Content

Content - Volume 101, August

Editor's choice in this issue

CLINICAL REPORT
Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: a 28-year Retrospective Study
Susan J. Robertson, Elizabeth Orrin, Manpreet K. Lakhan, Gavin O’Sullivan, Jessie Felton, Alistair Robson, Danielle T. Greenblatt, Catina Bernardis, John A. McGrath, Anna E. Martinez, Jemima E. Mellerio
This report details almost 3 decades experience of the London epidermolysis bullosa (EB) reference centres of cutaneous squamous cell carcinomas (SCCs). The case series of 221 primary tumours from 44 individuals reiterates that this is a complication seen not just in severe recessive dystro­phic EB (RDEB-S), but also in other EB subtypes, albeit at a later age, highlighting the need for awareness and surveillance. Most individuals developed multiple SCCs with a tendency for aggressive behaviour, despite surgical excision. The median survival of just 2.4 years after diagnosis of initial SCC in RDEB-S is lower than in previously reported smaller series, and points to the need for more effective thera­pies. Although conventional treatments such as chemotherapy or radiotherapy appear generally limited in terms of survival benefit, newer targeted therapies such as cemiplimab may hold some potential.
Pages: 1-8
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All articles

QUIZ
An Oral Blood-filled Blister: A Quiz
Jan Bajtek, Agnieszka Studniarek, Radomir Reszke, Łukasz Matusiak, Jacek C. Szepietowski
Abstract is missing (Quiz)
Pages: 1-2
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QUIZ
Blisters and Crusts on the Dorsum of the Hands: A Quiz
Benjamin Klein, Jan Christoph Simon, Konstantin Dumann, Regina Treudler
Abstract is missing (Quiz)
Pages: 1-3
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INVESTIGATIVE REPORT
A Deep Learning Approach for Histopathological Diagnosis of Onychomycosis: Not Inferior to Analogue Diagnosis by Histopathologists
Florence Decroos, Sebastian Springenberg, Tobias Lang, Marc Päpper, Antonia Zapf, Dieter Metze, Volker Steinkraus, Almut Böer-Auer
Onychomycosis is common. Diagnosis can be confirmed by various methods; a commonly used method is the histological examination of nail clippings. A deep learning system was developed and its diagnostic accuracy compared with that of human experts. A dataset with annotations for fungal elements was used to train an artificial intelligence (AI) model. In a second dataset (n=199) the diagnostic accur ...
Pages: 1-8
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QUIZ
Pruritic Erythematous Macules in a Patient with Systemic Sarcoidosis: A Quiz
Astrid Herzum, Mattia Fabio Molle, Emanuele Cozzani, Martina Burlando, Pietro Paolo Tavilla, Claudia Micalizzi, Ilaria Trave, Aurora Parodi
Abstract is missing (Quiz)
Pages: 1-2
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QUIZ
Petechial Purpura on the Lower Legs: A Quiz
Benjamin Klein, Kristin Küpper, Jan Christoph Simon
Abstract is missing (Quiz)
Pages: 1-2
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CLINICAL REPORT
Quality of Life in Hidradenitis Suppurativa: validation of the HSQoL-24
Servando E. Marron, Manuel Gomez-Barrera, Lucía Tomas Aragones, Ana Goni-Navarro, Eva Vilarrasa-Rull, Rosa María Diaz-Diaz, Francisco Javier Garcia-Latasa de Aranibar, Ricardo Campos-Rodenas, Victoria Fuentelsaz del Barrio, Yolanda Gilaberte-Calzada, Tamara Gracia-Cazaña, Anna María Morales-Callaghan, Sandra Ros-Abarca, María Blanca Madrid-Alvarez, Lluís Puig
To date, there are no disease-specific instruments in Spanish to assess quality of life of patients with hidradenitis suppurativa. A multicentre study was previously carried out in Spain between 2016 and 2017 to develop the Hidradenitis Suppurativa Quality of Life-24 (HSQoL-24), a disease-specific questionnaire to assess quality of life in patients with hidradenitis suppurativa. The objectiv­es o ...
