Content » Vol 90, Issue 6

Investigative Report

Treatment with a Barrier-strengthening Moisturizer Prevents Relapse of Hand-eczema. An Open, Randomized, Prospective, Parallel Group Study

Marie Lodén, Karin Wirén, Knut Smerud, Nils Meland, Helge Hønnås, Gro Mørk, Claus Lützow-Holm, Jörgen Funk, Birgitta Meding
DOI: 10.2340/00015555-0964


Hand eczema influences the quality of life. Management strategies include the use of moisturizers. In the present study the time to relapse of eczema during treatment with a barrier-strengthening moisturizer (5% urea) was compared with no treatment (no medical or non-medicated preparations) in 53 randomized patients with successfully treated hand eczema. The median time to relapse was 20 days in the moisturizer group compared with 2 days in the no treatment group (p = 0.04). Eczema relapsed in 90% of the patients within 26 weeks. No difference in severity was noted between the groups at relapse. Dermatology Life Quality Index (DLQI) increased significantly in both groups; from 4.7 to 7.1 in the moisturizer group and from 4.1 to 7.8 in the no treatment group (p < 0.01) at the time of relapse. Hence, the application of moistur­izers seems to prolong the disease-free interval in patients with controlled hand eczema. Whether the data is applic­able to moisturizers without barrier-strengthening properties remains to be elucidated.


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