Content - Volume 88, Issue 216

Editors choice in this issue

All articles

Chapter 1. Fusidic acid: a valuable agent for controlling Staphylococcus aureus skin infections
Staphylococcus aureus is a key pathogen in skin and soft-tissue infections, and controlling it is crucial in treating these conditions. The principal antibiotics used for ambulatory treatment of S. aureus skin infections are beta-lactams, macrolides, aminoglycosides, tetracyclines, mupirocin and fusidic acid. In choosing an antibiotic, ideally the following characteristics should be met: adequate ...
Pages: 7-13
Abstract  PDF
Chapter 2. Fusidic acid in skin and soft-tissue infections
Barry H. Long
"Topical antibacterial therapy is an important component in managing skin and soft-tissue infections (SSTIs). Fusi­dic acid, a narrow-spectrum antibiotic active against Staphylococcus aureus, has shown good skin permeability and low allergenic potential. The resistance rate in S. aureus remains low, as shown in a study of Canadian hospitals from 1999 to 2005. In treating primary skin infectio ...
Pages: 14-20
Abstract  PDF
Chapter 3. The role of Staphylococcus aureus in atopic eczema
"Staphylococcus aureus infection plays an important role in atopic eczema (AE) because of its ability to produce virulence factors such as superantigens. Epicutaneous application of superantigens induces eczema. Super­antigens also induce corticosteroid resistance, and subvert T-regulatory cell activity, thereby increasing AE severity. Increased binding of S. aureus to skin is driven by underlyin ...
Pages: 21-27
Abstract  PDF
Chapter 4. Antibacterial/steroid combination therapy in infected eczema
"Infection with Staphylococcus aureus is common in all forms of eczema. Production of superantigens by S. ­aureus increases skin inflammation in eczema; antibacterial treatment is thus pivotal. Poor patient compliance is a major cause of treatment failure; combination preparations that contain an antibacterial and a topical steroid and that work quickly can improve compliance and thus treatment ...
Pages: 28-34
Abstract  PDF
Chapter 5. Treatment success factors: diagnostic and treatment choices, and patient education
In eczema, many factors influence treatment success. This interactive session included discussion of two case histories, illustrating the range of diagnostic procedures and treatment options available in eczema, and the variety of solutions that individual clinicians might choose. When inflammation and infection are both present, a topical treatment that combines anti-inflammatory and anti-infecti ...
Pages: 35-39
Abstract  PDF