Content

Content - Volume 99, Issue 2

Editor's choice in this issue

REVIEW
Effect of Diet in Chronic Spontaneous Urticaria: A Systematic Review
Hélène Cornillier, Bruno Giraudeau, Mahtab Samimi, Stéphane Munck, Florence Hacard, Annie-Pierre Jonville-Bera, Marie-Hélène Jegou, Gwenaëlle d'Acremont, Bach-nga Pham, Olivier Chosidow, Annabel Maruani
Strategies for diets are controversial in chronic spontaneous urticaria (CSU). We performed a systematic review to assess the value of diets in managing CSU. The review shows that the level of scientific evidence is low because controlled studies of diets and of allergological tests in chronic spontaneous urticaria are lacking. However, the data suggest no benefit of systematic diets in chronic spontaneous urticaria, but benefit of personalized diets in individual patients with clinical symptoms.
Pages: 127-132
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INVESTIGATIVE REPORT
The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization
Lorenzo Pasquali, Ankit Srivastava, Florian Meisgen, Kunal Das Mahapatra, Ping Xia, Ning Xu Landén, Andor Pivarcsi, Enikö Sonkoly
Psoriasis is a common immune-mediated disease resulting from altered cross-talk between keratinocytes and immune cells. Previous transcriptomic studies have identified thousands of deregulated genes in psoriasis skin; however, the transcriptomic changes confined to the epidermal compartment remained poorly characterized. The aim of this study was to characterize the transcriptomic landscape of pso ...
Pages: 196-205
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All articles

REVIEW
Effect of Diet in Chronic Spontaneous Urticaria: A Systematic Review
Hélène Cornillier, Bruno Giraudeau, Mahtab Samimi, Stéphane Munck, Florence Hacard, Annie-Pierre Jonville-Bera, Marie-Hélène Jegou, Gwenaëlle d'Acremont, Bach-nga Pham, Olivier Chosidow, Annabel Maruani
Strategies for diets in chronic spontaneous urticaria (CSU) are controversial. This systematic review assessed the interest in diet for managing CSU. We searched for original reports in MEDLINE, EMBASE, CENTRAL and LILACS. Among the 278 reports screened, 20 were included, involving 1,734 patients. Reports described 3 types of systematic diet: pseudoallergen-free diet (n = 1,555 patients), low- ...
Pages: 127-132
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REVIEW
Digital Education for Health Professions in the Field of Dermatology: A Systematic Review by Digital Health Education Collaboration
Xiaomeng Xu, Pawel Przemyslaw Posadzki, Grace E. Lee, Josip Car, Helen Elizabeth Smith
Digital health education is a new approach that is receiving increasing attention with advantages such as scalability and flexibility of education. This study employed a Cochrane review approach to assess the evidence for the effectiveness of health professions’ digital education in dermatology to improve knowledge, skills, attitudes and satisfaction. Twelve trials (n = 955 health profession ...
Pages: 133-138
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CLINICAL REPORT
Increase in Vitamin D but not Regulatory T Cells following Ultraviolet B Phototherapy of Patients with Atopic Dermatitis
Stine Simonsen, Charlotte M. Bonefeld, Jacob P. Thyssen, Carsten Geisler, Lone Skov
This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. ...
Pages: 139-145
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CLINICAL REPORT
Occurrence, Chronicity and Intensity of Itch in a Clinical Consecutive Sample of Patients with Skin Diseases: A Multi-centre Study in 13 European Countries
Christina Schut, Florence J. Dalgard, Jon Anders Halvorsen, Uwe Gieler, Lars Lien, Lucía Tomas Aragones, Françoise Poot, Gregor B. E. Jemec, Laurent Misery, Lajos Kemény, Francesca Sampogna, Henriët van Middendorp, Flora Balieva, Dennis Linder, Jacek C. Szepietowski, Andrey Lvov, Servando E. Marron, Ilknur K. Altunay, Andrew Y. Finlay, Sam Salek, Jörg Kupfer
Itch is an unpleasant symptom, affecting many dermatological patients. Studies investigating the occurrence and intensity of itch in dermatological patients often focus on a single skin disease and omit a control group with healthy skin. The aim of this multi-centre study was to assess the occurrence, chronicity and intensity (visual analogue scale 0–10) of itch in patients with different skin d ...
