Eran Galili, Aviv Barzilai, Gilad Twig, Tomm Caspi, Danny Daniely, Rony Shreberk-Hassidim, Nadav Astman
DOI: 10.2340/00015555-3485

Few studies have reported an association between psoriasis and atopic comorbidity in adults. A population-based cross-sectional study was performed to investigate the possible association of psoriasis with allergic rhinitis or asthma among adolescents. Adolescents (16–18 years of age) medically evaluated for military service between 1999 and 2014 were included. Medical records were obtained from the database of the Israeli Defense Forces. Of the 887,765 adolescents studied, 3,112 patients had psoriasis (56.1% mild; 43.9% moderate-to-severe). Psoriasis was significantly associated with allergic rhinitis (adjusted odds ratio (aOR) 1.3; 95% confidence interval (CI) 1.2–1.5) and asthma (aOR 1.2; 95% CI 1.0–1.3), compared with controls without psoriasis. Moderate-to-severe psoriasis was associated with allergic rhinitis (aOR 1.3; 95% CI 1.1–1.5) and asthma (aOR 1.5; 95% CI 1.2–1.7), while mild psoriasis was only associated with allergic rhinitis (aOR 1.4; 95% CI 1.2–1.6). In conclusion, amongst adolescents, psoriasis was found to be associated with allergic rhinitis and asthma.

In a population-based cross-sectional study among adolescents, psoriasis was shown to be significantly associated with allergic rhinitis and asthma. The association between psoriasis and asthma was found only in moderate-to-severe psoriasis, while the association with allergic rhinitis was not dependent on psoriasis severity.