Content - Volume 65, Issue 3

The distribution of fibronectin (FN) was studied in skin biopsies of 13 patients with scleroderma (SD), 7 patients with dermatomyositis (D), and 10 normal controls (NC) by direct immunofluorescence. In normal tissues, continuous or segmental linear staining of the dermal-epidermal junction (DEJ) was seen. Papillary, subpapillary dermis, and papillary capillary loops showed a reticular pattern of d ...

The ability of topical zinc sulfate to augment the cutaneous delayed hypersensitivity response to Candida antigen was evaluated in 47 adults (15 controls and 32 hospitalized patients). On each adult subject, intradermal standard Candida extract was administered to each forearm followed immediately by topical application of 10% zinc sulfate in Aquaphor ointment on one arm and Aquaphor alone on the ...

Macrophages derived from circulating blood monocytes of psoriatic patients demonstrated an enhanced release of beta-glucuronidase and lysozyme compared with macrophages from healthy subjects. The relationship of cell activation to the pathogenesis of psoriasis is discussed.

The influence of experimentally-induced emotional stress on pruritic response of human skin was studied in healthy subjects. Experimental activation of the psychoneuroendocrine system was produced by standardized stressors, i.e. a colour-word-conflict test (Stroop-test) and a subsequent mental arithmetic problem. Pruritus was elicited by intradermal injection of histamine. Results obtained were co ...

A long-term follow-up study (24 years minimum) was made of 955 individuals aged 24-44 years, who had atopic dermatitis (AD) in childhood. The material was divided into two groups; patients who in 1952-56 had been hospitalized on at least one occasion at the Department of Dermatology, Karolinska Hospital, Stockholm (Group 1), and patients who in 1955-56 had been out-patients in the same department ...

During one year 68 patients with pompholyx attending the outpatient clinic at the Department of Dermatology, Lund, were examined with special regard to occupational disability. Owing to pompholyx 56 patients had sick-leave, and in 48 sick-leave lasted more than 1 month. No patient needed change of occupation because of pompholyx, and no disability pension was granted because of the disease.

One hundred and seven psoriatics with palmoplantar involvement were clinically examined. They were selected from 921 patients filed in 1976 with the diagnosis psoriasis. Fifty per cent of the patients with palmoplantar psoriasis had flexural changes. The frequency of palmar involvement in patients with inverse psoriasis compared to patients with psoriasis vulgaris was increased 5.3 times. Pustulos ...

A papular and a diffuse variety of hereditary palmoplantar keratoderma (Unna Thost) are described. It was not possible to demonstrate any histopathological differences between the two varieties. Of the patients examined 36.2% were found to have dermatophytosis in addition to hereditary palmoplantar keratoderma. The hyperkeratosis was smooth and uniform in both varieties. When scaling and fissuring ...

16 patients with clinically and histologically verified necrobiosis lipoidica lesions were treated with either 40 mg acetylsalicylic acid or placebo daily for 24 weeks in a double-blind controlled study. The lesions became statistically significantly larger in both groups in spite of inhibition of the aggregation of the platelets in the acetylsalicylic group.

We investigated the usefulness of the restriction enzyme (RE) fingerprinting for epidemiological tracing in gonococcal disease. The RE patterns of three paired gonococcal isolates showed corresponding identical fingerprints. Within each of the three pairs of epidemiologically linked isolates the respective restriction patterns were completely identical. Also, the restriction patterns of 6 strains ...

Epidermal Langerhans´ cells (LC) were investigated in fresh cryostat sections of ten biopsies from patients with mycologically proven tinea cruris, using OKT6 monoclonal antibodies and avidin-biotin-immunoperoxidase. Compared to the controls, more epidermal LC and an increased number of LC in the upper half of the epidermis were found in the sections from tinea patients. In a double staining meth ...

A patient is presented with cutaneous sarcoidosis of the scalp. Ga-67 was intensively taken up by the skin lesions. Systemic involvement of parotid glands and mediastinum was also demonstrated by Ga-67 scintigraphy. Prednisolone therapy reversed promptly the pathologic Ga-67 uptake. Ga-67 scintigraphy should be performed in all patients suffering from cutaneous sarcoidosis as being the most sensit ...

Sera from 119 patients attending a venereal disease clinic in Copenhagen during May 1983 were screened for antibodies to the newly characterized and isolated retrovirus HTLV-III. Ten out of 45 (22%) homosexual patients and two out of 74 (2.7%) heterosexual patients were found to have antibodies against HTLV-III. The homosexual group (except one case that developed AIDS and died during one year obs ...

A 59-year-old man with palmoplantar keratoderma and rolled spiral hairs on the abdomen and extremities is reported. His father had the same skin manifestations but his brother and sister only keratoderma palmoplantare. Scanning electron microscopy of the rolled hairs showed that they were coiled in a spiral around their own axis. These spiral hairs had lower cysteine than the normal appearing hair ...

A characteristic dermatitis with skin-coloured or erythematous papules localized to the helices and lobes of the ears and to the skin behind the ears was observed in 25 subjects who had been using new, unwashed sheets and pillow-cases containing permanent-pressing resin.

Nasociliary neuralgia has not to our knowledge been linked with inflammatory cutaneous lesions. We observed the phenomenon and postulate that it may be frequent but overlooked.

Platelet aggregation was measured in fasting platelet-rich plasma in 25 psoriatics, 6 of whom were diabetic, 50 normal controls, and 24 diabetics. The aggregating agents employed to induce platelet aggregation included ADP, epinephrine and collagen. Platelet aggregation was significantly increased in psoriatics compared with normal controls. An additive effect was observed when diabetes was associ ...

The prevalence of psoriasis was found to be 0.6% in 2 000 pure Lapps from Kautokeino. Similar low prevalences have been found in Mongolians and Eskimos. HL-A studies have suggested a common origin for these populations.

Recurrent petechiae of the lower legs and signs of asymptomatic primary biliary cirrhosis have been found in three women. Large immune complexes were identified in the serum of three and cryoglobulin/cryofibrinogen in two. Histological examination of skin biopsies revealed a leukocytoclastic vasculitis in all three patients. Direct immunofluorescent studies showed deposits of IgM, C3 and fibrinoge ...

Fourteen patients with monosymptomatic delusions of infestation were followed-up 19-48 months after treatment with pimozide was terminated. Seven patients had remained in remission since the treatment. Three had developed relapses, but were without symptoms with intermittent treatment. Four patients responded poorly to pimozide and had still symptoms at the follow-up. The study indicates, that a l ...

Two cases of periocular micropapular dermatitis with sarcoid-like granulomatous histology are reported. After 8-12 weeks treatment with tetracycline the cutaneous eruptions of both patients cleared. The condition is equivalent to perioral dermatitis.

No abstract available.

No abstract available.