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Investigative Report

Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

doi: 10.2340/00015555-1231

Abstract:

Optical coherence tomography (OCT) is a new imaging method with promising results for several dermatological indications, including preoperative skin tumour characterization. While high-frequency ultrasound (HFUS) is frequently used for this purpose, overestimation of tumour thickness is a problem, due to subtumoral inflammatory infiltration that cannot be differentiated from tumour tissue. The aim of this single-centre study was to describe OCT features of basal cell carcinoma (BCC) and to determine vertical tumour thickness accurately, including a comparison with HFUS and histopathology. Tumour thickness values of 10 BCCs measured by OCT did not differ significantly from those measured by histopathology (median difference 0.12 mm). By contrast, the difference between HFUS and histopathology was greater (median difference 0.3 mm). A Pearson’s correlation coefficient of 0.83 showed a stronger correlation of OCT in measuring tumour thickness compared with HFUS (0.59). Bland-Altman plots revealed a better agreement of OCT and histopathology concerning tumour thickness measurements. On the basis of this explorative study cohort, OCt was more exact than HFUS in preoperative tumour thickness estimation of BCCs compared with histopathological measurements.

Authors:

Torsten Hinz, Lin-Kristin Ehler, Thorsten Hornung, Harald Voth, Ines Fortmeier, Tania Maier, Tobias Höller, Monika H. Schmid-Wendtner

