen, Henrikki Brummer-Korvenkontio, Leena Petman, Hannu Kautiainen, Jean-Pierre Hervé and Timo Reunala
People frequently experience whealing and delayed papules from mosquito bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to mosquito bites. On the third treatment day the subjects received two Aedes aegypti bites ...
Pages: 329-331
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CLINICAL REPORT
Frequency and Prognostic Value of IgA and IgG Endomysial Antibodies in Recurrent Aphthous Stomatitis
Malgorzata Olszewska, Jadwiga Sulej and Bronisław Kotowski
Recurrent aphthous stomatitis is a common disease of the oral mucous membranes. Currently a hypothesis is being discussed that it might be pathogenetically related to coeliac disease. We evaluated the frequency of coeliac disease anti-endomysial (or anti-transglutaminase) antibodies in patients with recurrent aphthous stomatitis. Blood samples from 42 patients were evaluated and 2/42 (4.7%) were I ...
Pages: 332-334
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CLINICAL REPORT
Neurosyphilis is Unlikely in Patients with Late Latent Syphilis and a Negative Blood VDRL-Test
Stefan Wöhrl and Alexandra Geusau
Patients with latent syphilis or syphilis of unknown dura­­tion should be evaluated for tertiary disease and neuro­syphilis. The aim of this retrospective study was to determine relevant serological parameters for the identi­fication of those individuals with syphilis who are most likely to have neurosyphilis and who therefore require lumbar puncture. After excluding repeated estimates and pat ...
Pages: 335-339
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CLINICAL REPORT
Cardiovascular Reactivity to Experimental Stress in Psoriasis: a Controlled Investigation
Mario Mastrolonardo, Angelo Picardi, Dario Alicino, Antonello Bellomo and Paolo Pasquini
A defective response of psoriatic skin to β-adrenergic stimulation has been implicated in the pathophysiology of psoriasis. A psychophysiological study was planned to investigate whether the β-adrenergic receptor hyporesponsiveness found in psoriatic skin can also be detected in other systems. Twenty-five psoriatic patients and 50 healthy controls were submitted to a standardized stressful proce ...
Pages: 340-344
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CLINICAL REPORT
Positive Patch Test Reactions to Nickel Sulphate are not Modified by Neighbouring Negative Fragrance Patch Tests A Multicenter-study by the German Contact Dermatitis Research Group
Jochen Brasch, Michael Weichenthal, Christiane Szliska, Harald Löffle, Patrick Koch4, Jürgen Grabbe, Vera Mahler, Bo Kreilgård and Ulla Hoeck
It is tacitly assumed that a positive patch test reaction is not affected by adjacent negative tests. However, despite its fundamental importance for the interpretation of test reactions this assumption has not been proven. To test this assumption, special TRUE-test® strips were prepared containing placebo, nickel sulphate and fragrance mix as the only allergens, separated by distances of 1 cm an ...
Pages: 345-347
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CLINICAL REPORT
Progressive Nodular Histiocytoma Associated with Thrombocytopenia with Absent Radii (TAR Syndrome) and Angiofibromas
Elena Rosón, Ángeles Flórez, Carlos Feal, Carlos De La Torre, Ignacio García-Doval, Teresa Abalde and Manuel Cruces
A 50-year-old woman was admitted due to a long-­standing history of cutaneous lesions, which were gradually increasing in number and size, located on the trunk and extremities. Histological studies confirmed the initial clinical diagnosis of histiocytomas. Moreover, the patient had numerous smooth erythematous papules on her chin and around her nose, which were diagnosed histologically as angiofi ...
Pages: 348-350
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CLINICAL REPORT
Childhood Oral Mucous Membrane Pemphigoid Presenting as Desquamative Gingivitis in a 4-year-old Girl
Silvia V. Lourenço, Paula Boggio, Luis E. Agner Machado Martins, Cláudia G. Santi, Valeria Aoki and Marcello Menta Simonsen Nico
Mucous membrane pemphigoid is a chronic inflammatory, bullous subepithelial auto-immune disease, with predominant involvement of the mucosal surfaces. Oral mucous membrane pemphigoid occurring in childhood is extremely rare. We describe a new case of this entity occurring in a 4-year-old girl who presented with desquamative gingivitis. Diagnosis was based on clinical presentation, histopathology, ...
