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Content - Volume 88, Issue 2

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IN THIS ISSUE
In this issue… PPP: What's New in the Treatment, Pathogenesis and Terminology?
Gerd Michaëlsson
Wozel & Vitéz (1) report in a letter the clearance of palmoplantar pustular psoriasis (PPP) during treatment with efalizumab. Other case reports have indicated promising results with efalizumab, but there have been no controlled studies. On the other hand, there are reports of worsening or precipitation of the disease by tumour necrosis factor (TNF)-alpha blockers, which are so useful in the trea ...
Page: 99
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Activation of Focal Adhesion Kinase in Detached Human Epidermal Cancer Cells and Their Long-term Survival Might be Associated with Cell Surface Expression of Laminin-5
Hiroshi Katayama, Yasuhiro Yamane, Yusuke Furukawa, Seiichi Kitagawa, Yukio Nakamura, Kaori Yoshino
While normal epithelial cells are anchorage-dependent, cancer cells are anchorage-independent. To elucidate the mechanism underlying the anchorage-independence of cancer cells, we cultured detached cells in medium containing elastase. Detached human epidermal cancer cells (DJM-1) survived for at least 3 weeks and focal adhesion kinase was still phosphorylated. In contrast, most detached keratinocy ...
Pages: 100-107
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Exercise-induced Sweating in Healthy Subjects as a Model to Predict a Drug’s Sweat-reducing Properties in Hyperhydrosis: a Prospective, Placebo-controlled, Double-blind Study
Ankie M. Harmsze, Marthe van Houte, Vera H.M. Deneer, Ron A. Tupker
The aim of this study was to develop a model to evaluate the efficacy of drugs with expected sweat-reducing properties in healthy subjects in order to select candidate drugs for the systemic treatment of primary generalized hyperhidrosis. A randomized, double-blind, placebo-controlled cross-over study was performed in 8 healthy subjects. Sweating was induced by exercise. The degree of sweating at ...
Pages: 108-112
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IL-6 and IL-10 Promoter Gene Polymorphisms in Psoriasis Vulgaris
Wojciech Baran, Jacek C. Szepietowski, Grzegorz Mazur, Eugeniusz Baran
Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulg ...
Pages: 113-116
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Long-term Follow-up of Cancer Risk in Patients Treated with Short-term Cyclosporine
Liisa Väkevä, Sakari Reitamo, Eero Pukkala, Seppo Sarna, Annamari Ranki
Cyclosporine increases the risk of skin and lymphoid tissue malignancies in organ transplant patients. A similar increase has been shown among psoriasis patients, but no data exist on the carcinogenic risk of cyclosporine monotherapy in skin diseases. We conducted a retrospective cohort study of 272 patients, all of whom had received at least one month of cyclosporine treatment. The cancer inform ...
Pages: 117-120
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Affective and Sensory Dimensions of Pruritus Severity: Associations with Psychological Symptoms and Quality of Life in Psoriasis Patients
Robert Zachariae, Claus C. Zachariae, Ulrikke Lei, Anette F. Pedersen
The subjective dimensions of pruritus and their associations with psychological symptoms and quality of life were explored in a sample of 40 psoriasis patients. The patients completed a scale with descriptors from the Structured Itch Questionnaire together with measures of depression, distress, sleep quality and pruritus-related quality of life. Psoriasis severity was assessed with the Psoriasis A ...
Pages: 121-127
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Itching in the Psychiatric Ward
Doron Mazeh, Yuval Melamed, Alex Cholostoy, Vadim Aharonovitzch, Abraham Weizman, Gil Yosipovitch
Chronic itch is known to have psychogenic elements; however, there is no data on itch prevalence and characteristics among hospitalized psychiatric patients. We investigated the prevalence and types of itching among hospitalized psychiatric patients who met DSM-IV criteria for schizophrenia, affective or other psychiatric disorders. A validated itch questionnaire based on the McGill Pain Questionn ...
Pages: 128-131
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Vulvar Pruritus and Burning Sensation in Women with Psoriasis
Aleksandra Zamirska, Adam Reich, Joanna Berny-Moreno, Joanna Salomon, Jacek C. Szepietowski
Approximately 80% of psoriatic individuals experience pruritus, of varying intensity. This study evaluated the frequency of vulvar itching and burning and its influence on well-being in women with psoriasis. A total of 93 women were included in the study. Psoriasis severity was assessed according to the Psoriasis Area and Severity Index, the intensity of vulvar discomfort by visual analogue scale ...