Pages: 146-151
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CLINICAL REPORT
Nail Involvement as a Predictor of Disease Severity in Paediatric Psoriasis: Follow-up Data from the Dutch ChildCAPTURE Registry
Inge M.G.J. Bronckers, Finola M. Bruins, Maartje J. van Geel, Hans M.M. Groenewoud, Wietske Kievit, Peter C.M. van de Kerkhof, Marcel C. Pasch, Elke M.G.J. de Jong, Marieke M.B. Seyger
Little is known about the relationship between nail psoriasis and psoriasis severity in children, and there has been no longitudinal assessment of psoriasis severity related to nail psoriasis. The aim of this study was to assess whether nail psoriasis could serve as a predictor for a more severe disease course. De-identified data were obtained from the ChildCAPTURE registry, a daily clinical pract ...
Pages: 152-157
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CLINICAL REPORT
The Importance of Achieving Clear or Almost Clear Skin for Patients: Results from the Nordic Countries of the Global "Clear about Psoriasis" Patient Survey
Mads Kirchheiner Rasmussen, Martin Enger, Anna-Karin Dahlborn, Siri Juvik, Laura Fagerhed, Rikke Dodge, Charlotta Enerbäck
Psoriasis is a stigmatizing chronic skin condition in which impairment of quality of life is associated with visibility of skin lesions, disease activity and severity. The ultimate goal of treatment is complete clearance of skin symptoms. The worldwide “Clear About Psoriasis” survey explored patients’ perspectives on clear/almost clear skin and the impact of psoriasis on daily life. We repor ...
Pages: 158-163
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CLINICAL REPORT
Ultrasound Assessment of Psoriatic Onychopathy: A Cross-sectional Study Comparing Psoriatic Onychopathy with Onychomycosis
Mireia Moreno, Maria Pilar Lisbona, Fernando Gallardo, Gustavo Deza, Marta Ferran, Caridad Pontes, Jesús Luelmo, Joan Maymó, Jordi Gratacós
This cross-sectional study evaluated the usefulness of an ultrasound technique in assessment of nail changes in 35 patients with psoriatic onychopathy and 25 with nail dystrophy secondary to onychomycosis. All patients underwent 3 examinations: a complete clinical assessment; a nail ultrasound study; and fungal culture. Nails of patients with psoriatic onychopathy presented a thinner nail plate an ...
Pages: 164-169
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CLINICAL REPORT
Prevalence and Clinical Characteristics of Cutaneous Manifestations Associated with Bacteraemia: A Cross-sectional Prospective Study
Hélène Taquin, Thomas Hubiche, Laurent Roudière, Agnès Fribourg, Pascal Del Giudice
Bacteraemias are life-threatening conditions that require rapid care and antibiotherapy. Dermatological signs might help in deciding the most relevant treatment. The aim of this study was to determine the prevalence and clinical characteristics of cutaneous manifestations in hospitalized patients with bacteraemia. A cross-sectional study was conducted over a period of 1 year. All consecutive patie ...
Pages: 170-174
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CLINICAL REPORT
Influence of Itch and Pain on Sleep Quality in Atopic Dermatitis and Psoriasis
Karolina Kaaz, Jacek C. Szepietowski, Łukasz Matusiak
Subjective symptoms accompanying atopic dermatitis and psoriasis can negatively influence patients’ well-being. This study assessed the impact of itch and pain on sleep quality among 100 patients with atopic dermatitis and 100 patients with psoriasis, compared with 50 controls. The Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate a spectrum of sleep dis ...
Pages: 175-180
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INVESTIGATIVE REPORT
Staphylococcus epidermidis-induced Interleukin-1 Beta and Human Beta-defensin-2 Expression in Human Keratinocytes is Regulated by the Host Molecule A20 (TNFAIP3)
Maren Simanski, Anna-Sophie Erkens, Franziska Rademacher, Jürgen Harder
Staphylococcus epidermidis is an abundant skin commensal capable of activating cutaneous defense responses, such as induction of cytokines and antimicrobial peptides. To permanently colonize human skin and prevent inflammation S. epidermidis needs to control the induction of host defense mediators. We report here that S. epidermidis induces expression of the host regulator protein A20 in human ker ...
