Content » Vol 82, Issue 6

Investigative Report

Bcl-2-related Proteins, a-Smooth Muscle Actin and Amyloid Deposits in Aggressive and non-Aggressive Basal Cell Carcinomas

Önder Bozdogan, Emel Erkek, Pinar Atasoy, Mukadder Koçak, Ahu Birol, Muzaffer Çaydere
DOI: 10.1080/000155502762064548


Aberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of ? -smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and ? -smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and ? -smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68 % ), 38 (76 % ) and 41 (82 % ) specimens, respectively. Immunoreactivity for ? -smooth muscle actin was noted both in tumour nests (64 % ) and within the stroma (54 % ). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal ? -smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal ?-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma.


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