Content » Vol 86, Issue 3

Clinical Report

Clonal Spread of Staphylococcus aureus with Reduced Susceptibility to Oxacillin in a Dermatological Hospital Unit

Marianne Kragh Thomsen, Mads Rasmussen, Kurt Fuursted, Henrik Westh, Lisbeth Nørum Pedersen, Mette Deleuran, Jens Kjølseth Møller
DOI: 10.1080/00015555-0072


In November 2000, we became aware of isolates of Staphylo­coccus aureus with borderline resistance to oxacillin (BORSA) from patients in the Department of Dermatology, Aarhus University Hospital. The objective was to describe the isolates phenotypically and genotypically and to assess possible transmission routes in order to intervene and prevent further spread. Clonality of the isolates was confirmed by pulsed field gel electro­phoresis. Several breaches in infection control procedures were revealed suggesting both direct and indirect transmission between patients. Defective skin barriers, high carrier rates of S. aureus in dermatological patients and high consumption rates of dicloxacillin in the department might facilitate transmission. Following improvement of the general infection control measures, and after reassessment of the antibiotic policy in the department, the outbreak has disappeared.


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