Content » Vol 83, Issue 6

Investigative Report

Defective Cyclic Guanosine Monophosphate-gated Calcium Channels and the Pathogenesis of Psoriasis

Roddie C. Mckenzie A1, Yuko Oda A2, Jacek C. Szepietowski A3, Martin J. Behne A2, Theodora Mauro A2
DOI: 10.1080/00015550310014726

Abstract

A positive association between intake of calcium channel blockers and psoriasis has been observed recently. Intake of blockers of voltage-gated calcium ion channels is associated with outbreaks of psoriasis after a latent period in patients with and without a previous family history of psoriasis. This suggests that interfering with calcium influx may trigger psoriasis. Calcium influx also occurs via cyclic guanosine monophosphate-gated channels; human keratinocytes contain functional and non-functional (splice variants) versions of these channels. We show here that keratinocytes and skin from psoriatic individuals express higher levels of mRNA encoding a non-functional cyclic guanosine monophosphate-gated calcium channel and that high expression of the splice variant by transfection of cells in culture leads to loss of protein expression for the functional cyclic guanosine monophosphate-gated Ca2+ channels.

Significance

Supplementary content

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