Content » Vol 90, Issue 1

Clinical Report

Lichenoid Drug Eruption with Palmoplantar Hyperkeratosis due to Imatinib Mesylate: A Case Report and a Review of the Literature

Natsuki Kuraishi, Yayoi Nagai, Michiko Hasegawa, Osamu Ishikawa
DOI: 10.2340/00015555-0758


Cutaneous adverse effects of imatinib mesylate (Glivec®) are common and various types of skin eruptions have been reported. We report here a 57-year-old man who presented with lichen planus-like lesions on his extremities and palmoplantar hyperkeratosis due to the use of imatinib mesylate for chronic myeloid leukaemia. The skin lesions improved after discontinuation of imatinib mesylate but re-administration of the drug at a lower dose provoked a mild recurrence. He could, however, continue to take the drug at the lower dose and his skin lesions were well-controlled by topical corticosteroid treat­ment. The literature on lichenoid drug eruption due to imatinib mesylate is reviewed.


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