Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: Results from the Amsterdam Osteoarthritis cohort
Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Jasmijn Holla, Leo D. Roorda, Willem Lems, Joost Dekker
Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands. E-mail: tomaszcudejko@gmail.com
DOI: 10.2340/16501977-2272
Lay Abstract
It is not known why higher level of systemic inflammation is related to muscle weakness in persons with knee osteoarthritis. We hypothesized that proprioception, one’s ability to detect joint movement and position, might be a factor explaining the relationship between systemic inflammation and muscle weakness. We analyzed the data from 689 participants from the Amsterdam Osteoarthritis cohort. As expected, higher levels of systemic inflammation were associated with muscle weakness, and this relation was partly explained by poor proprioception. These results suggest that poor proprioception is indeed one of the factors that explain the relationship between systemic inflammation and muscle weakness in persons with knee osteoarthritis.
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