Pages: 181-187
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INVESTIGATIVE REPORT
Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch
Zoe Lewis, David N. George, Fiona Cowdell, Henning Holle
While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. ...
Pages: 188-195
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INVESTIGATIVE REPORT
The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization
Lorenzo Pasquali, Ankit Srivastava, Florian Meisgen, Kunal Das Mahapatra, Ping Xia, Ning Xu Landén, Andor Pivarcsi, Enikö Sonkoly
Psoriasis is a common immune-mediated disease resulting from altered cross-talk between keratinocytes and immune cells. Previous transcriptomic studies have identified thousands of deregulated genes in psoriasis skin; however, the transcriptomic changes confined to the epidermal compartment remained poorly characterized. The aim of this study was to characterize the transcriptomic landscape of pso ...
Pages: 196-205
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INVESTIGATIVE REPORT
Early Circulating Tumour DNA Variations Predict Tumour Response in Melanoma Patients Treated with Immunotherapy
Laura Keller, Nicolas Guibert, Anne Casanova, Stephanie Brayer, Magali Farella, Myriam Delaunay, Julia Gilhodes, Elodie Martin, Gisèle Balagué, Gilles Favre, Anne Pradines, Nicolas Meyer
Antibodies targeting immune checkpoints were recently approved for metastatic melanoma. However, not all patients will respond to the treatment and some will experience grade III–IV immune-related adverse events. Therefore, early identification of non-responder patients would greatly aid clinical practice. Detection of circulating tumour DNA (ctDNA) is a non-invasive approach to monitor tumour r ...
Pages: 206-210
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INVESTIGATIVE REPORT
Measuring Patient Needs and Benefits in Dermatology using the Patient Benefit Index 2.0: A Validation Study
Janine Topp, Matthias Augustin, Kathrin von Usslar, Ramona Gosau, Kristian Reich, Michael Reusch, Christine Blome
This study investigated the validity and feasibility of the Patient Benefit Index 2.0 (PBI 2.0), a short instrument to assess patient-relevant treatment benefit. In a cross-sectional study, patients with skin diseases completed the PBI 2.0 alongside instruments on quality of life and disease-specific PBI long versions to assess convergent validity. Feasibility questions appraise comprehensibility, ...
Pages: 211-217
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SHORT COMMUNICATION
Blaschkolinear Lichen Planus Pigmentosus in the Setting of Chronic Graft-versus-host Disease
Caterina Pinzani, Jean-David Bouaziz
Abstract is missing (Short communication)
Pages: 218-219
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SHORT COMMUNICATION
Pruritus in Chronic Liver Disease: A Questionnaire Survey on 216 Patients
Makiko Kido-Nakahara, Takeshi Nakahara, Norihiro Furusyo, Shinji Shimoda, Kazuhiro Kotoh, Masaki Kato, Jun Hayashi, Toshimasa Koyanagi, Masutaka Furue
Abstract is missing (Short communication)
Pages: 220-221
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SHORT COMMUNICATION
Assessing Punctate Administration of Beta-alanine as a Potential Human Model of Non-histaminergic Itch
Janne D. Christensen, Silvia Lo Vecchio, Jesper Elberling, Lars Arendt-Nielsen, Hjalte H. Andersen
Abstract is missing (Short communication)
Pages: 222-223
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SHORT COMMUNICATION
Unmet Needs in Pemphigoid Diseases: An International Survey Amongst Patients, Clinicians and Researchers
Aniek Lamberts, Marc Yale, Sergei A. Grando, Barbara Horváth, Detlef Zillikens, Marcel F. Jonkman
Abstract is missing (Short communication)
Pages: 224-225
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SHORT COMMUNICATION
Aberrant B-cell Subsets and Immunoglobulin Levels in Patients with Moderate-to-severe Psoriasis
