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Investigative Report

Clinical and Histological Effect of a Low Glycaemic Load Diet in Treatment of Acne Vulgaris in Korean Patients: A Randomized, Controlled Trial

doi: 10.2340/00015555-1346

Abstract:

Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin-8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne.

Authors:

Hyuck Hoon Kwon, Ji Young Yoon, Jong Soo Hong, Jae Yoon Jung, Mi Sun Park, Dae Hun Suh

References

  • Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol 2002; 138: 1584–1590.
  • Spencer EH, Ferdowsian HR, Barnard ND. Diet and acne: a review of the evidence. Int J Dermatol 2009; 48: 339–347.
  • Smith RN, Mann NJ, Braue A, Makelainen H, Varigos GA. A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr 2007; 86: 107–115.
  • Cordain L. Implications for the role of diet in acne. Semin Cutan Med Surg 2005; 24: 84–91.
  • Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol 2005; 141: 333–338.
  • Melnik BC, Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol 2009; 18: 833–841.
  • Smith R, Mann N, Makelainen H, Roper J, Braue A, Varigose G. A pilot study to determine the short-term effects of a low glycemic load diet on hormonal markers of acne: a nonrandomized, parallel, controlled feeding trial. Mol Nutr Food Res 2008; 52: 718–726.
  • Brand-Miller JC, Thomas M, Swan V, Ahmad ZI, Petocz P, Colaqiuri S. Physiological validation of the concept of glycemic load in lean young adults. J Nutr 2003; 133: 2728–2732.
  • Rudman SM, Philpott MP, Thomas GA, Kealey T. The role of IGF-I in human skin and its appendages: morphogen as well as mitogen? J Invest Dermatol 1997; 109: 770–777.
  • Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem 2007; 282: 7329–7338.
  • Reynolds R, Lee S, Choi JY, Atkinson F, Stockmann K, Petocz P, et al. Effect of the glycemic index of carbohydrates on acne vulgaris. Nutrients 2010; 2: 1060–1072.
  • Kaymak Y, Adisen E, Ilter N, Bideci A, Gurler D, Celik B. Dietary glycemic index and glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels in patients with acne. J Am Acad Dermatol 2007; 57: 819–823.
  • Foster-Powell K, Holt SH, Brand-Miller JC. International table of glycemic index and glycemic load values. Am J Clin Nutr 2002; 76: 5–56.
  • O’Brien SC, Lewis JB, Cunliffe WJ. The Leeds revised acne grading system. J Dermatol Treat 1998; 9: 215–220.
  • Steiner PE. Necropsies on Okinawans; anatomic and pathologic observations. Arch Pathol (Chic) 1946; 42: 359–380.
  • Deplewski D, Rosenfield RL. Role of hormones in pilosebaceous unit development. Endocr Rev 2000; 21: 363–392.
  • Downie MM, Sanders DA, Kealey T. Modelling the remission of individual acne lesions in vitro. Br J Dermatol 2002; 147: 869–878.
  • Belgorosky A, Baquedano MS, Guercio G, Rivarola MA. Adrenarche: postnatal adrenal zonation and hormonal and metabolic regulation. Horm Res 2008; 70: 257–267.
  • Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet 2007; 370: 685–697.
  • Burton JL, Libman LJ, Cunliffe WJ, Wilkinson R, Hall R, Shuster S. Sebum excretion in acromegaly. BMJ 1972; 1: 406–408.
  • Melnik BC, John SM, Schmitz G. Over-stimulation of insulin/IGF-1 signaling by Western diet may promote diseases of civilization: lessons learnt from Laron syndrome. Nut Metab 2011; 8: 41–45.
  • Tsai MC, Chen W, Cheng YW, Wang CY, Chen GY, Hsu TJ. Higher body mass index is a significant risk factor for acne formation in schoolchildren. Eur J Dermatol 2006; 16: 251–253.
  • Bourne S, Jacobs A. Observations on acne, seborrhoea, and obesity. BMJ 1956; 1: 1268–1270.
  • Melnik BC. Evidence for acne-promoting effects of milk and other insulinotropic dairy products. Nestle Nutr Workshop Ser Pediatr Program 2011; 67: 131–145.
  • Jung JY, Yoon MY, Min SU, Hong JS, Choi YS, Suh DH. The influence of dietary patterns on acne vulgaris in Koreans. Eur J Dermatol 2010; 20: 768–772.
  • Melnik BC. Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies. J Dtsch Dermatol Ges 2009; 7: 364–370.
  • Smith TM, Cong Z, Gilliland KL, Clawson GA, Thiboutout DM. Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol 2006; 126: 1226–1232.
  • Smith TM, Gilliland K, Clawson GA, Thiboutout DM. IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol 2008; 128: 1286–1293.
  • Kallin A, Johannessen LE, Cani PD, Marbehant CY, Essaghir A, Foufelle F, et al. SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. J Lipid Res 2007; 48: 1628–1636.
  • Abd El All HS, Shoukry NS, El Maged RA, Ayada MM. Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris. Diagn Pathol 2007; 2: 4.
  • Livingstone MB, Robson PJ. Measurement of dietary intake in children. Proc Nutr Soc 2000; 59: 279–293.
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    Theme Issue: From Acne to Retinoids and Lymphomas

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    Volume 92, Issue 3

    DOI: 10.2340/00015555-1346

    Pages: 241-246

    View at PubMed