Pages: 1-5
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CLINICAL REPORT
Trends in Kaposi’s Sarcoma Morbidity: A Retrospective Cohort Study of Heart and Lung Transplant Recipients
Tal Serlin, Tuvia Ben Gal, Mordechai R. Kramer, Diana Sorin, Emmilia Hodak, Batya Davidovici
Data on post-transplant Kaposi’s sarcoma in heart and lung transplant recipients are sparse. This study examined the incidence of biopsy-proven post-transplant Kaposi’s sarcoma in thoracic organ recipients over a period of 20 years. As mammalian target of rapamycin inhibitors were introduced in 2006 as optional maintenance immunosuppressive therapy, the overall results were analysed and strati ...
Pages: 1-5
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CLINICAL REPORT
Prognostic Relevance of Pretreatment Peripheral Neutrophil Count and Neutrophil-to-lymphocyte Ratio in Primary Cutaneous Angiosarcoma
Kentaro Awaji, Takuya Miyagawa, Jun Omatsu, Hiroko Numajiri, Toru Kawai, Kaoru Funamizu, Ryosuke Saigusa, Daisuke Yamada, Yoshihide Asano, Shinichi Sato
Systemic inflammatory response markers, including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and monocyte-to-lymphocyte ratio, are useful prognostic factors for various malignant tumours. The aim of this study was to investigate the clinical relevance of these markers in primary cutaneous angiosarcoma. Twenty-six patients were retrospectively divided into 2 groups according to pr ...
Pages: 1-6
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CLINICAL REPORT
Prevalence and Characteristics of Onychomycosis in Patients with Knee Osteoarthritis: A Single-centre Prospective Cross-sectional Study
Soyun Cho, Hanjae Lee, Ji Ye Hwang, Jong Soo Choi, Hyeong Jik Kim, Tae Woo Kim, Seung-Baik Kang
Knee disorders that compromise patients’ lower leg movements and self-care may put these patients at greater risk of onychomycosis. However, little is known about the prevalence of onychomycosis in patients with knee diseases. This study evaluated the prevalence and characteristics of onychomycosis in patients with knee osteoarthritis. A total of 520 consecutive patients with symptomatic knee os ...
Pages: 1-6
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INVESTIGATIVE REPORT
Effects of COVID-19 Lockdown on Tumour Burden of Melanoma and Cutaneous Squamous Cell Carcinoma
Antonio Tejera-Vaquerizo, Sabela Paradela, Agusti Toll, Jorge Santos-Juanes, Ane Jaka, Alba López, Javier Cañueto, Àlvaro Bernal, Isabel Villegas-Romero, Carla Fernández-Pulido, Héctor Perandones, David Moreno-Ramírez, Carolina Domínguez-Mahamud, Rafael Salido-Vallejo, Onofre Sanmartin, Francisco M. Almazán-Fernández, Pedro Rodríguez-Jiménez, José Bañuls, Sebastian Podlipnik, Alejandra Sandoval-Clavijo, Aram Boada, Beatriz García-Bracamonte, Sara Palencia, David Revilla-Nevreda, Enara Reola-Ramírez, María del Carmen Gómez-Mateo, Mario Linares-Barrios, David Jiménez-Gallo, Carlos González-Cruz, Elia Samaniego, María Navedo-de las Heras, Rosa Taberner, Teresa Ródenas-Herranz, Carmen García-Donoso, Susana Puig, Eduardo Nagore
The aim of this study was to compare tumour burden in patients who underwent surgery for melanoma and cutaneous squamous cell carcinoma during nationwide lockdown in Spain due to COVID-19 (for the period 14 March to 13 June 2020) and during the same dates in 2019 before the COVID-19 pandemic. In addition, associations between median tumour burden (Breslow thickness for melanoma and maximum clinica ...
Pages: 1-7
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QUIZ
Semi-circular Depression on the Leg Diagnosed by High-frequency Ultrasound: A Quiz
Eyal Taleb, Ilan Goldberg, Eli Sprecher, Shamir Geller
Abstract is missing (Quiz)
Pages: 1-2
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CLINICAL REPORT
Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: a 28-year Retrospective Study
Susan J. Robertson, Elizabeth Orrin, Manpreet K. Lakhan, Gavin O’Sullivan, Jessie Felton, Alistair Robson, Danielle T. Greenblatt, Catina Bernardis, John A. McGrath, Anna E. Martinez, Jemima E. Mellerio
Epidermolysis bullosa (EB), notably severe recessive dystrophic EB (RDEB-S), is associated with increased risk of aggressive mucocutaneous squamous cell carcinomas, the major cause of mortality in early adulthood. This observational, retrospective case review describes a series of EB patients with cutaneous squamous cell carcinomas over a 28-year period. Forty-four EB patients with squamous cell c ...
