Content » Vol 43, Issue 8

Original report

Left-ventricular function and autonomic cardiac adaptations after short-term inpatient cardiac rehabilitation: A prospective clinical trial

Renata G. Mendes, Rodrigo P. Simões, Fernando de Souza Melo Costa, Camila Bianca Falasco Pantoni, Luciana Di Thommazo, Sérgio Luzzi, Othon Amaral-Neto, Aparecida Maria Catai, Ross Arena, Audrey Borghi-Silva
DOI: 10.2340/16501977-0843


Objective: Cardiac rehabilitation is associated with cardiac autonomic and physiological benefits. However, it is unclear whether baseline left ventricular function (LVF) impacts on training-induced cardiac autonomic adaptations. The aim of this study was to assess the cardiac autonomic adaptations in patients with varying left ventricular function profiles undergoing coronary artery bypass grafting and cardiac rehabilitation.
Design: Assessor-blinded prospective trial.
Patients: Forty-four patients undergoing coronary artery bypass grafting, divided into normal LVFN (≥ 55%, n = 23) or reduced LVFR (35–54%, n = 21) were evaluated.
Method: Cardiac autonomic function was evaluated by heart rate variability indexes obtained both pre- and post-cardiac rehabilitation. All patients participated in a short-term (approximately 5 days) supervised inpatient physiotherapy program.
Results: There were differences in heart rate variability indexes, correlation dimension and SD2 according to time and group (e.g. interaction time (effect of cardiac rehabilitation) vs group (LVFN vs LVFR), p = 0.04). Simple main effects analysis showed that the LVFR group benefited to a greater degree from cardiac rehabilitation compared with the LVFN group. Heart rate variability indexes increased significantly in the former group compared with the latter.
Conclusion: Among post-coronary artery bypass grafting patients engaged in short-term inpatient rehabilitation, those with reduced left ventricular function are most likely to have better cardiac autonomic adaptations to exercise-based rehabilitation.

Lay Abstract


Do you want to comment on this paper? The comments will show up here and if appropriate the comments will also separately be forwarded to the authors. You need to login/create an account to comment on articles. Click here to login/create an account.