References

  • Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nat Clin Pract Oncol 2007; 4: 462–469.
  • Diepgen TL. Epidemiology of chronic UV-damage. J Dtsch Dermatol Ges 2005; 3: 32–35.
  • Tillman DK Jr, Carroll MT. A 36-month clinical experience of the effectiveness curettage and imiquimod 5% cream in the treatment of basal cell carcinoma. J Drugs Dermatol 2008; 7: 7–14.
  • Wagstaff AJ, Perry CM. Topical imiquimod: a review of its use in the management of anogenital warts, actinic keratoses, basal cell carcinoma and other skin lesions. Drugs 2007; 67: 2187–2210.
  • Surrenti T, De Angelis L, Di Cesare A, Fargnoli MC, Peris K. Efficacy of photodynamic therapy with methyl aminolevulinate in the treatment of superficial and nodular basal cell carcinoma: an open-label trial. Eur J Dermatol 2007; 17: 412–415.
  • Mogensen M, Jemec GB. Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologies. Dermatol Surg 2007; 33: 1158–1174.
  • Marmur ES, Berkowitz EZ, Fuchs BS, Singer GK, Yoo JY. Use of high-frequency, high-resolution ultrasound before Mohs surgery. Dermatol Surg 2010; 36: 841–847.
  • Jambusaria-Pahlajani A, Schmults CD, Miller CJ, Shin D, Williams J, Kurd SK, et al. Test characteristics of high-resolution ultrasound in the preoperative assessment of margins of basal cell and squamous cell carcinoma in patients undergoing Mohs micrographic surgery. Dermatol Surg 2009; 35: 9–15.
  • Petrella LI, Valle HA, Issa PR, Martins CJ, Pereira WC, Machado JC. Study of cutaneous cell carcinomas ex vivo using ultrasound biomicroscopic images. Skin Res Technol 2010; 16: 422–424.
  • Machet L, Belot V, Naouri M, Boka M, Mourtada Y, Giraudeau B, et al. Preoperative Measurement of thickness of cutaneous melanoma using high-resolution 20 MHz ultrasound imaging: a monocenter prospective study and systematic review of the literature. Ultrasound Med Biol 2009; 35: 1411–1420.
  • Vilana R, Puig S, Sanchez M, Squarcia M, Lopez A, Castel T, Malvehy J. Preoperative assessment of cutaneous melanoma thickness using 10-MHz sonography. Am J Roentgenol 2009; 193: 639–643.
  • Bessoud B, Lassau N, Koscielny S, Longvert C, Avril MF, Duvillard P, et al. High-frequency sonography and color Doppler in the management of pigmented skin lesions. Ultrasound Med Biol 2003; 29: 875–879.
  • Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science 1991; 254: 1178–1181.
  • Fujimoto JG. Optical coherence tomography for ultrahigh resolution in vivo imaging. Nat Biotechnol 2003; 21: 1361–1367.
  • Welzel J, Lankenau E, Birngruber R, Engelhardt R. Optical coherence tomography of the human skin. J Am Acad Dermatol 1997; 37: 958–963.
  • Gladkova ND, Petrova GA, Nikulin NK, Radenska-Lopovok SG, Snopova LB, Chumakov YP, et al. In vivo optical coherence tomography imaging of human skin: norm and pathology. Skin Res Technol 2000; 6: 6–16.
  • Gambichler T, Orlikov A, Vasa R, Moussa G, Hoffmann K, Stücker M, et al. In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 2007; 45: 167–173.
  • Strasswimmer J, Pierce MC, Park BH, Neel V, de Boer JF. Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma. J Biomed Opt 2004; 9: 292–298.
  • Gambichler T, Regeniter P, Bechara FG, Orlikov A, Vasa R, Moussa G, et al. Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo. J Am Acad Dermatol 2007; 57: 629–637.
  • Wang T, Mallidi S, Qiu J, Ma LL, Paranjape AS, Sun J, et al. Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms. J Biophotonics 2011; 4: 335–344.
  • Mogensen M, Nürnberg BM, Forman JL, Thomsen JB, Thrane L, Jemec GB. In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasound. Br J Dermatol 2009; 160: 1026–1033.
  • Desai TD, Desai AD, Horowitz DC, Kartono F, Wahl T. The use of high-frequency ultrasound in the evaluation of superficial and nodular basal cell carcinomas. Dermatol Surg 2007; 33: 1226–1227.
  • Bobadilla F, Wortsman X, Muñoz C, Segovia L, Espinoza M, Jemec GB. Presurgical high resolution ultrasound of facial basal cell carcinoma: correlation with histology. Cancer Imaging 2008; 8: 163–172.
  • Ruocco E, Argenziano G, Pellacani G, Seidenari S. Noninvasive imaging of skin tumors. Dermatol Surg 2004; 30: 301–310.
  • Moore JV, Allan E. Pulsed ultrasound measurements of depth and regression of basal cell carcinomas after photodynamic therapy: relationship to probability of 1-year local control. Br J Dermatol 2003; 149: 1035–1040.
  • Gupta AK, Turnbull DH, Foster FS, Harasiewicz KA, Shum DT, Prussick R, et al. High frequency 40-MHz ultrasound. A possible non-invasive method for the assessment of the boundary of basal cell carcinomas. Dermatol Surg 1996; 22: 131–136.
  • Gambichler T, Moussa G, Sand M, Sand D, Altmeyer P, Hoffmann K. Applications of optical coherence tomography in dermatology. J Dermatol Sci 2005; 40: 85–94.
  • Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL. Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study. Dermatol Surg 2007; 33: 421–425.
  • Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL. Optical coherence tomography fort he characterization of basal cell carcinoma in vivo: a pilot study. J Am Acad Dermatol 2006; 55: 408–412.
  • Bechara FG, Gambichler T, Stücker M, Orlikov A, Rotterdam S, Altmeyer P, Hoffmann K. Histomorphologic correlation with routine histology and optical coherence tomography. Skin Res Technol 2004; 10: 169–173.
  • Mogensen M, Joergensen TM, Nürnberg BM, Morsy HA, Thomsen JB, Thrane L, et al. Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 2009; 35: 965–972.
  • Salmhofer W, Rieger E, Soyer HP, Smolle J, Kerl H. Influence of skin tension and formalin fixation on sonographic measurement of tumor thickness. J Am Acad Dermatol 1996; 34: 34–39.
  • Khandwala M, Penmetsa BR, Dey S, Schofield JB, Jones CA, Podoleanu A. Imaging of periocular basal cell carcinoma using en face optical coherence tomography: a pilot study. Br J Ophthalmol 2010; 94: 1332–1336.
  • Mogensen M, Jørgensen TM, Thrane L, Nürnberg BM, Jemec GB. Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reduction. Exp Dermatol 2010; 19: 293–295.
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    Volume 92, Issue 2

    DOI: 10.2340/00015555-1231

    Pages: 132-137

    View at PubMed