Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype
Greta Gourier, Chloé Théréné, Margaux Mazeas, Claire Abasq-Thomas, Emilie Brenaut, Flavien Huet, Haitham Sonbol, Elize Campillo, Julie Lemerle, Elisabeth Pasquier, Emmanuelle Le Moigne, Alain Saraux, Valérie Devauchelle-Pensec, Laurent Misery, Yves Renaudineau
Pruritus is a frequent symptom in systemic sclerosis (SSc), with a prevalence of 40–65%, but its pathophysiology is poorly understood. This study investigated the immunological component of pruritus. Fifty-six patients with SSc responded to a standardized questionnaire regarding both SSc disease and pruritus characteristics. Among patients with SSc, those with pruritus did not display a particular immunological profile (inflammatory, humoral, and/or cellular factors), but pruritus was, in most cases, concomitant with the development of SSc. Thus, pruritus characteristics were evaluated further, according to the detection of anti-centromere autoantibodies (ACA), into ACA+ (n = 17) and ACA– (n = 19). The ACA+ subgroup was characterized by a longer evolution of SSc and pruritus, pruritus present outside the sclerotic area, and a shorter daily duration of pruritus. In conclusion, the concomitant appearance of the 2 processes and the differences observed between ACA+ and ACA– subgroups support the presence of an immunological component in pruritus.