Content - Volume 84, Issue

This article does not have an abstract.

It is known that 28-84% of patients with atopic dermatitis exhibit IgE and/or T-cell reactivity to the opportunistic yeast Malassezia sympodialis ,which can be taken up by immature monocyte-derived dendritic cells(MDDCs), resulting in MDDC maturation. The aim of this study was toinvestigate whether MDDCs from patients with atopic dermatitis responddifferently to M. sympodialis compared to MDDCs ...

Atopicdermatitis is one of the most common chronic diseases of childhood andclosely related to other clinical manifestations of allergy. Theincidence is high and still increasing. The genetic contribution todisease development is substantial and complex. Only recently geneticresearch has begun to focus on this phenotype, and specificsusceptibility genes remain to be found. To identify candidate re ...

Monocytes form a significant component of the inflammatory reaction taking place in the skin of atopic dermatitis and psoriasis. Chemokines are pivotalin mediating the attraction of leucocytes to sites of inflammation. The CC-chemokine, monocyte chemotactic protein 1 (MCP-1/CCL2), is expressed by keratinocytes in both atopic dermatitis and psoriasis. MCP-1 binds to the chemokine receptor CCR2 whic ...

Tostudy the role of mast cell activation in children with atopiceczema/dermatitis syndrome (AEDS), we measured levels of urinary9α,11β-prostaglandin F2 (U-9α,11β-PGF2) by enzyme-linked immunoassay in 88 children (mean age 44 months, range 3-135) with mild (n =32), moderate (n =34) or severe (n =22)AEDS, as well as in 72 non-atopic healthy controls. Fifty-eight of the children with AEDS were se ...

Psoriasisresponds favourably to treatment with retinoids but the cellularpathways mediating these effects are poorly understood. Retinoidsregulate keratinocyte proliferation and maturation via binding tonuclear retinoic acid receptors (mainly RARα and RARγ) which formheterodimers with the 9-cis-RA receptor, RXRα. We have previously shownthat mRNA expression of RARα and RXRα is down-regul ...

Phototherapyof skin diseases such as psoriasis is an effective and safe treatmentmodality. However, increasing the risk of skin cancer by phototherapyis a serious concern. An increased skin cancer risk occurs afterprolonged photochemotherapy (PUVA). In contrast, the role of broadbandUVB or narrowband UVB therapy in skin carcinogenesis of humans withpsoriasis is less clear. Therefore, we investigat ...

Pruritusis a major problem after burn injury; however, prevalence andpredictors of prolonged pruritus are not known. The aims were to assessfrequency of pruritus and the role of personality traits and coping inprolonged pruritus. The participants were burn patients injured 1-18years earlier (n =248). Pruritus was assessed with an item fromthe Abbreviated Burn Specific Health Scale, personality was ...

Circulatingand bound IgA antibodies can be found in the autoimmune blisteringdiseases, but their prevalence, clinical relevance and target antigensremain unknown. Thirty-two patients with pemphigus, 73 with bullouspemphigoid and 28 with mucous membrane pemphigoid were studiedretrospectively. Direct immunofluorescence (DIF) analysis of IgG, IgA,IgM and C3 was carried out for all cases. Sera were st ...

Anetodermais a rare cutaneous disease characterized by a loss of normal elastictissue that is presented clinically as localized areas of wrinkled orflaccid skin. This form may be associated with several immunologicalabnormalities, most notably lupus erythematosus and antiphospholipidantibodies with or without clinical manifestations of theantiphospholipid syndrome. A retrospective study was conduc ...

Wepresent here the course of clinical response of a 53-year-oldhaemodialysed Fabry patient who received recombinant human α-galactosidase A at a dose of 1 mg/kg every other week over a period of 1 year. The therapy was well tolerated by the patient, who revealedan impressive favourable cutaneous, gastrointestinal, neurological andpsychiatric response and a dramatic improvement in his quality of l ...

Contactdermatitis simulating erythema multiforme can be caused by manyallergens. The chemical agent 1,2-ethanedithiol, which serves as aprotective group in chemical synthesis, has hitherto only beenimplicated as an irritant. We report on a 22-year-old female chemistrystudent who developed widespread erythema multiforme-like lesions afterlocal contact with 1,2-ethanedithiol. Many target lesions wer ...

This article does not have an abstract.