Pages: 351-354
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LETTER TO THE EDITOR
Pemphigus Vulgaris of the Uterine Cervix: Misinterpretation of Papanicolaou Smears
Alice Z. C. Lobo, Joaquim X. de Sousa Jr., Valéria Aoki, Mirian N. Sotto, Elsa Aida Gay de Pereyra, Celina W. Maruta and Cláudia G. Santi
This article does not have an abstract.
Pages: 355-356
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LETTER TO THE EDITOR
IgA/IgG Pemphigus: A New Atypical Subset of Pemphigus?
Cezary Kowalewski, Takashi Hashimoto, Masayuki Amagai, Stefania Jablonska, Wojciech Mackiewicz and Katarzyna Wozniak
This article does not have an abstract.
Pages: 357-358
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LETTER TO THE EDITOR
Erythema Multiforme Following Live Attenuated Trivalent Measles-Mumps-Rubella Vaccine
Maria Luisa Bernardini, Gianfranco D’Angelo, Nicola Oggiano, Anna Campanati, Anna Ficcadenti, Giovanni Valentino Coppa and Annamaria Offidani
This article does not have an abstract.
Pages: 359-360
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LETTER TO THE EDITOR
Hand–Foot Syndrome Caused by Brown Spider Bite
Raymond Farah, Moshe Shay and Ora Bitterman
This article does not have an abstract.
Pages: 361-362
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LETTER TO THE EDITOR
Facial Superficial Granulomatous Pyoderma Treated with Cyclosporin: Not Always a Benign Condition
Seau Tak Cheung, Ulises Zanetto and Camilo Diaz
This article does not have an abstract.
Pages: 362-363
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LETTER TO THE EDITOR
Renal Failure Associated with Blue Toe Syndrome: Effective Treatment with Intravenous Prostaglandin E-1
Kazuya Minatohara
This article does not have an abstract.
Pages: 364-365
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LETTER TO THE EDITOR
Multiple Keratoacanthomas as an Untoward Response to Imiquimod Therapy for Actinic Keratoses
Stephen D’Addario and Patrick R. Carrington
This article does not have an abstract.
Pages: 366-367
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LETTER TO THE EDITOR
Onychomatricoma with Pterygium Aspect: Unusual Clinical Presentation
Sophie Goettmann, Inès Zaraa and Isabelle Moulonguet
This article does not have an abstract.
Pages: 369-370
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LETTER TO THE EDITOR
Fixed Drug Eruption due to Propranolol
Elisa Zaccaria, Francesco Gualco, Francesco Drago and Alfredo Rebora
This article does not have an abstract.
Pages: 371-371
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LETTER TO THE EDITOR
Treatment of Atopic Dermatitis with 1% Hydrocortisone and 25% Pentane-1,5-diol: Effect on Staphylococcus aureus
Mari Helen Sandström Falk, Tore Särnhult, Thomas Hedner and Jan Faergemann
This article does not have an abstract.
Pages: 372-373
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LETTER TO THE EDITOR
Steatocystoma Multiplex Presenting as Acral Subcutaneous Nodules
Teruki Yanagi and Tetsuri Matsumura
This article does not have an abstract.
Pages: 374-375
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LETTER TO THE EDITOR
Treatment of Psoriasis Vulgaris with Narrow-band UVB and Topical Maxacalcitol
Tomonori Takekoshi, Akihiko Asahina, Mayumi Komine and Kunihiko Tamaki
This article does not have an abstract.
Pages: 375-376
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LETTER TO THE EDITOR
Non-attendance in Adult Dermatological Patients
Arnon D. Cohen and Daniel A. Vardy
This article does not have an abstract.
Pages: 377-378
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LETTER TO THE EDITOR
X-Ray Treatment of Plantar Warts and the Development of Skin Carcinoma
Lisa Asmussen and Mikael Bitsch
This article does not have an abstract.
Pages: 378-379
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LETTER TO THE EDITOR
Ultraviolet Radiation Sensitivity in Vitiligo and Adjacent Normal Skin
Carol Oh, Alison Hennessy and Jonathan L. Rees
This article does not have an abstract.
Pages: 380-380
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