Katrin Kahlert, Franziska Grän, Khalid Muhammad, Sandrine Benoit, Edgar Serfling, Matthias Goebeler, Andreas Kerstan
Abstract is missing (Short communication)
Pages: 226-227
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SHORT COMMUNICATION
Two Cases of Acute Febrile Neutrophilic Dermatosis Thought to be Caused by Topical Clindamycin
Kiriko Nitta, Yoko Kano, Yukiko Ushigome, Jun Hayakawa, Tetsuo Shiohara
Abstract is missing (Short Communication)
Pages: 228-229
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SHORT COMMUNICATION
A Case of Perforating Folliculitis Induced by Vemurafenib
Ken Shiraishi, Tae Masunaga, Mikiko Tohyama, Koji Sayama
Abstract is missing (Short Communication)
Pages: 230-231
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SHORT COMMUNICATION
Induced Vitiligo due to Talimogene Laherparepvec Injection for Metastatic Melanoma Associated with Long-term Complete Response
Pablo Iglesias, Simone Ribero, Alicia Barreiro, Sebastian Podlipnik, Cristina Carrera, Josep Malvehy, Susana Puig
Abstract is missing (Short Communication)
Pages: 232-233
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SHORT COMMUNICATION
Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report
Evy Paulsen, Anette Bygum
Abstract is missing (Short communication)
Pages: 234-235
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SHORT COMMUNICATION
Large-scale Retrospective Cohort Study of Psychological Stress in Patients with Alopecia Areata According to the Frequency of Intralesional Steroid Injection
Shinwon Hwang, Jaeyong Shin, Tae-Gyun Kim, Do-Young Kim, Sang Ho Oh
Abstract is missing (Short communication)
Pages: 236-237
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SHORT COMMUNICATION
Phenotypic Features of Epidermolysis Bullosa Simplex due to KLHL24 Mutations in 3 Italian Cases
May El Hachem, Sabina Barresi, Andrea Diociaiuti, Renata Boldrini, Angelo Giuseppe Condorelli, Ettore Capoluongo, Vittoria Proto, Giulietta Scuvera, Cristina Has, Marco Tartaglia, Daniele Castiglia
Abstract is missing (Short Communication)
Pages: 238-239
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SHORT COMMUNICATION
Skin Lesions Suggesting Type 2 Segmental Mosaicism in Noonan Syndrome
Rudolf Happle
Abstract is missing (Short communication)
Pages: 240-241
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SHORT COMMUNICATION
Pulse–Daylight–Photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial
Stine R. Wiegell, Urs B. Johansen, Hans Christian Wulf
Abstract is missing (Short communication)
Pages: 242-243
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SHORT COMMUNICATION
A Case of Generalized Interstitial Granuloma Annulare and Arthritis Associated with Breast Cancer
Ariane Clapé, Clélia Vanhaecke, Anne Durlach, Philippe Bernard, Christelle Jouannaud, Laurie Kpodar, Bernard Cribier, Manuelle Viguier
Abstract is missing (Short Communication)
Pages: 244-245
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SHORT COMMUNICATION
Porokeratosis Ptychotropica on the Penis and Scrotum: A Case Report
Yue-Tong Qian, Sergio Vano-Galvan, Jia-Wei Liu, Wei Liu, Dong-Lai Ma
Abstract is missing (Short communication)
Pages: 246-247
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SHORT COMMUNICATION
Perception of Dermatology and Dermatologists Among Medical Students
Laine Ludriksone, Jörg Tittelbach, Peter Elsner
Abstract is missing (Short Communication)
Pages: 248-249
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QUIZ
Fast-growing Painful Leg Ulcers in a 26-year-old Woman with Systemic Lupus Erythematosus: A Quiz
Julia Hartmann, Holger A. Haenssle, Alexander H. Enk, Ferdinand Toberer
Abstract is missing (Quiz)
Pages: 250-252
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QUIZ
Rashes, Erosions and Purulent Fluid in the Intertriginous Areas: A Quiz
Yonghu Sun, Furen Zhang
Abstract is missing (Quiz)
Pages: 253-254
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