Pages: 132-135
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Holmium Laser Treatment of Genital Warts: an Observational Study of 1500 Cases
Chun-Jun Yang, Sheng-Xiu Liu, Jiang-Bo Liu, Zhong-Ying Wang, Di-Feng Luo, Guo-Long Zhang, Xue-Jun Zhang, Sen Yang
The treatment and relapse rate of genital warts are significant problems. The aim of this observational study was to assess the efficacy of holmium laser treatment of genital warts. A total of 1500 outpatients with genital human papillomavirus-induced lesions presenting from August 2002 to June 2005 were treated with holmium laser. The effects and side-effects of treatment were observed and analys ...
Pages: 136-138
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Comparison of Classical Dermatoscopy and Acrylic Globe Magnifier Dermatoscopy
Henrik F. Lorentzen, Rikke Løvendahl Eefsen, Kaare Weismann
Dermatoscopic asymmetry of melanocytic skin lesion is pivotal in most algorithms assessing the probability of melanoma. Larger lesions cannot be assessed by dermatoscopy and the Dermaphot in a single field of vision, but this can be performed using the acrylic globe magnifier. We examined the diagnostic accuracy of the acrylic globe magnifier and compared it with classical dermatoscopy. A total of ...
Pages: 139-142
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Main Problems Experienced by Children with Epidermolysis Bullosa: a Qualitative Study with Semi-structured Interviews
Corinne van Scheppingen, Ant T. Lettinga, José C. Duipmans, Carel G.B. Maathuis, Marcel F. Jonkman
The objective of this study was to identify and specify the problems of children with epidermolysis bullosa. The questions explored were: (i) What do children with epidermolysis bullosa experience as the most difficult problems; (ii) What is the impact of these problems on their daily life; and (iii) Do these experiences differ between mildly and severely affected children? Qualitative research me ...
Pages: 143-150
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Primary Subcutaneous B-cell Lymphoma: Case Report and Literature Review
Mauro Alaibac, Matteo Bordignon, Natale Pennelli, Savina Aversa, Cleto Veller Fornasa, Vanna Chiarion
This article does not have an abstract.
Pages: 151-154
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Methicillin-resistant Staphylococcus aureus in Skin Disease Affects Mainly Elderly Patients with Eczema and Leg Ulcers who have Associated Chronic Disease
Anjali Jayasekera, Lucy Jennings, Catherine R. Holden, Christine Bates, David J. Gawkrodger
This article does not have an abstract.
Pages: 156-158
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Fatal Bullous Pyoderma Gangrenosum in a Patient with Klinefelter
Angelo Valerio Marzano, Valentina Trevisan, Chiara Galloni, Elvio Alessi
This article does not have an abstract.
Pages: 158-159
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Cutaneous Phaeohyphomycosis Caused by Alternaria infectoria
Jochen Brasch, Jan-Ole Busch, G. Sybren de Hoog
This article does not have an abstract.
Pages: 160-161
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Cardiac Tamponade in a Patient with Predominantly Cutaneous Manifestations of Primary Antiphospholipid Syndrome
Jussi Liippo, Pekka Taimen, Lauri Talve, Riitta Saario, Eeva Vainio
This article does not have an abstract.
Pages: 162-162
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Epidermotropic Metastases with Trans-epidermal Elimination from Breast Carcinoma
Akemi Ohnishi, Yuichi Yoshida, Kazuhiko Hayashi, Osamu Yamamoto
This article does not have an abstract.
Pages: 164-165
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Poroma with Sebaceous Differentiation of the Eyelid: a Rare Site of Occurrence
Junya Iwasaki, Yuichi Yoshida, Osamu Yamamoto, Shingo Tajima
This article does not have an abstract.
Pages: 166-167
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Dysphonia Revealing Early Syphilis
Nicolas Kluger, Jean Lacau Saint-Guily, Sélim Aractingi
This article does not have an abstract.
Pages: 167-168
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Palmoplantar Pustular Psoriasis: Successful Therapy with Efalizumab after Non-response to Infliximab
Gottfried Wozel, Lilla Vitez
This article does not have an abstract.