Pages: 1-8
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SHORT COMMUNICATION
Complexity of Transcriptional and Translational Interference of Laminin-332 Subunits in Junctional Epidermolysis Bullosa with LAMB3 Mutations
Ping-Chen Hou, Ken Natsuga, Wei-Ting Tu, Hsin-Yu Huang, Brandon Chen, Liang-Yu Chen, Wan-Rung Chen, Yi-Kai Hong, Yen-An Tang, Julia Yu-Yun Lee, Peng-Chieh Chen, H. Sunny Sun, John A. McGrath, Chao-Kai Hsu
Abstract is missing (Short communication)
Pages: 1-3
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SHORT COMMUNICATION
More about Zlotnikov, the Man Who Explained Blaschko’s Lines to be a Mosaic
Rudolf Happle, Eckart Haneke
Abstract is missing (Short communication)
Pages: 1-2
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SHORT COMMUNICATION
Successful Treatment of Acquired Vulvar Lymphangiectasia with 1% Polidocanol Sclerotherapy
Carolyn M. Stull, Uros Rakita, Luke Wallis, Aleksandar Krunic
Abstract is missing (Short Communication)
Pages: 1-2
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QUIZ
Persistent Widespread Pruritic Nodules: A Quiz
Hong-Hao Hu, Wen-Jia Yang, Jiu-Hong Li, Hao Guo
Abstract is missing (Quiz)
Pages: 1-2
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SHORT COMMUNICATION
Effect Modification by Smoking Status on the Association Between Psoriasis and Chronic Obstructive Pulmonary Disease among Adults in the USA
Jeffrey Liu, Amylee Martin, Akshitha Thatiparthi, Jashin J. Wu
Abstract is missing (Short Communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Activation of Transient Receptor Potential Vanilloid-3 Channels in Keratinocytes Induces Pruritus in Humans
Jin Cheol Kim, Han Bi Kim, Won-Sik Shim, In Suk Kwak, Bo Young Chung, Seok Young Kang, Chun Wook Park, Hye One Kim
Carvacrol, a natural transient receptor potential vanilloid-3 activator, has been reported to cause pruritus in mice. This study aimed to evaluate the effects of carvacrol and various antipruritic agents in humans. A stimulation test with carvacrol, β-alanine, and histamine was performed. After application of the pruritic solutions, the skin was stimulated with pinpricks. In inhibition test A, Fo ...
Pages: 1-7
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CLINICAL REPORT
Influence of Port-wine Stains on Quality of Life of Children and Their Parents
Fan Jiang, Junyi Shao, Lele Chen, Nali Yang, Jingjing Liu, Zhiming Li
Port-wine stains are congenital vascular malformations that affect the quality of life of children and their parents. This study used the Family Dermatology Life Quality Index and Children’s Dermatology Life Quality Index to examine the effects of port-wine stains on the quality of life of children and their parents, including an in-depth, systematic analysis of the moderating effects of the chi ...
Pages: 1-5
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INVESTIGATIVE REPORT
Wearing Occlusive Gloves Increases the Density of Staphylococcus aureus in Patients with Hand Eczema
Line Brok Nørreslet, Sofie Marie Edslev, Esben Meulengracht Flachs, Niels Erik Ebbehøj, Paal Skytt Andersen, Tove Agner
Hand eczema is frequently colonized with Staphylococcus aureus. Some patients with hand eczema wear occlusive gloves regularly; however, the effect of this on the density of S. aureus is unexplored. The aim of this study is to examine the effect of occlusive gloves on the density of S. aureus sampled from the hands of patients with hand eczema. In an experimental set-up, patients with moderate-to- ...
Pages: 1-6
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SHORT COMMUNICATION
Serum 5-Hydroxytryptamine is Related to Psoriasis Severity in Patients with Comorbid Anxiety or Depression
Minxue Shen, Duling Cao, Yi Xiao, Yehong Kuang, Danrong Jing, Yajia Li, Panpan Liu, Xiang Chen, Wu Zhu
Abstract is missing (SHort communication)
Pages: 1-2
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