Content » Vol 87, Issue 5

Clinical Report

Early Disseminated Borreliosis with Multiple Erythema Migrans and Elevated Liver Enzymes: Case Report and Literature Review

Frauke Benedix, Benjamin Weide, Sigrid Broekaert, Gisela Metzler, Julia-Stefanie Frick, Walter H.C. Burgdorf, Martin Röcken, Martin Schaller
DOI: 10.2340/00015555-0267


A 69-year-old man presented with multiple livid maculae and infiltrated urticarial plaques, as well as elevated liver enzymes. Based on typical clinical picture, histopatho­logy and positive PCR from a skin biopsy, we diagnosed an early disseminated infection with Borrelia afzelii presenting with multiple erythema migrans (erythemata migrantia) and a subclinical hepatitis. During antibiotic treatment with intravenous ceftriaxone, the maculae and plaques vanished almost completely and the liver enzymes decreased within 14 days. Dermatologists should keep in mind that early disseminated borreliosis can present with multiple erythema migrans and hepatitis.


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