Pages: 169-170
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Palpable Archiform Migratory Erythema Preceded by B-cell Pseudolymphoma in a Japanese Man
Hiroaki Yagi, Taisuke Ito, Natsuho Ito, Takahiro Horibe, Yasushi Yoshinari, Masahiro Takigawa, Hideo Hashizume
This article does not have an abstract.
Pages: 171-172
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A Case of Discoid Lupus Erythematosus Masquerading as Acne
Anastasio Stavrakoglou, Jenny Hughes, Ian Coutts
This article does not have an abstract.
Pages: 175-176
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A Severe Case of Ulcerating Necrobiosis Lipoidica
Tina Rask Elmholdt, Hanne Birke Sørensen, Karsten Fogh
This article does not have an abstract.
Pages: 177-178
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Clinical and Aetiopathogenic Characteristics and Prevalence of Panniculitis in Turkey: A Retrospective Clinical Study
Ülker Gül, Müzeyyen Gönül, Özlem Demirel Ekiz, Seray Külcü Çakmak
This article does not have an abstract.
Pages: 179-180
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A Recurrent Case of Targetoid Hemosiderotic Haemangioma
Cheng Tan, Wen-Yuan Zhu, Ren-Sheng Lai
This article does not have an abstract.
Pages: 181-182
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Atypical Cutaneous Tuberculosis in a Patient with Rheumatoid Arthritis Treated with Infliximab
Yusuke Asano, Yoko Kano, Tetsuo Shiohara
This article does not have an abstract.
Pages: 183-184
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Regression of Cutaneous Squamous Cell Carcinoma in a Patient with Chronic Myeloid Leukaemia on Imatinib Mesylate Treatment
Yoshio Kawakami, Koichiro Nakamura, Akiko Nishibu, Hirokatsu Yanagihori, Hideo Kimura, Toshiyuki Yamamoto
This article does not have an abstract.
Pages: 185-186
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Chlamydia trachomatis in the Throat: Is Testing Necessary?
Helena Carré, Anne-Christine Edman, Jens Boman, Elisabet Nylander
This article does not have an abstract.
Pages: 187-188
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Identification of Cowpox Infection in a 13-year-old Danish Boy
Louise Vestergaard, Lasse Vinner, Klaus E. Andersen, Anders Fomsgaard
This article does not have an abstract.
Pages: 188-190
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Skin Hyperpigmentation and Increased Angiogenesis Secondary to Vitamin B12 Deficiency in a Young Vegetarian Woman
Kyriaki Aroni, Konstantina Anagnostopoulou, Eugenia Tsagroni, Eleftherios Ioannidis
This article does not have an abstract.
Pages: 191-192
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Kasabach-Merritt Syndrome Associated with Angiosarcoma of the Scalp Successfully Treated with Chemoradiotherapy
Shinichi Imafuku, Chisato Hosokawa, Yoichi Moroi, Masutaka Furue
This article does not have an abstract.
Pages: 193-194
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Allergic Drug Eruption Secondary to Intravenous Acyclovir
Jan Schuster, Mario Fabri, Sabine Eming, Nicolas Hunzelmann
This article does not have an abstract.
Pages: 196-198
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LETTER TO THE EDITOR
"Extra-edge Effect": A Further Problem in Patch Test Diagnosis?
Monica Corazza, Federica Osti, Lucia Mantovani, Annarosa Virgili
Abstract is missing (Letter)
Pages: 198-199
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LETTER TO THE EDITOR
Etoricoxib-induced Acute Generalized Exanthematous Pustulosis
Leeni Mäkelä, Kaija Lammintausta
Abstract is missing (Letter)
Pages: 200-201
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LETTER TO THE EDITOR
Chronic Genital Ulceration due to Herpes Simplex Infection Treated Successfully with Imiquimod
Nannie Bangsgaard, Lone Skov
Abstract is missing (Letter)
Pages: 202-203
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LETTER TO THE EDITOR
Decreased Hydrosoluble Antioxidant Capacity in Women: Comment on the Paper by Guarrera & Rebora on Polymorphic Light Eruption
Roberta Giardini, Pasquale P. Cardo
Abstract is missing (Letter)
Pages: 204-204
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Commentary: Question about the English in Acta Dermato-Venereologica
This article does not have an abstract.
Page: 205
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