Failure to Detect Clonality in Eosinophilic Pustular Folliculitis with Follicular Mucinosis
Mi-Woo Lee A1, Deuk-Pyo Lee A1, Jee-Ho Choi A1, Kee-Chan Moon A1, Jai-Kyoung Koh A1
Eosinophilicpustular folliculitis is characterized by an eosinophil-richinflammatory follicular and perifollicular infiltrate primarily centredat the level of the follicular isthmus and sebaceous duct. Follicularmucinosis has been observed in lesions of eosinophilic pustularfolliculitis. Clinical and histological features of eosinophilicpustular folliculitis with follicular mucinosis and alopecia mucinosaare very similar. Alopecia mucinosa may be a clonal T-cell dermatosis.A monoclonal re-arrangement of the T-cell receptor gene was detected inabout half of the cases in alopecia mucinosa. To investigate T-cellclonality in a series of eosinophilic pustular folliculitis withfollicular mucinosis, we performed heteroduplex analysis of re-arranged T-cell receptor γ gene in seven cases of eosinophilic pustularfolliculitis with follicular mucinosis. All cases were negative forheteroduplex-PCR analysis. The failure to demonstrate clonality may beconsistent with a reactive nature of eosinophilic pustular folliculitiswith follicular mucinosis.